Nuklearmedizin 2022; 61(02): 150
DOI: 10.1055/s-0042-1745977
Abstracts | NuklearMedizin 2022
Leuchtturm
PET Onkologie

Diagnostic performance of [124I]m-iodobenzylguanidine PET/CT in patients with pheochromocytoma

M. Weber
1   Essen
,
J. Schmitz
2   Universitätsklinikum Essen, Nuklearmedizin, Essen
,
I. Maric
2   Universitätsklinikum Essen, Nuklearmedizin, Essen
,
K. Pabt
2   Universitätsklinikum Essen, Nuklearmedizin, Essen
,
L. Umutlu
3   Universitätsklinikum Essen, Radiologie, Essen
,
M. Walz
4   Kliniken Essen-Mitte, Viszeralchirurgie, Essen
,
K. Herrmann
2   Universitätsklinikum Essen, Nuklearmedizin, Essen
,
C. Rischpler
2   Universitätsklinikum Essen, Nuklearmedizin, Essen
,
F. Weber
5   Kliniken Essen-Mitte, Radiologie, Essen
,
W. Jentzen
2   Universitätsklinikum Essen, Nuklearmedizin, Essen
,
S. Theurer
6   Universitätsklinikum Essen, Pathologie, Essen
,
T. Poeppel
7   MVZ CDT Strahleninstitut, Nuklearmedizin, Köln
,
N. Unger
8   Universitätsklinikum Essen, Endokrinologie, Essen
,
W.P. Fendler
9   Kliniken Essen-Mitte, Nuklearmedizin, Essen
› Author Affiliations
 
 

    Ziel/Aim 123/131I-MIBG scintigraphy has shown a high specificity for imaging pheochromocytoma and paraganglioma however with low sensitivity due to low spatial resolution. 124I-MIBG PET may overcome this limitation to improve the staging of patients with (suspected) pheochromocytoma.

    Methodik/Methods We analyzed the sensitivity, specificity, positive and negative predictive values (PPV, NPV) of 124I-MIBG PET in 43 consecutive patients with suspected (recurrence of) pheochromocytoma using histopathological (n=25) and clinical validation (n=18) as standard of truth. Furthermore, we compared 124I-MIBG PET versus contrast enhanced CT (CE-CT) per-patient and per-lesion detection rate of 124I-MIBG PET in 13 additional patients with known metastatic malignant pheochromocytoma (MMP).

    Ergebnisse/Results 124I-MIBG PET/CT was positive in 19/43 (44%) patients with suspected pheochromocytoma. Presence of pheochromocytoma was confirmed in 22/43 (51%). 124I-MIBG PET/CT sensitivity, specificity, PPV, NPV were 86%, 100%, 100%, 88%, respectively. 124I-MIBG PET was positive in 11/13 (85%) MMP patients. Combined 124I-MIBG PET and CE-CT detected 173 lesions, of which 166 (96%) and 118 (68%) were visible on 124I-MIBG PET and CE-CT, respectively.

    Schlussfolgerungen/Conclusions 124I-MIBG PET detects pheochromocytoma with high accuracy at initial staging and high detection rate at re-staging. Future assessment of 124I-MIBG PET for treatment guidance including personalized 131I-MIBG therapy is warranted.


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    Publication History

    Article published online:
    14 April 2022

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