Tierarztl Prax Ausg G Grosstiere Nutztiere 2021; 49(03): 216
DOI: 10.1055/s-0041-1729391
Vorträge
Zoo- und Wildtiere

Peripheral nerve sheath tumors in goldfish (Carassius auratus) similar to human atypical neurofibroma

Authors

  • F Armando

    1   Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
    2   Department of Veterinary Medicine, Pathology Unit, University of Parma, Parma, Italy
    6   These authors contributed equally

  • C Pigoli

    3   Dipartimento di Medicina Veterinaria (DIMEVET), Università degli Studi di Milano, Lodi, Italy
    6   These authors contributed equally

  • M Gambini

    1   Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
    3   Dipartimento di Medicina Veterinaria (DIMEVET), Università degli Studi di Milano, Lodi, Italy
    6   These authors contributed equally

  • A Ghidelli

    4   Department of Veterinary Medicine, University of Parma, Parma, Italy

  • G Ghisleni

    3   Dipartimento di Medicina Veterinaria (DIMEVET), Università degli Studi di Milano, Lodi, Italy
    5   Biessea Laboratorio Analisi Veterinarie, Milano, Italy

  • A Corradi

    2   Department of Veterinary Medicine, Pathology Unit, University of Parma, Parma, Italy

  • B Passeri

    2   Department of Veterinary Medicine, Pathology Unit, University of Parma, Parma, Italy

  • M Caniatti

    3   Dipartimento di Medicina Veterinaria (DIMEVET), Università degli Studi di Milano, Lodi, Italy

  • V Grieco

    3   Dipartimento di Medicina Veterinaria (DIMEVET), Università degli Studi di Milano, Lodi, Italy

  • W Baumgärtner

    1   Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany

  • C Puff

    1   Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
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Introduction Cutaneous spindle cell tumors (SCTs) frequently occur in fishes, with peripheral nerve sheath tumors (PNSTs) being the most commonly reported neoplasms in goldfish. However, distinguishing PNSTs from other SCTs is not always possible relying only on routine cytological and histopathological findings. The aim of this study was to characterize 6 skin nodules of 6 cohabiting goldfish (Carassius auratus) resembling atypical neurofibromas in humans.

Materials and methods Skin nodules were characterized using cytology, histopathology, histochemistry, and immunohistochemistry (IHC).

Results Cytology and histopathology showed a SCT with nuclear atypia in all cases. Gomori’s reticulin stains revealed the presence of intratumoral basement membrane fragments. IHC displayed multifocal expression of the S100 protein and CNPase by tumor cells, intermingled with neurofilament-positive axons.

Conclusion Collectively, these findings were consistent with a PNST resembling atypical neurofibroma in humans, an entity not previously reported in goldfish. The present findings suggested that reticulin stain, and IHC for S100 protein and CNPase are useful for identification of PNSTs in this species.


Publication History

Article published online:
22 June 2021

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