Onkologie – Operative Therapie des Vulvakarzinoms – Wie viel Radikalität ist erforderlich?

Das Vulvakarzinom gehört mit einer Inzidenz von etwa 5 / 100 000 zu den selteneren gynäkologischen Tumorentitäten. Im Vergleich hierzu treten das Endometriumkarzinom (17,7 / 100 000) und Ovarialkarzinom (12,1 / 100 000) deutlich häufiger auf [1].

• Literatur

• 1 Robert Koch Institut und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e. V.. Krebs in Deutschland 2009/2010. 9. Ausgabe Berlin: 2013
• 2 Hampl M, Deckers-Figiel S, Hampl JA et al. New aspects of vulvar cancer: changes in localization and age of onset. Gynecol Oncol 2008; 109: 340-345
• 3 de Hullu JA, van der Zee AGJ. Surgery and radiotherapy in vulvar cancer. Crit Rev Oncol Hematol 2006; 60: 38-58
• 4 Höckel M, Dornhöfer N. Vulvovaginal reconstruction for neoplastic disease. Lancet Oncol 2008; 9: 559-568
• 5 Burke TW, Levenback C, Coleman SL et al. Surgical therapy of T1 and T2 vulvar carcinoma: further experience with radical wide excision and selective inguinal lymphadenectomy. Gynecol Oncol 1995; 57: 215-220
• 6 Chan JK, Sugiyama V, Pham H et al. Margin distance and other clinico-pathologic prognostic factors in vulvar carcinoma: a multivariate analysis. Gynecol Oncol 2007; 104: 636-641
• 7 Woelber L, Eulenburg C, Choschzick M et al. Prognostic role of lymph node metastases in vulvar cancer and implications for adjuvant treatment. Int J Gynecol Cancer 2012; 22: 503-508
• 8 Groenen SMA, Timmers PJ, Burger CW. Recurrence rate in vulvar carcinoma in relation to pathological margin distance. Int J Gynecol Cancer 2010; 20: 869-873
• 9 National German Guideline S2k: Diagnosis, Therapy and Follow up Care of Vulvar Cancer and its Precursors. AWMF Registry 2015, 015/059
• 10 Höckel M, Schmidt K, Bornmann K et al. Vulvar field resection: novel approach to the surgical treatment of vulvar cancer based on ontogenetic anatomy. Gynecol Oncol 2010; 119: 106-113
• 11 Mahner S, Jueckstock J, Hilpert F et al. Adjuvant therapy in lymph node-positive vulvar cancer: the AGO-CaRE-1 study. J Natl Cancer Inst 2015; 107: 2015
• 12 de Gregorio N, Ebner F, Schwentner L et al. The role of preoperative ultrasound evaluation of inguinal lymph nodes in patients with vulvar malignancy. Gynecol Oncol 2013; 131: 113-117
• 13 Hinten F, van den Einden LCG, Hendriks JCM et al. Risk factors for short- and long-term complications after groin surgery in vulvar cancer. Br J Cancer 2011; 105: 1279-1287
• 14 Van der Zee AGJ, Oonk MH, De Hullu JA et al. Sentinel node dissection is safe in the treatment of early-stage vulvar cancer. J Clin Oncol 2008; 26: 884-889
• 15 van Beekhuizen HJ, Auzin M, van den Einden LCG et al. Lymph node count at inguinofemoral lymphadenectomy and groin recurrences in vulvar cancer. Int J Gynecol Cancer 2014; 24: 773-778