Neuroendokrines Karzinom des Analkanals: Eine seltene Differenzialdiagnose

Fazit

Der demonstrierte Fall einer Patientin mit inguinal metastasiertem NEC des Analkanals spiegelt ein individualisiertes adjuvantes Therapieschema für die seltene Entität eines NEC des Analkanals wider. Auch wenn keine durch prospektive Studien gesicherten Empfehlungen zur adjuvanten Therapie bei GEP-NEC vorliegen, sprachen der Nachweis einer inguinalen Metastasierung mit Tumorthrombus in der V. femoralis und der mikroskopische Nachweis von Tumorzellen in den inguinalen Resektionsrändern bei hochproliferativem NEC für die Durchführung einer adjuvanten Therapie. Diese bestand aus einer Kombinationschemotherapie mit Cisplatin und Etoposid sowie einer lokalen Radiotherapie der Leistenregion. Dieses individualisierte Vorgehen führte dazu, dass die Patientin 8 Monate nach Operation lebt.

• Literatur

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