Z Gastroenterol 2021; 59(01): e31-e32
DOI: 10.1055/s-0040-1722030
Poster Visit Session III Metabolism (incl. NAFLD)
Friday, January 29, 2021, 4:40 pm – 5:25 pm, Poster Session Virtual Venue

Lipoprotein and metabolic profiles indicate similar cardiovascular risk of liver steatosis and NASH

A Gottlieb
1   Johns Hopkins University School of Medicine, Physiology, Baltimore, United States
2   Otto-von-Guericke University Magdeburg, Gastroenterology, Hepatology, Infectious Diseases, Magdeburg, Germany
,
AS Leven
3   Alfried Krupp Hospital, Department for General- and Visceral Surgery, Essen, Germany
,
JP Sowa
2   Otto-von-Guericke University Magdeburg, Gastroenterology, Hepatology, Infectious Diseases, Magdeburg, Germany
4   University Hospital Knappschaftskrankenhaus Bochum, Ruhr, Department of Internal Medicine, Bochum, Germany
,
K Borucki
5   Otto-von-Guericke University Magdeburg, Institute for Clinical Chemistry and Pathobiochemistry, Magdeburg, Germany
,
A Link
2   Otto-von-Guericke University Magdeburg, Gastroenterology, Hepatology, Infectious Diseases, Magdeburg, Germany
,
E Yilmaz
6   INFAI GmbH, Cologne, Germany
,
S Aygen
6   INFAI GmbH, Cologne, Germany
,
A Canbay
4   University Hospital Knappschaftskrankenhaus Bochum, Ruhr, Department of Internal Medicine, Bochum, Germany
,
M Porsch-Özcürümez
4   University Hospital Knappschaftskrankenhaus Bochum, Ruhr, Department of Internal Medicine, Bochum, Germany
› Author Affiliations
 
 

    Question Non-alcoholic fatty liver disease (NAFLD) affects about 25 % of the global population, with no reliable non-invasive tests to diagnose non-alcoholic steatohepatitis (NASH) and to differ between NASH and NAFL (steatosis alone). It is unclear if NAFL and NASH differ in cardiovascular risk for patients. Here, we compared obese NAFLD patients with a healthy cohort, to test, whether cholesterol compounds could represent potential non-invasive markers and to estimate associated risks.

    Methods Serum samples of 46 patients with histologically confirmed NAFLD (17 NAFL, 29 NASH) that underwent bariatric surgery were compared to 32 (9 males, 21 female) healthy controls (HC). We analyzed epidemiological data, liver enzymes, cholesterol-, lipid- profile and amino acids. The latter were analyzed by nuclear magnetic resonance (NMR) spectroscopy.

    Results Total serum - and HDL- cholesterol were significantly lower in NAFLD groups than in HC with a stronger reduction in NASH. Similar observations were made for sub specification of HDL-p, HDL-s, SHDL-p, and LHDL-p cholesterols. LDL-s and LLDL-p cholesterol were significantly reduced in NAFLD groups. Interestingly, SLDL-p cholesterol was significantly higher in NAFL with a stronger elevation in NASH compared to HC. The amino acids alanine, leucin, and isoleucine were significantly higher in NAFL and NASH compared to HC.

    Conclusions We show in this study that cholesterol profiles, apolipoproteins and amino acids could function as a potential non-invasive test to screen for NAFLD or even NASH in larger populations. However, few differences in cholesterol profiles were identified between NAFL and NASH, indicating similar cardiovascular risk profiles.


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    Publication History

    Article published online:
    04 January 2021

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