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J Neurol Surg A Cent Eur Neurosurg 2022; 83(06): 535-539
DOI: 10.1055/s-0041-1739226
Original Article

Comparative Analysis of Acute Levodopa Challenge Test and the Outcomes of Deep Brain Stimulation in Parkinson's Disease

Yusheng Chen
1   Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
,
Jie Zu
2   Parkinson Disease Center, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
,
Wei Zhang
2   Parkinson Disease Center, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
,
Chuanying Xu
2   Parkinson Disease Center, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
,
Guiyun Cui
2   Parkinson Disease Center, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
,
Chenchen Cui
2   Parkinson Disease Center, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
,
Qihua Xiao
2   Parkinson Disease Center, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
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Abstract

Background We study the correlation between the preoperative levodopa challenge test and the efficacy of deep brain stimulation (DBS) surgery in Parkinson's disease (PD).

Methods Fifty patients with PD who underwent DBS treatment in our hospital from October 2016 to October 2017 were enrolled in this study. Using the Unified Parkinson Disease Rating Scale-III (UPDRS-III) as an indicator, we analyzed the improvement in motor symptoms on the levodopa challenge test and by DBS surgery. We also discussed the correlation between the effects of the levodopa challenge test and DBS surgery.

Results There was no correlation between the results of the levodopa challenge test and DBS surgery. There was a linear correlation between muscle rigidity and bradykinesia, whereas the linear correlation between other symptoms was weak.

Conclusion The levodopa challenge test can be used as a screening tool for patients undergoing DBS surgery, and can predict the degree of improvement in muscle rigidity and bradykinesia surgery. However, the prediction of the degree of improvement of total motor symptoms is poor.

Keywords

parkinson's disease - acute levodopa challenge test - deep brain stimulation - motor symptoms

Ethical Approval

This study has been approved by the Ethics committee of the Affiliated Hospital of Xuzhou Medical University (XYFY2015-KL109–01).




Publication History

Received: 07 October 2020

Accepted: 23 April 2021

Article published online:
12 December 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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