Virale Atemwegserkrankungen – neue Viren

Viren sind verantwortlich für die allermeisten respiratorischen Infektionen weltweit. Hochsensitive und hochspezifische Nachweisverfahren sind nötig – ebenso wie eine gezielte Therapie. Wie sich welches Virus nachweisen lässt und wie weit die Entwicklung geeigneter Therapeutika und Impfstoffe fortgeschritten ist, lesen Sie in diesem Beitrag.

• Literatur

• 1 Patarcic I, Gelemanovic A, Kirin M. et al. The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis. Sci Rep 2015;
• 2 Lee KH, Gordon A, Foxman B. The role of respiratory viruses in the etiology of bacterial pneumonia. Evol Med Public Health 2016; 2016: 95-109
• 3 McKay KA, Jahanfar S, Duggan T. et al. Factors associated with onset, relapses or progression in multiple sclerosis: A systematic review. Neurotoxicology 2016;
• 4 Mahony JB, Petrich A, Smieja M. Molecular diagnosis of respiratory virus infections. Crit Rev Clin Lab Sci 2011; 48: 217-249
• 5 Sommerville LK, Ratnamohan VM, Dwyer DE. et al. Molecular diagnosis of respiratory viruses. Pathology 2015; 47: 243-249
• 6 Higgins D, Trujillo C, Keech C. Advances in RSV vaccine research and development – A global agenda. Vaccine 2016;
• 7 Mejias A, Ramilo O. New options in the treatment of respiratory syncytial virus disease. J Infect 2015; 71 : S80-S87
• 8 Acha PN, Szyfres B. Zoonoses and Communicable Diseases Common to Man and Animals. 3. Aufl. Washington DC: Pan American Health Organization; 2003
• 9 Tong S, Zhu X, Li Y. et al. New World Bats Harbor Diverse Influenza A Viruses. PLoS Pathogens 2013; 9: e1003657
• 10 Ott S, Lepper P, Hauptmeier B. et al. Die Rolle von Viren bei tiefen Atemwegsinfektionen des Erwachsenen – Teil 1: Erreger, Pathogenese und Diagnostik. Pneumologie 2009; 63: 709-717
• 11 Esposito S, Montinaro V, Groppali E. et al. N. Live attenuated intranasal influenza vaccine. Hum Vaccin Immunother 2012; 8: 115-119
• 12 Smucny J, Fahey T, Becker L. et al. Antibiotics for acute bronchitis. Cochrane Database Syst Rev 2004; 18: CD000245
• 13 Hurt AC, Hui DS, Hay A. et al. Overview of the 3rd isirv-Antiviral Group Conference – advances in clinical management. Influenza Other Respir Viruses 2015; 9: 20-31
• 14 Nakai A, Saito S, Unno N. et al. Review of the pandemic (H1N1) 2009 among pregnant Japanese women. J Obstet Gynaecol Res 2012; 38: 757-762
• 15 Hui DS, Zumla A. Emerging respiratory tract viral infections. Curr Opin Pulm Med 2015; 21: 284-292
• 16 Smee DF, Tarbet EB, Furuta Y. et al. Synergistic combinations of favipiravir and oseltamivir against wild-type pandemic and oseltamivir-resistant influenza A virus infections in mice. Future Virol 2013; 8: 1085-1094
• 17 Blank PR, Schwenkglenks M, Szucs TD. Influenza vaccination coverage rates in five European countries during season 2006/07 and trends over six consecutive seasons. BMC Public health 2008; 8: 272
• 18 Wen SC, William JV. New Approaches for Immunization and Therapy against Human Metapneumovirus. Clin Vaccine Immunol 2015; 22: 858-866
• 19 Schuster JE, Williams JV. Human Metapneumovirus. Microbiol Spectr 2014; DOI: 10.1128/microbiolspec.AID-0020-2014
• 20 Williams JV, Wang CK, Yang CF. et al. The role of human metapneumovirus in upper respiratory tract infections in children: a 20-year experience. J Infect Dis 2006; 193: 387-395
• 21 Kitanovski L, Kopriva S, Pokorn M. et al. Treatment of severe human metapneumovirus (hMPV) pneumonia in an immunocompromised child with oral ribavirin and IVIG. J Pediatr Hematol Oncol 2013; 35: e311-e313
• 22 Báez-Santos YM, Mielech AM, Deng X. et al. Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus. J Virol 2014; 88: 12511-12527
• 23 Milne-Price S, Miazgowicz KL, Munster VJ. The emergence of the Middle East respiratory syndrome coronavirus. Pathog Dis 2014; 71: 121-136
• 24 Prasannavenkatesh D, Batool M, Shah M. et al. Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control. Exp Mol Med 2015; 47: e181
• 25 Fehr AR, Perlman S. Coronaviruses: An Overview of Their Replication and Pathogenesis. Methods Mol Biol 2015; 1282: 1-23
• 26 Zhang N, Jiang S, Du L. Current advancements and potential strategies in the development of MERS-CoV vaccines. Expert Rev Vaccines 2014; 13: 761-774
• 27 Broccolo F, Falcone V, Esposito S. Human bocaviruses: Possible etiologic role in respiratory infection. J Clin Virol 2015; 72: 75-81
• 28 Daleno C, Greenberg D, Piralla A. A novel human enterovirus C (EV-C118) identified in two children hospitalised because of acute otitis media and community-acquired pneumonia in Israel. J Clin Virol 2013; 56: 159-162
• 29 Greninger AL, Naccache SN, Messacar K. A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012–14): a retrospective cohort study. Lancet Infect Dis 2015; 15: 671-682
• 30 Royston L, Tapparel C. Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC. Viruses 2016; 8: e16