Ziel/Aim
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) plays an important role
in the staging and response assessment of lymphoma patients. Our aim was to explore
the prognostic relevance of metabolic tumor volume (MTV) and total lesion glycolysis
(TLG) in patients with early stage Hodgkin lymphoma treated within the German Hodgkin
Study Group HD16 trial.
Methodik/Methods
18F-FDG PET/CT images were available for MTV and TLG analysis in 107 patients from the
HD16 trial. We calculated MTV and TLG each using three different threshold methods
and performed receiver-operating-characteristic analysis to describe the prognostic
impact for an adequate therapy response with PET negativity after 2 cycles of chemotherapy.
Ergebnisse/Results All the methods analyzed for MTV and TLG calculation showed a certain correlation
with the PET response after 2 cycles chemotherapy. The largest area under the curve
(AUC) showed the fixed threshold of SUV4.0 for MTV (AUC 0.69 [95% CI 0.55–0.83]) and for TLG(AUC 0.69 [0.55–0.82]). Other thresholds
considered were SUV140 (AUC for MTV 0.66 [0.53–0.80], AUC for TLG 0.67 [0.54–0.81]) and SUV41% (AUC for MTV 0.61 [0.45–0.76], AUC for TLG 0.64 [0.49–0.80]). ROC curves do not suggest
any specific cutoffs. Overall, TLG was not superior to MTV in its predictive capacity.
Schlussfolgerungen/Conclusions MTV and TLG show a moderate effect on outcome after two cycles ABVD in early stage
Hodgkin lymphoma, particularly when using the fixed threshold of SUV4.0
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