Horm Metab Res 2016; 48(12): 862-864
DOI: 10.1055/s-0042-120846
Letter to the Editor
© Georg Thieme Verlag KG Stuttgart · New York

Measurement of TSH Receptor Epitope-Specific T Cells in Graves’ Disease

S. Allelein
1   Division for Specific Endocrinology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany
,
A. Kuebart
1   Division for Specific Endocrinology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany
,
M. Haase
1   Division for Specific Endocrinology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany
,
T. Dringenberg
1   Division for Specific Endocrinology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany
,
C. Schmid
1   Division for Specific Endocrinology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany
,
M. Schott
1   Division for Specific Endocrinology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany
,
M. Ehlers
1   Division for Specific Endocrinology, Medical Faculty, University of Duesseldorf, Duesseldorf, Germany
› Author Affiliations
Further Information

Publication History

received 04 November 2016

accepted 08 November 2016

Publication Date:
06 December 2016 (online)

 
  • References

  • 1 Morshed SA, Latif R, Davies TF. Delineating the autoimmune mechanisms in Graves’ disease. Immunol Res 2012; 54: 191-203
  • 2 Ajjan RA, Weetman AP. The Pathogenesis of Hashimoto’s Thyroiditis: Further Developments in our Understanding. Horm Metab Res 2015; 47: 702-710
  • 3 Bahn RS. Current Insights into the Pathogenesis of Graves’ Ophthalmopathy. Horm Metab Res 2015; 47: 773-778
  • 4 Duntas LH. The Role of Iodine and Selenium in Autoimmune Thyroiditis. Horm Metab Res 2015; 47: 721-726
  • 5 Kong YM, Brown NK, Morris GP, Flynn JC. The Essential Role of Circulating Thyroglobulin in Maintaining Dominance of Natural Regulatory T Cell Function to Prevent Autoimmune Thyroiditis. Horm Metab Res 2015; 47: 711-720
  • 6 Morshed SA, Davies TF. Graves’ Disease Mechanisms: The Role of Stimulating, Blocking, and Cleavage Region TSH Receptor Antibodies. Horm Metab Res 2015; 47: 727-734
  • 7 Pujol-Borrell R, Gimenez-Barcons M, Marin-Sanchez A, Colobran R. Genetics of Graves’ Disease: Special Focus on the Role of TSHR Gene. Horm Metab Res 2015; 47: 753-766
  • 8 Rostamzadeh D, Dabbaghmanesh MH, Shabani M, Hosseini A, Amirghofran Z. Expression Profile of Human Fc Receptor-Like 1, 2, and 4 Molecules in Peripheral Blood Mononuclear Cells of Patients with Hashimoto’s Thyroiditis and Graves’ Disease. Horm Metab Res 2015; 47: 693-698
  • 9 Ruffilli I, Ferrari SM, Colaci M, Ferri C, Fallahi P, Antonelli A. IP-10 in autoimmune thyroiditis. Horm Metab Res 2014; 46: 597-602
  • 10 Wimmer I, Hartmann T, Brustbauer R, Minear G, Dam K. Selenium levels in patients with autoimmune thyroiditis and controls in lower Austria. Horm Metab Res 2014; 46: 707-709
  • 11 Wang L, Wang B, Chen SR, Hou X, Wang XF, Zhao SH, Song JQ, Wang YG. Effect of Selenium Supplementation on Recurrent Hyperthyroidism Caused by Graves’ Disease: A Prospective Pilot Study. Horm Metab Res 2016; 48: 559-564
  • 12 Dalan R, Leow MK. Immune manipulation for Graves’ disease: re-exploring an unfulfilled promise with modern translational research. Eur J Intern Med 2012; 23: 682-691
  • 13 Weetman AP. Graves’ disease. N Engl J Med 2000; 343: 1236-1248
  • 14 Latrofa F, Chazenbalk GD, Pichurin P, Chen CR, McLachlan SM, Rapoport B. Affinity-enrichment of thyrotropin receptor autoantibodies from Graves’ patients and normal individuals provides insight into their properties and possible origin from natural antibodies. J Clin Endocrinol Metab 2004; 89: 4734-4745
  • 15 Rapoport B, McLachlan SM. Graves’ hyperthyroidism is antibody-mediated but is predominantly a Th1-type cytokine disease. J Clin Endocrinol Metab 2014; 99: 4060-4061
  • 16 Weetman AP, Yateman ME, Ealey PA, Black CM, Reimer CB, Williams Jr. RC, Shine B, Marshall NJ. Thyroid-stimulating antibody activity between different immunoglobulin G subclasses. J Clin Invest 1990; 86: 723-727
  • 17 Ehlers M, Thiel A, Bernecker C, Porwol D, Papewalis C, Willenberg HS, Schinner S, Hautzel H, Scherbaum WA, Schott M. Evidence of a combined cytotoxic thyroglobulin and thyroperoxidase epitope-specific cellular immunity in Hashimoto’s thyroiditis. J Clin Endocrinol Metab 2012; 97: 1347-1354
  • 18 Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet 2014; 383: 69-82
  • 19 Libert F, Lefort A, Gerard C, Parmentier M, Perret J, Ludgate M, Dumont JE, Vassart G. Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. Biochem Biophys Res Commun 1989; 165: 1250-1255
  • 20 Nagayama Y, Kaufman KD, Seto P, Rapoport B. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Commun 1989; 165: 1184-1190
  • 21 Inaba H, Martin W, De Groot AS, Qin S, De Groot LJ. Thyrotropin receptor epitopes and their relation to histocompatibility leukocyte antigen-DR molecules in Graves’ disease. J Clin Endocrinol Metab 2006; 91: 2286-2294
  • 22 Martin A, Nakashima M, Zhou A, Aronson D, Werner AJ, Davies TF. Detection of major T cell epitopes on human thyroid stimulating hormone receptor by overriding immune heterogeneity in patients with Graves’ disease. J Clin Endocrinol Metab 1997; 82: 3361-3366
  • 23 Soliman M, Kaplan E, Yanagawa T, Hidaka Y, Fisfalen ME, DeGroot LJ. T-cells recognize multiple epitopes in the human thyrotropin receptor extracellular domain. J Clin Endocrinol Metab 1995; 80: 905-914
  • 24 Hunt N, Willey KP, Abend N, Northemann W, Leidenberger FA. Epitope mapping of a recombinant human TSH receptor extracellular domain: identification of a predominant epitope using animal sera. J Clin Lab Anal 1996; 10: 193-204