Abstract
Pyridazines, their oxo derivatives; pyridazinone as well as fused bi- or tricyclic
pyridazine containing scaffolds are key structural features of many biologically active
compounds with diverse pharmacological applications, including cancer therapy. Since
protein kinases play prominent role in tumor biology, the inhibition of its signaling
pathway is considered an effective therapeutic option for the treatment of cancer.
Based on the various advantages of pyridazines in drug design including modulation
of the physico-chemical properties, improving ADME and toxicity profile as well as
easy and diverse synthetic methods of access, makes them an invaluable tool for designing
compounds as future drugs for targeted cancer treatment.
In this review, we have compiled and discussed the anticancer potential of pyridazine
based scaffold, with special focus on those targeting protein kinase inhibition.
Key words
pyridazines - anti-cancer - kinases - anti-proliferative