Rare Presentations of Frontal Sinus Fungus Ball: A Systematic Review

Abstract

Introduction The sinus fungus ball is an agglomeration of debris and hyphae, mainly caused by Aspergillus fumigatus, within the paranasal sinus, commonly affecting a single sinus, and it only rarely affects the frontal sinus.

Objective To identify the state of the art of fungus ball in paranasal sinuses, especially related to the epidemiology of the disease in the frontal sinus. Additionally, this article reports a rare case of fungus ball in the frontal sinus in an adult male, and discusses the variables of this condition related to the patient.

Data Synthesis All of the 8 cases of fungus ball in the frontal sinus reported in this study affected male patients: 40% had unilateral disease, and 60%, bilateral disease, contrary to the incidence data of fungus ball in the other paranasal sinuses, which reports unilateral prevalence. However, in the present study, this index changes, with 50% of unilateral and 50% of bilateral incidence regarding frontal sinus involvement. The average age of the patients was 65.36 years (range: 60-74 years). The etiologic agent was Aspergillus spp., and the endonasal endoscopic therapeutic approach corresponded to 80% of cases, while frontal osteoplasty accounted for 20% of cases, reaffirming the prevalence data from other studies.

Conclusion Despite being a low-incidence entity, frontal sinus fungus ball should be considered in patients with pain in the frontal region refractory to the usual clinical treatments.

Keywords

aspergillus fumigatus - communicable diseases - complications - transanal endoscopic surgery - paranasal sinus diseases

Introduction

The sinus fungus ball is defined as an agglomeration of debris and hyphae within the paranasal sinus, commonly affecting a single sinus.[1] It most commonly affects the maxillary sinus, followed by the sphenoid and ethmoid sinuses, and affection of the frontal sinus is extremely rare, comprising only ∼ 2% of all involved sinuses.[2] [3] [4] There is a slight predominance of female patients,[5] and, in most cases, it manifests during the fourth and fifth decades of life, as a result of respiratory infection by Aspergillus spp.[6]

Aspergillus fumigatus and Aspergillus flavus [6] are the main species involved in fungal rhinosinusitis. Aspergillus is a genus of anamorphic fungi which is characterized by having filamentous fungi with hyaline hyphae, septate and branched at an acute angle.[7] They thrive in warm climates such as those of tropical countries. Several species of Aspergillus spp. are important to humans due their ability to produce toxic metabolites, mainly A. fumigatus, which forms a fast-growing, bluish-green, and powdery colony. A. flavus, on the other hand, is a filamentous fungus that can produce aflatoxins and cyclopiazonic acid, which makes it toxic to the hosts.[8] [9]

Fungal rhinosinusitis comprises between 4% and 10% of surgical interventions in the paranasal sinuses, and can be subdivided into invasive and non-invasive.[10] [11] Non-invasive fungal rhinosinusitis is more common in immunocompetent patients,[12] classified as fungus ball or allergic fungal rhinosinusitis.[13]

The slow and oligosymptomatic development of fungus ball in the frontal sinus often leads to late diagnoses, with the first clinical signs being orbital or intracranial complications.[14] The diagnosis of fungus ball is difficult, occasionally made through computed tomography (CT) or magnetic resonance imaging (MRI).[5] [15] Surgery with an endonasal endoscopic approach is the treatment of choice.[2] [16]

The present systematic review aims to identify the state of the art of fungus ball in the paranasal sinuses, especially related to the epidemiology of the disease in the frontal sinus. Additionally, the present article reports a rare case of fungus ball in the frontal sinus in an adult male, and discusses the variables of this condition related to the patient.

Review of the Literature

The present is a systematic review and case report written following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) statement and its extensions, namely the one for equity-focused reviews (PRISMA-E 2012).[17] The Population, Intervention, Comparison and Outcome (PICO) system was also followed, but no specific protocols were used in its development.

A search was conducted on the PubMed/MEDLINE, ScienceDirect, BIREME, and Scielo databases by combining the keyword fungus ball with paranasal sinuses, fungal rhinosinusitis, and frontal sinus.

The database search ended on December 13, 2020, with an interval between the months of June and December of the same year.

The inclusion criteria were: prospective and retrospective studies on fungal rhinosinusitis (case reports) and fungus ball in human paranasal sinuses (review articles). The exclusion criteria were studies with in vitro or in animal models, or studies on topics other than that of the present article.

The data extraction process was conducted by two evaluators independently, and any disagreements were solved through consensus or by consulting a third evaluator. We used a pilot-tested spreadsheet developed for the study, in which the reviewers entered the variables of interest. The articles were extracted in duplicate and stored in the bibliographic management software Endnote version 2020 (Clarivate Analytics, Philadelphia, PA, US).

With the aforementioned combinations, 203 articles were found in PubMed/MEDLINE, 889 articles in ScienceDirect, 172 articles in BIREME, and 3 articles in Scielo. After applying the inclusion and exclusion criteria, we selected: 1 article from the Scielo database, 2 from BIREME, and 18 articles from PubMed/MEDLINE, totaling 16 articles on fungus ball in the maxillary, sphenoid, and ethmoid paranasal sinuses, and 5 articles on fungus ball in the frontal sinus. In accordance with the PRISMA-E 2012 statement, the flowchart of the stages of the systematic review can be found in [Fig. 1].

Fig. 1 Flowchart of the different stages of the systematic review.

The most recent studies on fungus ball in paranasal sinuses show the prevalence of fungus ball in paranasal sinuses in the age group of 50 to 60 years. Prospective studies reaffirm the prevalence of fungus ball in the maxillary sinus, followed by the sphenoid, ethmoid, and, finally, the frontal sinuses, reported in the retrospective studies, as well as a higher incidence of cases of unilateral disease and female patients, with the most prevalent etiological agent being Aspergillus spp. The unanimous therapeutic approach of choice is endonasal endoscopy in any affected paranasal sinus.

All the reported cases of fungus ball herein analyzed were in the frontal sinus and affected male patients, which is contrary to the common prevalence of female patients and cases of fungus ball in the other paranasal sinuses. As for thestatistical data, of the 8 patients with fungus ball in the frontal sinus, 40% had unilateral affection, and 60%, bilateral, which is also contrary to the incidence data for the other paranasal sinuses, which is of unilateral prevalence. However, in the present study, this index changes, with 50% of unilateral and 50% of bilateral incidence regarding frontal inus involvement.

As for the etiologic agent Aspergillus spp., the endonasal endoscopic therapeutic approach corresponded to 80% of the cases, while frontal osteoplasty accounted for 20% of the cases, reaffirming the prevalence data from other studies. The average age of the patients was 65.36 years, ranging from 60 to 74 years. [Table 1] shows a summary of the data of the reports herein analyzed.[2] [14] [18] [19] [20]

Table 1 Summary of the main data from the articles retrieved in the systematic review

Reference	Patients with fungus ball in the frontal sinus	Age at diagnosis (years)	Affected paranasal sinus	Affection (unilateral or bilateral)	Etiological agent
Bernardini et al.[2] (2017)	2	60; 65	Frontal	Bilateral	Aspergillus fumigatus
Popko et al.[14] (2010)	2	63; 74	Frontal	Bilateral	Aspergillus fumigatus
Seo et al.[18] (2019)	1	61.16	Frontal	Unilateral (left)	Aspergillus spp.
Wei et al.[19] (2016)	2	−	Frontal	Bilateral	Aspergillus spp.
Stevens[20] (1978)	1	69	Frontal	Unilateral (right)	Aspergillus fumigatus

As aforementioned, apart from the systematic review, the present aeticle is also a case report. In a specialized otolaryngology service, a 63-year-old immunocompetent man, with no comorbidities, had as main complaint of “stabbing” pain in the forehead, predominantly on the left side, which had started in the previous 2 months , with no evolution. During this period, the patient used antibiotics, anti-inflammatory drugs, and topical and systemic corticosteroids, with no improvement in his condition.

The initial hypotheses that guided the request for the first exams were of nasal tumors, as well as recurrent acute and chronic rhinosinusitis. There were no abnormalities in the blood and serological tests. The endoscopic examination of the nasal cavity revealed mucosal edema with purulent secretion of the ostiomeatal complex. A CT scan of the paranasal sinuses identified veiling of the frontal sinus with microcalcifications, and hyperattenuating areas associated with bone wall sclerosis, suggestive of fungal bolus ([Figs. 2] and [3]). As these CT findings are typical of fungus balls, there were no differential diagnoses.

Fig. 2 Computed tomography scan in sagittal view showing obliteration with frontal sinus microcalcifications.

Fig. 3 Computed tomography scan in coronal view showing complete and heterogeneous left opacification of the frontal sinus.

The patient underwent maxillary sinusectomy, wide ethmoidectomy, and frontal sinusectomy in accordance with type IIa on the Draf classification, with complete removal of the lesion ([Fig. 4]). [Fig. 5] shows the endoscopic image of the frontal sinus after removal of a fungus ball. The histologic examination showed sparse fragments of mucosa covered by respiratory epithelium, with edema of the lamina propria and a marked inflammatory infiltrate (lymphocytes, neutrophils, histiocytes, and plasma cells). Intraoperative samples were sent for culture examination. Abundant septate hyphae were dichotomized at an acute angle, compatible with Aspergillus spp., with no signs of malignancy, and the Grocott stain test result was positive for fungi. A biopsy of the healthy frontal sinus mucosa confirmed negative non-invasive fungus ball.

Fig. 4 Endoscopic removal of a fungus ball from the frontal sinus.

Fig. 5 Endoscopic image showing the frontal sinus after removal of a fungus ball.

The patient was prescribed: amoxicillin 500 mg, 1 tablet every 8 hours for 7 days; prednisolone 20 mg, 1 tablet every 12 hours for 5 days; nasal wash with saline 10 ml in each nostril 5 times a day for 30 days; and, if necessary, dipyrone 40 drops, up to every 6 hours, in case of pain.

There were no intraoperative nor postoperative complications. Currently, the patient has been follwed up for one year, and complete improvement of the condition has been observed. The postoperative follow-up was performed by endoscopic control within one year of the surgery, and the nasal patency was preserved without stenosis with Draf IIA sinus drainage. The patient was lost to follow-up right after this last update of his medical record, so it was not possible to photographically record the postoperative period.

Discussion

Globally, the prevalence of unilateral involvement of paranasal sinuses is higher than the bilateral involvement. However, in the present study this index, related to the frontal sinus fungus ball, is equivalent, corresponding to 50% of unilateral involvement and 50% of bilateral involvement, perhaps due to some anatomical alteration in the frontal sinus.

All reported cases of fungus ball in the frontal sinus affected male patients, which goes against the common reported prevalence of the female gender; a possibility for this gender difference may be hormonal. The average age of the reported cases was of 65.36 years (range: 60 to 74 years), which exceeds the age range commonly reported in other cases of fungus balls in the paranasal sinuses; the fact that it occured in older patients may be related to the delay in the proliferation of fungi, reaching more patients in this age group.[21]

The aerogenic hypothesis[22] suggests that fungal spores reach the mucosa by inhalation and acquire pathogenic capacity due to anaerobic conditions within the sinus.[4] Other authors[23] indicate that obstruction of the osteomeatal complex or chronic rhinosinusitis are predisposing factors for fungus ball. However, this theory does not explain the cases of fungus ball that affect the sphenoid or frontal sinuses.[23] [24] Not all patients with occluded frontal sinuses develop a fungus ball, which probably means that spores are not always able to reach the frontal sinus due to the complex anatomy of the frontal recess.[23] [24]

Of the several anatomical sinonasal variants that may be related to this pathogenesis, the presence of bullous shell was significantly associated with the development of fungus ball, as well as a narrow infundibulum and anatomical variations in the region of the ostiomeatal complex, known to cause sinus hypoventilation.[25] Concomitant to this, our patient's anterior ethmoidal cells obstructed the frontal recess, which may explain the pathophysiological mechanism.

Imaging plays an important role in the diagnosis of fungal sinus disease. The initial imaging study of choice in most cases is the CT scan. Due to the nonspecific nature of many of the imaging findings, CT scans alone cannot be relied on to make the diagnosis, which requires a high index of clinical suspicion. Another option is the MRI, which can better delineate invasive disease involving the soft tissues beyond the sinuses; therefore, the performance of MRI scans is recommended if malignancy is suspected.[14] [26] [27] In the case herein reported, only CT was used, as it offered sufficient diagnostic criteria to perform the therapeutic procedure, according to the preclinical and surgical evaluations.

Endonasal endoscopy is the therapeutic approach of choice for any condition affecting the paranasal sinuses, as the pharmacological treatment alone does not result in improvement. It was the approach used in 80% of the cases in the present study, while frontal osteoplasty was reserved only for those in whom the endonasal approach was not possible.

The extended frontal approaches, described by Draf, Lothrop and Gross, can improve the surgical results and long-term nasal patency of the frontal sinus.[27] [28] The Draf I procedure enables the endoscopic access to the frontal recess, and is recommended for cases in which the frontal sinus pathology persists despite the use of the conservative technique to access the infundibulum and the anterior ethmoidal region. This procedure involves complete removal of the posterior ethmoidal cells and the uncinate process. If present, obstructive anterior cells are removed.[29] [30] [31]

The Draf II procedure involves endoscopic frontal sinusotomy, and is recommended for patients with severe or chronic forms of frontal disease in whom removal of the inflammatory or benign neoformations in the middle frontal sinus has failed after the endoscopic access to the frontal recess. In the Draf IIA procedure, the frontal sinus floor is resected from the lamina papyracea to the middle turbinate, whereas in Draf IIB, the frontal sinus floor is resected from the lamina papyracea to the nasal septum. In both cases, the posterior limit of the resection is the ventral margin of the nasal fossa.[28] [29] [30] [31] Dissection involves the removal of the anterior face from the frontal recess; thus, the frontal ostium is increased to the maximum dimension.[28] [30]

Regarding the preference between the two techniques, Draf IIB was indicated when the initial opening of Draf IIA was considered insufficient and prone to postoperative stenosis, or when an additional access was required due to the presence of tumors and mucoceles.[30] [31] In the case herein reported, a second approach with Draf IIB was not necessary, as the nasal patency was preserved without stenosis after Draf IIA.

Finally, Draf III is a modification of the surgery idealized by Lothrop, and is indicated in case of severe, chronic sinusitis. This technique combines a bilateral Draf IIB procedure with resection of the frontal intersinus septum and a section of the nasal septum, which forms a common frontal cavity.[31] [32] For the sake of a more comprehensive discussion on the different approaches to the frontal sinus, it should be noted that there are minimally-invasive techniques to manage lesions that are not amenable to complete resection via the Draf type-II or -III approaches, such as the endoscopic orbital transposition[33] and transorbital approaches.[34]

Many important neurovascular structures are adjacent to the frontal sinus, putting the patient at risk of orbital and intracranial complications. Thus, early diagnosis and surgical intervention are essential.

The validity of the conclusion and statistical analysis regarding the frontal sinus mycetoma is affected due the small number of cases included in the present study and reported in the scientific literature, in which case reports predominate over studies with large samples.

Final Comments

The presence of a fungus ball in the frontal sinus, even if non-invasive, is potentially much more serious when compared with cases involving other sinuses. Despite its low incidence, frontal sinus fungus ball should be considered in patients with pain in the frontal region who do not respond to the usual clinical treatments. The present study demonstrated the general epidemiological characteristics of this condition, contributing to the update of this differential diagnosis in otorhinological care.

Conflict of Interests

The authors have no conflict of interests to declare.

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Publikationsverlauf

Eingereicht: 11. Februar 2021

Angenommen: 23. September 2021

Artikel online veröffentlicht:
27. Januar 2022