Erratum: Therapeutic Potential of HIV Nosode 30c as Evaluated in A549 Lung Cancer Cells

The Editor has been made aware of some errors in the authors' selection of illustrations for [Figs. 2], [5] and [6] of the above article in Homeopathy, Volume 106, Number 4, 2017 (Doi: 10.1016/j.homp.2017.09.001). After following COPE guidelines to investigate the matter, the Editor is satisfied that these were inadvertent and honest errors, and which had no impact on the data or the validity of the article's conclusions.

The authors' corrections to the illustrations are indicated below:

[Fig. 2(B)] Image of Drug Dose 3 has been replaced.

[Fig. 5(B)] Image of Drug Dose 3 has been replaced.

[Fig. 6(B)] Image of 4 h treatment of A549 cells has been replaced. (C) Image of 0 h treatment of WRL-68 cells has been replaced.

Fig. 2 Morphological analysis of (A) A549 and (B) WRL-68 cells: A549 cells showed membrane blebbing, cell periphery shrinkage and rounding off of cells in the HIV 30c treatment group. WRL-68 cells showed normal cell architecture as compared to control set after HIV 30c treatment.

Fig. 5 (A) Depolarization of mitochondrial membrane potential (MMP): fluorescence intensity was reduced gradually at increasing HIV 30c doses, indicating gradual reduction of MMP in A549 cells. (B) No change was observed in depolarization of mitochondrial membrane potential (MMP) after WRL-68 cells were treated with HIV-nosode. (C) This indicated the reduction in proliferative property of A549 cells upon treatment with HIV 30c at the dose 3.5µL/100 µL media compared to that of the control plates at different time points. Lowest proliferation was reached at 24 h of treatment. (D) Data of proliferation assay indicated no significant amount of reduction in cell division of WRL-68 cells upon treatment with HIV 30c at dose 3.5µL/100 µL in the media compared to that of the control plates at different time points.

Fig. 6 (A) Migration assay: The clear zone in the control plate was reduced compared to the corresponding zone of the reference plate after the 24 h treatment. But in the case of the drug doses, the clear zone was increased compared to that seen in the reference plate. The graph represents the migratory distance of the cells with respect to the reference plate. The results are represented as mean ± SE (significance *p < 0.05). (B) Senescence assay: The induction of premature senescence was initiated at 12th h after drug treatment in A549 cells. (C) Induction of premature senescence was not observed up to 24 h after treatment of WRL-68 cells with HIV-nosode treatment.

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Artikel online veröffentlicht:
07. Oktober 2021