Endoscopy 2016; 48(S 01): E59-E60
DOI: 10.1055/s-0042-100197
Cases and Techniques Library (CTL)
© Georg Thieme Verlag KG Stuttgart · New York

Over-the-scope clip-assisted endoscopic full-thickness resection after incomplete resection of rectal adenocarcinoma

Pavlos Lagoussis
1   Division of General Surgery I, IRCCS Policlinico San Donato, San Donato Milanese, Italy
,
Paola Soriani
2   Gastroenterology and Digestive Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese, Italy
,
Gian Eugenio Tontini
2   Gastroenterology and Digestive Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese, Italy
,
Helmut Neumann
3   Department of Medicine I, University of Erlangen-Nuremberg, Erlangen, Germany
,
Luca Pastorelli
2   Gastroenterology and Digestive Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese, Italy
4   Department of Biomedical Sciences for Health, University of Milan, Milan, Italy
,
Germana de Nucci
5   Gastroenterology and Digestive Endoscopy Unit, A.O. Salvini, Garbagnate Milanese, Italy
,
Maurizio Vecchi
2   Gastroenterology and Digestive Endoscopy Unit, IRCCS Policlinico San Donato, San Donato Milanese, Italy
4   Department of Biomedical Sciences for Health, University of Milan, Milan, Italy
› Author Affiliations
Further Information

Corresponding author

Paola Soriani, MD
IRCCS Policlinico San Donato – Gastroenterology & Digestive Endoscopy Unit
Via Morandi 30
San Donato Milanese
Milano 20097
Italy   
Fax: +39-02-52774655    

Publication History

Publication Date:
18 February 2016 (online)

 

Endoscopic resection is a valuable therapeutic option for early colorectal cancer (CRC), especially in high risk surgical patients [1]. A novel endoscopic full-thickness resection device (FTRD; Ovesco Endoscopy, Tübingen, Germany) has been developed recently to achieve complete endoscopic resection of early CRC [2] [3].

Here, we report the case of a 78-year-old man with a history of coronary artery disease and recent pulmonary embolism being treated with anticoagulant therapy who underwent colonoscopy for hematochezia. A 3-cm non-pedunculated colorectal polyp with with Kudo V pit pattern was observed 5 cm above the dentate line ([Fig. 1]). An en bloc endoscopic mucosal resection was performed. Histology revealed adenocarcinoma (pT1 G2 Sm3) with a positive resection margin (0.7 mm) and deep submucosal invasion (1.4 mm). Total body computed tomography (CT) and rectal endoscopic ultrasound (EUS) showed no lymphatic or metastatic disease.

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Fig. 1 Endoscopic view showing the 3-cm non-pedunculated rectal polyp

Because of the patient’s comorbidities, we used the FTRD to achieve an R0 resection ([Video 1]) after he had received antibiotic prophylaxis with an intravenous cephalosporin. The last dose of low-molecular-weight heparin was administered 12 hours before the procedure. The lateral margins of the scarred resection site ([Fig. 2 a]) were marked with argon plasma coagulation (APC). The FTRD was mounted on the tip of an operative gastroscope and, through a tissue anchor, the whole scarred lesion was pulled into the cap and a modified 14-mm over-the-scope clip (OTSC) was deployed. The pseudopolyp created by the OTSC was resected using the preloaded snare and a standard electrosurgical setting (VIO; ERBE Elektromedizin GmbH, Tübingen, Germany) ([Fig. 2 b]). The procedure took about 8 minutes and there were no complications. Low-molecular-weight heparin was re-introduced 24 hours after the procedure and the patient was discharged.

The full-thickness resection device (FTRD) is shown being used to achieve an R0 resection in the rectum: the lateral margins are marked with argon plasma coagulation (APC) and a modified 14-mm over-the-scope clip (OTSC) is deployed to create a pseudopolyp that is resected using the preloaded snare and a standard electrosurgical setting.

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Fig. 2 Endoscopic views 3 months after the first endoscopic mucosal resection showing: a the scarred resection site (approximately 15 mm); b the immediate appearance after the full-thickness resection, with the over-the-scope-clip (OTSC) completely sealing the rectal wall defect.

The full-thickness specimen 15 mm in size ([Fig. 3]) was subjected to histological analysis, which revealed no remnant dysplasia ([Fig. 4]). This outcome was confirmed in the biopsy samples taken from the rectal scar 3 months later ([Fig. 5]). EUS and CT further confirmed the absence of any disease, and it was decided that no chemotherapy was required.

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Fig. 3 Photograph of the rectal full-wall resection specimen (luminal view).
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Fig. 4 Histopathological specimen of full-wall resection showing all the layers of the gut, with no dysplastic or neoplastic tissue.
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Fig. 5 Endoscopic view showing the scarred resection site 3 months after the full-thickness resection.

This case illustrates firstly the feasibility of full-thickness endoscopic resection of early CRC in the distal rectum, where standard surgery would carry considerable risks and require aggressive strategies. Secondly, we evaluated the potential of the novel FTRD in a high risk patient with ongoing anticoagulant therapy, for the first time reporting in detail the long-term clinical and endoscopic outcomes of this advanced endoscopic treatment.

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Competing interests: None


Corresponding author

Paola Soriani, MD
IRCCS Policlinico San Donato – Gastroenterology & Digestive Endoscopy Unit
Via Morandi 30
San Donato Milanese
Milano 20097
Italy   
Fax: +39-02-52774655    


Zoom
Fig. 1 Endoscopic view showing the 3-cm non-pedunculated rectal polyp
Zoom
Fig. 2 Endoscopic views 3 months after the first endoscopic mucosal resection showing: a the scarred resection site (approximately 15 mm); b the immediate appearance after the full-thickness resection, with the over-the-scope-clip (OTSC) completely sealing the rectal wall defect.
Zoom
Fig. 3 Photograph of the rectal full-wall resection specimen (luminal view).
Zoom
Fig. 4 Histopathological specimen of full-wall resection showing all the layers of the gut, with no dysplastic or neoplastic tissue.
Zoom
Fig. 5 Endoscopic view showing the scarred resection site 3 months after the full-thickness resection.