MR Spectroscopy Findings in Retired Professional Rugby League Players

Andrew J. Gardner; Grant L. Iverson; Magdalena Wojtowicz; Christopher R. Levi; Frances Kay-Lambkin; Peter W. Schofield; Ross Zafonte; Sandy R. Shultz; Alexander P. Lin; Peter Stanwell

doi:10.1055/s-0042-120843

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2017; 38(03): 241-252
DOI: 10.1055/s-0042-120843

Clinical Sciences

MR Spectroscopy Findings in Retired Professional Rugby League Players

Authors

Andrew J. Gardner

¹Centre for Translational Neuroscience & Mental Health, School of Medicine & Public Health, University of Newcastle, Waratah, Australia
Grant L. Iverson

²Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, United States
Magdalena Wojtowicz

²Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, United States
Christopher R. Levi

³Sports Concussion Program, Hunter New England Local Health District, New Lambton Heights, Australia
Frances Kay-Lambkin

⁴National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia
Peter W. Schofield

⁵Neuropsychiatry Service, Hunter New England Local Health District, New Lambton, Australia
Ross Zafonte

²Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, United States
Sandy R. Shultz

⁶Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Melbourne, Australia
Alexander P. Lin

⁷Department of Radiology, Center for Clinical Spectroscopy, Brigham & Women’s Hospital, Harvard Medical School, Boston, United States
Peter Stanwell

⁸School of Health Sciences, University of Newcastle, Callaghan, Australia

Abstract

The aim of this study was to examine brain neurometabolite concentrations in retired rugby league players who had a history of numerous self-reported concussions. Participants were 16 retired professional rugby league players (ages 30–45 years) with an extensive history of concussion and participation in contact sports, and 16 age- and education-matched controls who had no history of neurotrauma or participation in contact sports. All completed a clinical interview, psychological and cognitive testing, and magnetic resonance spectroscopy (MRS) investigation. MRS voxels were placed in posterior cingulate grey matter and parietal white matter. Neurometabolite concentrations were quantified using LCModel. It was hypothesized that retired athletes would differ on N-acetyl aspartate, myo-inositol, choline, glutamate, and glutathione. Retired players had significantly lower concentrations of grey matter glutathione (p=0.02, d=0.91). They did not significantly differ in concentrations of other neurometabolites. There were no significant differences between groups on measures of depression, anxiety, or cognitive functioning. The retired athletes reported significantly greater alcohol use (p<0.01; Cohen’s d=1.49), and they had worse manual dexterity using their non-dominant hand (p=0.03; d=1.08). These preliminary findings suggest that MRS might be modestly sensitive to biochemical differences in athletes after their athletic careers have ended in the absence of clinical differences in cognitive performance and self-reported psychological functioning.

Key words

concussion - neuroimaging - retired athletes - spectroscopy

Full Text

References

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