J Pediatr Infect Dis 2021; 16(05): 194-199
DOI: 10.1055/s-0041-1731409
Original Article

Taxonomy of Pathogen Codetection in Pediatric Case Fatalities with Adenoviral Respiratory Infection

Emily K. Ninmer
1   Department of Pediatrics, Division of Pediatric Critical Care, University of Virginia School of Medicine, Charlottesville, Virginia, United States
,
Claire Stewart
2   Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, Ohio, United States
,
3   Division of Critical Care Medicine, Children's National Hospital, Washington, United States
,
4   Division of Pediatric Critical Care, Inova Children's Hospital, Falls Church, Virginia, United States
,
Natalia Martinez-Schlurman
5   Division of Pediatric Critical Care, University of Florida School of Medicine, Gainesville, Florida, United States
,
Robert P. Kavanagh
6   Division of Pediatric Critical Care, Penn State College of Medicine, Hershey, Pennsylvania, United States
,
7   Division of Pediatric Critical Care, University of California at Davis School of Medicine, Sacramento, California, United States
,
Michael C. McCrory
8   Division of Pediatric Critical Care, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States
,
9   Division of Pediatric Critical Care, Yale University School of Medicine, New Haven, Connecticut, United States
,
Anjali V. Subbaswamy
10   Division of Pediatric Critical Care, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States
,
11   Division of Pediatric Critical Care, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States
,
Mary Lynn Sheram
12   Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia, United States
,
12   Department of Pediatrics, Medical College of Georgia, Augusta University, Augusta, Georgia, United States
,
1   Department of Pediatrics, Division of Pediatric Critical Care, University of Virginia School of Medicine, Charlottesville, Virginia, United States
› Author Affiliations
Funding None.

Abstract

Objective The aim of this study was to determine the prevalence and taxonomy of pathogen codetection in pediatric case fatalities associated with adenoviral respiratory infection.

Methods This retrospective case series included 107 pediatric case fatalities associated with adenoviral respiratory infection.

Results We observed a high rate of pathogen codetection with broad diversity from both respiratory and nonrespiratory sources. We noted differences in codetection characteristics based on immune status; most notably that immunocompromised cases were more likely to have bacteremia and adenoviremia.

Conclusions In pediatric case fatalities associated with adenoviral respiratory infection, we observed a high degree of pathogen codetection.

Note

Study coordination and all data analyses were performed at the University of Virginia.




Publication History

Received: 05 December 2020

Accepted: 17 April 2021

Article published online:
16 July 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • References

  • 1 Pavia AT. Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis. Clin Infect Dis 2011; 52 (Suppl. 04) S284-S289
  • 2 Spaeder MC. Severe adenoviral respiratory infection in children. Intensive Care Med 2013; 39 (06) 1157-1158
  • 3 Lai CY, Lee CJ, Lu CY. et al; Taiwan Pediatric Infectious Disease Alliance. Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010-2011. PLoS One 2013; 8 (01) e53614
  • 4 Tylka JC, McCrory MC, Gertz SJ, Custer JW, Spaeder MC. Immunocompromised children with severe adenoviral respiratory infection. Crit Care Res Pract 2016; 2016: 9458230
  • 5 Spaeder MC, Stewart C, Sharron MP. et al. Adenoviral respiratory infection-associated mortality in children: a retrospective case series. J Pediatr Intensive Care 2020; DOI: 10.1055/s-0040-1718868.
  • 6 Chertow DS, Memoli MJ. Bacterial coinfection in influenza: a grand rounds review. JAMA 2013; 309 (03) 275-282
  • 7 Rehder KJ, Wilson EA, Zimmerman KO, Cunningham CK, Turner DA. Detection of multiple respiratory viruses associated with mortality and severity of illness in children. Pediatr Crit Care Med 2015; 16 (07) e201-e206
  • 8 Peebles PJ, Dhara R, Brammer L, Fry AM, Finelli L. Influenza-associated mortality among children - United States: 2007-2008. Influenza Other Respir Viruses 2011; 5 (01) 25-31
  • 9 Scheltema NM, Gentile A, Lucion F. et al; PERCH Study Group. Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series. Lancet Glob Health 2017; 5 (10) e984-e991
  • 10 Weiss SL, Fitzgerald JC, Pappachan J. et al; Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Global epidemiology of pediatric severe sepsis: the sepsis prevalence, outcomes, and therapies study. Am J Respir Crit Care Med 2015; 191 (10) 1147-1157