Frauenheilkunde up2date 2016; 10(04): 311-330
DOI: 10.1055/s-0042-112440
Allgemeine Gynäkologie und gynäkologische Onkologie
Georg Thieme Verlag KG Stuttgart · New York

Die operative Therapie der Endometriose

Stefan P. Renner
,
Johannes Lermann
,
Stefanie Burghaus
,
Christine Fahlbusch
,
Katharina Heusinger
,
Simon Blum
,
Tobias Brodkorb
,
Thomas Hildebrandt
,
Matthias W. Beckmann
,
Janina Hackl
Further Information

Publication History

Publication Date:
19 August 2016 (online)

Kernaussagen

Zur Behandlung der Endometriose stehen verschiedene Maßnahmen zur Verfügung wie die endokrine, die analgetische und die operative Therapie einzeln oder in Kombination. Die individuelle Situation der Patientin gilt es immer zu berücksichtigen. Vor Planung einer operativen Sanierung steht eine umfassende Diagnostik, um eine mögliche Untertherapie oder Übertherapie der zu Rezidiven neigenden Erkrankung zu vermeiden und um das Ausmaß der Endometriose vor den häufig komplexen Eingriffen zu erfassen und diese suffizient zu planen.

Bei Verdacht auf Endometriose sollte zur Diagnosesicherung die diagnostische Laparoskopie durchgeführt werden (Goldstandard) und im Falle nachweisbarer Endometriose zur sanierenden Operation erweitert werden. Ziel ist die Resektion in sano, die auch in fortgeschrittenen Stadien und bei tief infiltrierender Endometriose unter Einbeziehung anderer Fachrichtungen (Urologie, Chirurgie) sehr häufig laparoskopisch möglich ist. Für die unterschiedlich eingesetzten Techniken bei tief infiltrierender Endometriose liegen keine belastbaren Evidenzen vor. Neben der Operation spielt die medikamentöse Therapie eine nicht minder wichtige Rolle zur Vermeidung von Rezidiven und zur Symptomkontrolle.

 
  • Literatur

  • 1 Knapp VJ. How old is endometriosis? Late 17th and 18th century European descriptions of the disease. Fertil Steril 1999; 72: 10-14
  • 2 Mahmood TA, Templeton A. Prevalence and genesis of endometriosis. Hum Reprod 1991; 6: 544-549
  • 3 Moen MH, Schei B. Epidemiology of endometriosis in a Norwegian county. Acta Obstet Gynecol Scand 1997; 76: 559-562
  • 4 Viganò P, Parazzini F, Somigliana E et al. Endometriosis: epidemiology and aetiological factors. Best Pract Res Clin Obstet Gynaecol 2004; 18: 177-200
  • 5 Witz CA, Burns WN. Endometriosis and infertility: is there a cause and effect relationship?. Gynecol Obstet Invest 2002; 53 (Suppl. 01) 2-11
  • 6 Sampson J. Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obst Gynecol 1927; 14: 442-469
  • 7 Meyer R. Über den Stand der Frage der Adenomyositis, Adenomyome im Allgemeinen und insbesondere über Adenomyositis seroepithelialis und Adenomyometritis sarcomatosa. Zentralbl Gynakol 1919; 36: 745-750
  • 8 Schindler A. Epidemiologie, Pathogenese und Diagnostik der Endometriose. J Fertil Reprod 2007; 17: 22-27
  • 9 Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 1997; 67: 817-821
  • 10 Tuttlies F, Keckstein J, Ulrich U et al. [ENZIAN-score, a classification of deep infiltrating endometriosis]. Zentralbl Gynakol 2005; 127: 275-281
  • 11 Stiftung Endometriose-Forschung SEF. SEF-Sitzung „Weissensee Treffen 2012“.
  • 12 Haas D, Chvatal R, Habelsberger A et al. Comparison of revised American Fertility Society and ENZIAN staging: a critical evaluation of classifications of endometriosis on the basis of our patient population. Fertil Steril 2011; 95: 1574-1578
  • 13 Pritts EA, Taylor RN. An evidence-based evaluation of endometriosis-associated infertility. Endocrinol Metab Clin North Am 2003; 32: 653-667
  • 14 Ebert A. Endometriose. Berlin: De Gruyter; 2003
  • 15 Schweppe K. Endometriose – Eine Erkrankung ohne Lobby. Zentralbl Gynakol 2003; 125: 233
  • 16 Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e.V. (AWMF). Interdisziplinäre S2k-Leitlinie für die Diagnostik und Therapie der Endometriose. Düsseldorf: AWMF; 2013
  • 17 Schindler AE. Operative und medikamentöse Therapie der Endometriose/Adenomyose. J Gynäkol Endokrinol 2008; 18: 18-26
  • 18 Garry R. The effectiveness of laparoscopic excision of endometriosis. Curr Opin Obstet Gynecol 2004; 16: 299-303
  • 19 Ulrich U, Buchweitz O, Greb R et al. German and Austrian Societies for Obstetrics and Gynecology. National German Guideline (S2k): Guideline for the diagnosis and treatment of endometriosis: long version - AWMF Registry No. 015-045. Geburtshilfe Frauenheilkd 2014; 74: 1104-1118
  • 20 Vercellini P, Aimi G, Busacca M et al. Laparoscopic uterosacral ligament resection for dysmenorrhea associated with endometriosis: results of a randomized, controlled trial. Fertil Steril 2003; 80: 310-319
  • 21 Jacobson TZ, Duffy JM, Barlow D et al. Laparoscopic surgery for subfertility associated with endometriosis. Cochrane Database Syst Rev 2010; (1) CD001398
  • 22 Sutton CJ, Ewen SP, Whitelaw N et al. Prospective, randomized, double-blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis. Fertil Steril 1994; 62: 696-700
  • 23 Shakiba K, Bena JF, McGill KM et al. Surgical treatment of endometriosis: a 7-year follow-up on the requirement for further surgery. Obstet Gynecol 2008; 111: 1285-1292
  • 24 Busacca M, Fedele L, Bianchi S et al. Surgical treatment of recurrent endometriosis: laparotomy versus laparoscopy. Hum Reprod 1998; 13: 2271-2274
  • 25 Hart RJ, Hickey M, Maouris P et al. Excisional surgery versus ablative surgery for ovarian endometriomata. Cochrane Database Syst Rev 2008; (2) CD004992
  • 26 Beretta P, Franchi M, Ghezzi F et al. Randomized clinical trial of two laparoscopic treatments of endometriomas: cystectomy versus drainage and coagulation. Fertil Steril 1998; 70: 1176-1180
  • 27 Chapron C, Fritel X, Dubuisson JB. Fertility after laparoscopic management of deep endometriosis infiltrating the uterosacral ligaments. Hum Reprod 1999; 14: 329-332
  • 28 Donnez J, Nisolle M, Gillet N et al. Large ovarian endometriomas. Hum Reprod 1996; 11: 641-646
  • 29 Busacca M, Vignali M. Endometrioma excision and ovarian reserve: a dangerous relation. J Minim Invasive Gynecol 2009; 16: 142-148
  • 30 Hwu YM, Wu FS, Li SH et al. The impact of endometrioma and laparoscopic cystectomy on serum anti-Müllerian hormone levels. Reprod Biol Endocrinol 2011; 9: 80
  • 31 Benaglia L, Somigliana E, Vighi V et al. Rate of severe ovarian damage following surgery for endometriomas. Hum Reprod 2010; 25: 678-682
  • 32 Müller A, Keller K, Wacker J et al. Retransplantation of cryopreserved ovarian tissue: the first live birth in Germany. Dtsch Arztebl Int 2012; 109: 8-13
  • 33 Chapron C. Management of deep endometriosis. WES E-Journal 2007; 3-6
  • 34 Chopin N, Vieira M, Borghese B et al. Operative management of deeply infiltrating endometriosis: results on pelvic pain symptoms according to a surgical classification. J Minim Invasive Gynecol 2005; 12: 106-112
  • 35 Possover M, Diebolder H, Plaul K et al. Laparascopically assisted vaginal resection of rectovaginal endometriosis. Obstet Gynecol 2000; 96: 304-307
  • 36 Vercellini P, Carmignani L, Rubino T et al. Surgery for deep endometriosis: a pathogenesis-oriented approach. Gynecol Obstet Invest 2009; 68: 88-103
  • 37 Wallwiener D, Jonat W, Kreienberg R et al. Atlas der gynäkologischen Operationen. 7. Aufl. Stuttgart: Thieme; 2009
  • 38 Darai E, Thomassin I, Barranger E et al. Feasibility and clinical outcome of laparoscopic colorectal resection for endometriosis. Am J Obstet Gynecol 2005; 192: 394-400
  • 39 Busacca M, Chiaffarino F, Candiani M et al. Determinants of long-term clinically detected recurrence rates of deep, ovarian, and pelvic endometriosis. Am J Obstet Gynecol 2006; 195: 426-432
  • 40 Minelli L, Fanfani F, Fagotti A et al. Laparoscopic colorectal resection for bowel endometriosis: feasibility, complications, and clinical outcome. Arch Surg 2009; 144: 234-239 discussion 239
  • 41 Keckstein J. Operative Therapie der Endometriose. Berlin: Kongress der DGGG; 2006
  • 42 Pérez-Utrilla Pérez M, Aguilera Bazán A, Alonso Dorrego JM et al. Urinary tract endometriosis: clinical, diagnostic, and therapeutic aspects. Urology 2009; 73: 47-51
  • 43 Donnez J, Squifflet J, Donnez O et al. Bladder Endometriosis. Atlas of operative Laparoscopy and Hysteroscopy. London: Informa UK Ltd.; 2007: 85-91
  • 44 Keckstein J, Ulrich U. Endokrine und operative Therapie der Adenomyose. Gynäkol Endokrinol 2004; 2: 11-18
  • 45 Osada H, Silber S, Kakinuma T et al. Surgical procedure to conserve the uterus for future pregnancy in patients suffering from massive adenomyosis. Reprod Biomed Online 2011; 22: 94-99
  • 46 Jacobson TZ, Barlow DH, Koninckx PR et al. Laparoscopic surgery for subfertility associated with endometriosis. Cochrane Database Syst Rev 2002; (4) CD001398
  • 47 Bianchi PHM, Pereira RMA, Zanatta A et al. Extensive excision of deep infiltrative endometriosis before in vitro fertilization significantly improves pregnancy rates. J Minim Invasive Gynecol 2009; 16: 174-180
  • 48 Chapron C, Fritel X, Dubuisson JB. Fertility after laparoscopic management of deep endometriosis infiltrating the uterosacral ligaments. Hum Reprod 1999; 14: 329-332
  • 49 Renner SP, Rix S, Boosz A et al. Preoperative pain and recurrence risk in patients with peritoneal endometriosis. Gynecol Endocrinol 2010; 26: 230-235
  • 50 Renner SP, Oppelt P, Binder H et al. Endometriose. Geburtsh Frauenheilk 2006; 66: R61-R88
  • 51 Busacca M, Somigliana E, Bianchi S et al. Post-operative GnRH analogue treatment after conservative surgery for symptomatic endometriosis stage III–IV: a randomized controlled trial. Hum Reprod 2001; 16: 2399-2402
  • 52 Hornstein MD, Yuzpe AA, Burry KA et al. Prospective randomized double-blind trial of 3 versus 6 months of nafarelin therapy for endometriosis associated pelvic pain. Fertil Steril 1995; 63: 955-962
  • 53 Vercellini P, Crosignani PG, Fadini R et al. A gonadotrophin-releasing hormone agonist compared with expectant management after conservative surgery for symptomatic endometriosis. Br J Obstet Gynaecol 1999; 106: 672-677
  • 54 Hornstein MD, Hemmings R, Yuzpe AA et al. Use of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis. Fertil Steril 1997; 68: 860-864
  • 55 Sallam H, Garcia-Velasco JA, Dias S et al. Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis. Cochrane Database Syst 2006; (1) CD004635
  • 56 Moore J, Kennedy S, Prentice A. Modern combined oral contraceptives for pain associated with endometriosis. Cochrane Database Syst Rev 2000; (2) CD001019
  • 57 Zupi E, Marconi D, Sbracia M et al. Add-back therapy in the treatment of endometriosis-associated pain. Fertil Steril 2004; 82: 1303-1308
  • 58 Fedele L, Berlanda N. Emerging drugs for endometriosis. Expert Opin Emerg Drugs 2004; 9: 167-177
  • 59 Regidor PA, Regidor M, Schmidt M et al. Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis. Gynecol Endocrinol 2001; 15: 202-209
  • 60 Telimaa S, Ronnberg L, Kauppila A. Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis after conservative surgery. Gynecol Endocrinol 1987; 1: 363-371
  • 61 Dawood MY, Obasiolu CW, Ramos J et al. Clinical, endocrine, and metabolic effects of two doses of gestrinone in treatment of pelvic endometriosis. Am J Obstet Gynecol 1997; 176: 387-394
  • 62 Strowitzki T, Faustmann T, Gerlinger C et al. Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol 2010; 151: 193-198
  • 63 Strowitzki T, Faustmann T, Gerlinger C et al. Safety and tolerability of dienogest in endometriosis: pooled analysis from the European clinical study program. Int J Womens Health 2015; 7: 393-401
  • 64 Allen C, Hopewell S, Prentice A. Non-steroidal anti-inflammatory drugs for pain in women with endometriosis. Cochrane Database Syst Rev 2005; (4) CD004753