Keywords
implants - osseointegration - surface topography
Introduction
The implant design factor that affects the rate as well as the extent of osseointegration
is implant surface characteristics.[1]
[2]
[3]
[4]
[5] The process of osseointegration is now well described both histologically and at
the cellular level. The adhesion of a fibrin blood clot and the population of the implant
surface by blood-derived cells and mesenchymal stem cells is orchestrated in a manner
that results in osteoid formation and its subsequent mineralization.[7]
[8]
[9]
A seamless progression of changing cell populations and elaboration and modification
of the tissue/implant interface eventually results in bone formation in direct contact
with the implant surface. Precisely how much of the implant surface directly contacts
the bone, how rapidly this bone accrual occurs, and the mechanical nature of the bone/implant
connection is influenced by the nature of the implant surface itself.[10]
The characteristics of the implant surface are implicated in this complex process
of osseointegration in several different ways.
Surface Roughness of Titanium Implants
Parameters such as implant surface topography and shape influence the surgical technique
used and are important for good clinical outcomes and the success of implants.[10]
Two types of responses are seen once the implant comes in contact with the surrounding
tissues.
-
Fibrous soft tissue capsule formation around the implant: Ideal biomechanical fixation
cannot be obtained with the formation of this capsule, it can lead to implant failure.
-
Direct bone–implant contact without a connective tissue layer hindrance (osseointegration):
Osseointegrated implants show a high success rate. This osseointegration depends on
several other factors such as surface characteristics and the composition of the implants.
Nano, micro, and macro roughness are three types of implant surfaces topographies.
-
The macro level is directly related to implant design, with implant threads and surface
treatments resulting in surface roughness of more than 10 m. This type of implant
surface results in mechanical interlocking between the implant and adjacent bone.
Disadvantages of a macroporous surface are high chances of peri-implantitis and ion
leakage.[11]
-
Moderate roughness (1–2 μm): It is defined as surface roughness in the range of 1
to 10 m. The maximum interlocking in between the implant and bone is found in these
implants.[12]
[13]
[14]
[15]
According to a study by Hansson et al, the ideal surface should have hemispherical
pits ∼1.5 m in depth and 4 m in diameter.[16] In cases of low volume or poor quality of surrounding bone, rough surface implants
should be used; in such conditions, high levels of bone to implant contact will allow
for higher loading. Similarly, short implants with a rough surface are used in cases
with short ridges, the results obtained were better than those compared with smooth
surface implants.[17]
[18]
These studies have indicated that implants with rough surfaces have better interaction
with the bone as compared with implants with smooth surfaces.[13]
[19] However, no clinical evidence could be found by the Cochrane collaboration that
demonstrated a particular surface treatment to be superior to the other.[20]
Surface characteristics in the nanometer range show increased osteoblast accumulation
and protein adsorption, which promote osseointegration.[21] Numerous techniques can be used for surface roughening of implants. These are described
below.
Titanium Plasma-Spraying
Rough implants are produced using the titanium plasma-spraying (TPS) method ([Fig. 1]).
Fig. 1 Titanium plasma-spraying (TPS) method.
This surface treatment causes an increase in the tensile strength at the bone to implant
interface.[14]
Limitations: Leached-out titanium particles have sometimes been found in the bone
adjacent to these implants.[22] Metal ions released from implants may be the product of dissolution, fretting, and
wear, and maybe a source of concern due to their potentially harmful local and systemic
carcinogenic effects.[23]
Grit Blasting
Grit blasting is blasting the implant surface with hardened ceramic particles such
as alumina, calcium phosphate particles, and titanium oxide. The particles pass from
a nozzle at a high velocity under compressed air. Alumina (Al2O3) is most commonly used and provides a surface roughness that depends on the size
of the particles.
A disadvantage of blasting is that the particles stick onto the surface of the implant
and may not be removed after acid passivation, ultrasonic cleaning, or sterilization.
These particles may invade the adjacent tissues and hinder the process of osseointegration
and decrease the corrosion resistance of titanium.[24]
Titanium oxide can be used for surface treatment of titanium implants, an average
size of 25 m (range: ∼1–2 m) of the rough surface is formed. Studies have shown increased
bone to implant contact in TiO-blasted implants as compared with machined surfaces.[25] Titanium dental implants roughening can also be done using calcium phosphates such
as hydroxyapatite, β-tricalcium phosphate, and mixtures.
Advantages: Particles are resorbable, which leads to a clean, textured, pure titanium
surface. Studies have shown lesser bone-to-implant contact of these surfaces as compared
with machined surfaces.[26]
[27] and equal when compared with other blasted surfaces.[28]
Acid Etching
The implant surface can be processed using strong acids such as HCl, H2SO4, HNO3, and HF. These acid-etching procedures make micro pits on the surface, 0.5 to 2 m
in diameter in size.[29]
[30] Acid etching of implant surfaces helps in osseointegration ([Fig. 2]).
Fig. 2 Acid etching of implant surfaces.
These surfaces are shown to increase the osteoconductive process that results in bone
formation on the implant surface.[31]
Titanium dental implants can also be treated using fluoride solutions. Soluble TiF4 species are formed when titanium reacts with fluoride; a microrough surface is formed.
This process provides double benefits as microroughness and incorporation of fluoride
ions into the implant surface is achieved. Both these characteristics help in osseointegration.[32]
[33] This procedure may further improve osseointegration by making the implant surface
bioactive.
Various studies have indicated that implants treated by dual acid etching surface
modification show a specific topography that enables them to attach to the fibrin
scaffold as well as promote the adhesion of osteogenic cells, which enhances bone
apposition.[34]
[35] Recent improvements in acid-etching methods have been shown to increase cell adhesion
and bone neoformation. High-temperature acid-etching produces a homogeneous microporous
surface with higher bone-to-implant contact than TPS surfaces in experimental studies.[36]
[37]
However, treatment of titanium using chemicals might create microcracks that reduce
its fatigue resistance and mechanical properties.[38]
Anodization
Micro- or nano-porous surfaces may be produced by potentiostatic or galvanostatic
anodization of titanium in strong acids (H2SO4, H3PO4, HNO3, HF) at a high current density (200 A/m2) or potential (100 V). Modifications in the microstructure and the crystallinity
of the titanium oxide layer are created by anodization. [39] The anodization is a complex process that depends on various parameters including
current density, the concentration of acids, electrolyte composition, and electrolyte
temperature. Anodized surfaces result in a strong reinforcement of the bone response
with higher values for biomechanical and histomorphometric tests in comparison to
machined surfaces.[40]
[41] A higher clinical success rate was observed for the anodized titanium implants in
comparison with turned titanium surfaces of similar shapes.[42]
Conclusion
Surface topography of dental implants and osseointegration go hand in hand in terms
of the short-term or long-term success of implants. Surface roughness plays an important
part in the quality as well as the rate of osseointegration of titanium dental implants.
Highly roughened implants (TPS/grit blasted) have been shown to favor mechanical anchorage
and primary fixation to bone. Topographies in the nanometer range have been used to
promote protein adsorption, osteoblastic cell adhesion, and the rate of bone tissue
healing in the peri-implant region. Hence, the knowledge of surface topography is
essential for the selection and placement of dental implants.
