J Pediatr Intensive Care
DOI: 10.1055/s-0041-1742252
Original Article

Therapeutic Plasma Exchange in Pediatric Patients: Results from a Single Center

1   Department of Pediatric Intensive Care, Necip Fazil City Hospital, Kahramanmaras, Turkey
,
2   Department of Pediatrics, Necip Fazil City Hospital, Kahramanmaras, Turkey
,
Sevcan Ipek
3   Department of Pediatrics, Faculty of Medicine, Kahramanmaras Sütçü İmam University, Kahramanmaras, Turkey
,
Ufuk Utku Güllü
3   Department of Pediatrics, Faculty of Medicine, Kahramanmaras Sütçü İmam University, Kahramanmaras, Turkey
,
Yasar Kandur
4   Department of Pediatric Nephrology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey
,
Can Acipayam
5   Department of Pediatric Hematology and Oncology, Faculty of Medicine, Kahramanmaras Sütçü İmam University, Kahramanmaras, Turkey
,
Cengiz Dilber
6   Department of Pediatric Neurology, Faculty of Medicine, Kahramanmaras Sütçü İmam University, Kahramanmaras, Turkey
› Author Affiliations
Funding None.

Abstract

Therapeutic plasma exchange (TPE) can be applied as an effective therapeutic option in children with hematological, neurological, nephrological, and autoimmune/rheumatic disorders. We aimed to report our TPE experience in pediatric patients. In this article, we retrospectively reviewed the records of pediatric patients who underwent TPE between 2019 and 2021. A total of 128 TPE sessions were performed in 25 patients (13 males,12 females; mean age 59.6 ± 11.7 [3–198] months). The TPE indications were sepsis with/without multiorgan dysfunction syndrome in five patients, acute liver failure, hemolytic uremic syndrome caused by Shiga toxin, and autoimmune hemolytic anemia in three patients, respectively, multiple sclerosis, autoimmune encephalitis, and multisystem inflammatory syndrome in children (MIS-C) in two patients each, and myasthenia gravis crisis, meningococcemia, hemolytic uremic syndrome caused by coronavirus disease 2019, hemophagocytic lymphohistiocytosis, autoimmune encephalitis, and metabolic disease (fatty acid oxidation defect, liver failure) in one patient each. Based on our findings, we proposed that the American Society for Apheresis criteria should be updated according to newly described clinical conditions such as MIS-C.

Authors' Contributions

T.D. and Y.K. contributed to analysis and drafted the manuscript. M.M., S.I., U.U.G., C.A., and C.D. helped evaluate subjects. Y.K. designed and critically revised the manuscript. All authors read and approved the manuscript.




Publication History

Received: 17 September 2021

Accepted: 08 December 2021

Article published online:
03 February 2022

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