Endoscopy 2022; 54(S 01): S16-S17
DOI: 10.1055/s-0042-1744590
Abstracts | ESGE Days 2022
ESGE Days 2022 Oral presentations
1:00–12:00 Thursday, 28 April 2022 Club E. Endoscopic grading and surveillance in IBD

DYE ANOTHER DAY: DYE-BASED CHROMOENDOSCOPY VERSUS I-SCAN VIRTUAL CHROMOENDOSCOPY IN LONG-STANDING UC: A MULTICENTER PROSPECTIVE RANDOMIZED CONTROLLED TRIAL

Authors

  • P. Sinonquel

    1   UZ Leuven, Gastroenterology and Hepatology, Leuven, Belgium
    2   KU Leuven, Translational Research in Gastrointestinal Diseases, Leuven, Belgium

  • A. Jans

    3   UZ Leuven, Internal Medicine, Leuven, Belgium

  • M. Pierick

    4   MUMC, Gastroenterology, Maastricht, Netherlands

  • T. Seerden

    5   Amphia Hospital, Gastroenterology, Breda, Netherlands

  • S. Sloth

    6   Copenhagen University Hospital, GastroUnit, Herlev, Denmark

  • J.G. Karstensen

    6   Copenhagen University Hospital, GastroUnit, Herlev, Denmark
    7   Copenhagen University Hospital, GastroUnit, Amager, Denmark

  • G. De Hertogh

    8   UZ Leuven, Pathology, Leuven, Belgium

  • I. Demedts

    1   UZ Leuven, Gastroenterology and Hepatology, Leuven, Belgium

  • H. Willekens

    9   UZ Leuven, Endoscopy, Leuven, Belgium

  • S. Vermeire

    1   UZ Leuven, Gastroenterology and Hepatology, Leuven, Belgium
    2   KU Leuven, Translational Research in Gastrointestinal Diseases, Leuven, Belgium

  • R. Bisschops

    1   UZ Leuven, Gastroenterology and Hepatology, Leuven, Belgium
    2   KU Leuven, Translational Research in Gastrointestinal Diseases, Leuven, Belgium
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Aims Long-standing ulcerative colitis (UC) has an increased risk for developing colorectal dysplasia and neoplasia. Dye-based chromoendoscopy (DCE) and virtual chromoendoscopy (VCE) increase detection of neoplastic lesions. However, limited data are available on the impact of i-scan VCE for UC neoplasia detection. We undertook a prospective randomized controlled trial to compare the neoplasia detection between DCE and i-scan in patients with long-standing UC.

Methods In 4 European hospitals, 136 patients with long-standing UC (mean disease duration 19.88 (DCE) vs 18.49 years (i-scan)) were randomized (1:1) to either DCE with methylene blue 0.1% (n=71) or i-scan (n=65). Biopsies were taken from visible lesions and surrounding mucosa. Neoplasic lesions included any type of dysplasia, polyp or carcinoma. Statistical analysis was performed using t-test for continuous data and Fishers’ exact for proportions.

Results The neoplasia detection rate was not significantly different between the DCE (18.3%) vs VCE (26.2%) group, respectively (OR 0.63, 95%CI 0.27 – 1.37, p=0.305). However, the per lesion neoplasia detection was significantly better with i-scan than with DCE (14.5% vs 33.9%, p=0.033). The mean number of neoplastic lesions per colonoscopy was 0.24 for DCE and 0.32 for i-scan (p=0.432). Both withdrawal and total procedural time were on average 10.1 and 9.8 minutes shorter in the i-scan group (p<0.001).

Conclusions This multicenter prospective randomized trial showed that in long-standing UC patients, no significant difference in neoplasia detection was found between DCE and i-scan. However, i-scan had a lower false positive rate and a significant shorter procedure time. I-scan could therefore be a valid replacement for DCE.


Publication History

Article published online:
14 April 2022

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