Abstract
Patients and methods A comprehensive literature search was conducted. We measured pooled rate of lesion
visualization improvement and improvement in lesion detection comparing FICE settings
1 – 3 and WLE, for angioectasias and ulcers/erosions. Pooled results were derived
using the random-effects model because of high heterogeneity as measured by I
2. Repeated-measures analysis of variance (ANOVA) was used to measure differences in
lesion detection between WLE and the three FICE modes.
Results 13 studies were analyzed. All studies used the PillCam SB 1 and/or SB 2 devices.
Most used experienced readers. Improvement in delineation had been investigated in
4 studies; in the 3 studies entered into the meta-analysis, using FICE setting 1,
89 % of angioectasias and 45 % of ulcer/erosions were considered to show improved
delineation. For FICE settings 2 and 3, small proportions of images showed improved
delineation. Heterogeneity of studies was high with I
2 > 90 % in 4/6 analyses. Lesion detection had been investigated in 10 studies; meta-analysis
included 5 studies. Lesion detection did not differ significantly between any of the
FICE modes and WLE.
Conclusions Overall, the use of the three FICE modes did not significantly improve delineation
or detection rate in SBCE. In pigmented lesions, FICE setting 1 performed better in
lesion delineation and detection.
