Tetranorlabdane Diterpenoids from the Deep Sea Sediment-Derived Fungus Aspergillus wentii SD-310

Abstract

Two new tetranorlabdane diterpenoids, asperolides D (1) and E (2), along with six related known congeners (3–8), were isolated and identified from the culture extract of the deep sea sediment-derived fungus Aspergillus wentii SD-310. The structures of these compounds were established on the basis of spectroscopic interpretation, and the skeleton and absolute configurations of asperolides D (1) and E (2) were determined by X-ray crystallographic analysis. Compounds 1 and 2 were evaluated for their cytotoxic activity against seven tumor cell lines and antibacterial activity against two human and eight aquatic pathogens.

Key words

Aspergillus wentii - Trichocomaceae - marine-derived fungus - tetranorlabdane diterpenoids - cytotoxic activity - antibacterial activity

• References

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