Planta Med 2021; 87(15): 1275
DOI: 10.1055/s-0041-1736863
Abstracts
8. Poster Contributions
8.4 Analytics, recent methodology and applications

Untargeted metabolomics sheds light on the secondary metabolism of Malpighiaceae family

H Mannochio-Russo
1   Institute of Chemistry, São Paulo State University, Araraquara, Brazil
2   Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, United States
,
R F de Ameida
3   Department of Biological Sciences, Feira de Santana State University, Feira de Santana, Brazil
,
Bueno PCP
4   Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany
,
A Bauermeister
2   Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, United States
,
A M Caraballo-Rodríguez
2   Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, United States
,
P C Dorrestein
2   Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, United States
,
V S Bolzani
1   Institute of Chemistry, São Paulo State University, Araraquara, Brazil
› Author AffiliationsThis research was funded by CNPq, the Brazilian Fulbright Commission, and FAPESP
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The chemical characterization of plant species with medicinal interest is one of the main bottlenecks for the discovery and development of new therapeutic agents inspired in natural products. Malpighiaceae family, for instance, although described for important biological properties, is still considered chemically underexplored [1]. Therefore, this study aimed to perform an untargeted metabolomic investigation of a dataset comprising leaves of 39 genera and 139 species from all the major phylogenetic groups currently accepted for the family. The extracts were analyzed by UHPLC-ESI-MS/MS, followed by multivariate data analysis, library searches, molecular networking, and cutting edge in silico tools to disclose the corresponded chemical space [2] [3]. Several metabolites were annotated, and our results show that classes and subclasses of compounds were specific to particular phylogenetic clades or genera, raising evolutionary hypotheses for the production of metabolites by different groups. Our systematic approach allows a step forward for the Malpighiaceae chemical characterization and chemosystematics, while the associated findings will certainly contribute to future drug discovery studies using natural products.



Publication History

Article published online:
13 December 2021

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  • References

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  • 3 Tripathi A. et al. Nature Chemical Biology, 2021, 17: 146–151.
    PubMed