Homœopathic Links 2021; 34(03): 206-213
DOI: 10.1055/s-0040-1714376
Review Article

Homoeopathy for Upper Respiratory Tract Infection in Children: A Narrative Review of Research Evidence

1   Department of Organon of Medicine, National Institute of Homoeopathy, Kolkata, West Bengal, India
,
Nisha Sehrawat
2   Department of Pediatrics, National Institute of Homoeopathy, Kolkata, West Bengal, India
› Author Affiliations

Abstract

Background Upper respiratory tract infection (URTI) is one of the leading causes of morbidity worldwide, especially in the paediatric age group. Conventional medications have a minimal role in treating and preventing those diseases and an alternative for this is warranted. In this regard, homoeopathy can be a proper consideration, but the comparative effect and safety need critical evaluation.

Methods To evaluate the role of homoeopathic treatment in URTI, particularly in children, we conducted a comprehensive search in PubMed, Core-Hom, Cochrane library and Cam-quest database. All the relevant studies were included for a critical review.

Results One-hundred forty articles were found in a preliminary search, and for review, we included 17 studies related to URTI in paediatric age group. All the studies were very diverse in the methodology, type of homoeopathy used and outcome measurement. Different types of homoeopathy in terms of individualised, complex syrup and home-medication were used in studies. Fourteen studies reported the role of homoeopathy in reducing the severity of symptoms, efficacy beyond placebo, superiority or non-inferiority over conventional medications, in lowering the consumption of antibiotics and as prophylaxis. On the other hand, three studies found little or no effect in reducing symptoms or number of visits.

Conclusions Homoeopathic treatment improves the symptoms and reduces the severity of URTI in the paediatric age group. It can be an effective and safe way of treatment for reducing the burden of the disease, thus improving the quality of life. Owing to the diversity among the studies, more high-quality trials with focused questions are needed for further conclusion.



Publication History

Article published online:
17 August 2020

© 2021. Thieme. All rights reserved.

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Thomas M, Bomar PA. . Upper Respiratory Tract Infection. In: StatPearls. [Internet].. Treasure Island (FL): StatPearls Publishing; 2019. [cited 2019 Dec 23]. Accessed June 21, 2020 from: http://www.ncbi.nlm.nih.gov/books/NBK532961/
  • 2 Kim D, Chen Z, Zhou L-F, Huang S-X. Air pollutants and early origins of respiratory diseases. Chronic Dis Transl Med 2018; 4 (02) 75-94
  • 3 Simoes EAF, Cherian T, Chow J, Shahid-Salles SA, Laxminarayan R, John TJ. Acute respiratory infections in children. In: Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB. et al., eds. Disease Control Priorities in Developing Countries [Internet]. 2nd edition. Washington (DC): World Bank; 2006. [cited 2019 Dec 23]. Accessed June 21, 2020 from: http://www.ncbi.nlm.nih.gov/books/NBK11786/
  • 4 WHO Model Prescribing Information. Drugs used in Bacterial Infections: Upper respiratory tract infections: Epiglottitis [Internet]. [cited 2019 Dec 23]. Accessed June 21, 2020 from: http://apps.who.int/medicinedocs/en/d/Js5406e/3.7.html
  • 5 Upper Respiratory Tract Infection Clinical Presentation. History, Physical Examination [Internet]. [cited 2019 Dec 23]. Accessed June 21, 2020 from: https://emedicine.medscape.com/article/302460-clinical
  • 6 Cotton M, Innes S, Jaspan H, Madide A, Rabie H. Management of upper respiratory tract infections in children. S Afr Fam Pract (2004) 2008; 50 (02) 6-12
  • 7 Belser JA, Rota PA, Tumpey TM. Ocular tropism of respiratory viruses. Microbiol Mol Biol Rev 2013; 77 (01) 144-156
  • 8 Schaad UB. Prevention of paediatric respiratory tract infections: emphasis on the role of OM-85. Eur Respir Rev 2005; 14 (95) 74-77
  • 9 Sarkar R, Sivarathinaswamy P, Thangaraj B. et al. Burden of childhood diseases and malnutrition in a semi-urban slum in southern India. BMC Public Health 2013; 13 (01) 87
  • 10 Upper RTI. . Practice Essentials, Background, Pathophysiology. 2019 Nov 12 [cited 2019 December 23]; Accessed June 21, 2020 from: https://emedicine.medscape.com/article/302460-overview
  • 11 Kumar SG, Majumdar A, Kumar V, Naik BN, Selvaraj K, Balajee K. Prevalence of acute respiratory infection among under-five children in urban and rural areas of Puducherry, India. J Nat Sci Biol Med 2015; 6 (01) 3-6
  • 12 The_Global_Impact_of_Respiratory_Disease.pdf [Internet]. [cited 2019 Dec 23]. Accessed June 21, 2020 from: https://www.who.int/gard/publications/The_Global_Impact_of_Respiratory_Disease.pdf
  • 13 Rhinovirus (RV) Infection. . (Common Cold): Practice Essentials, Background, Pathophysiology. 2019 November 9 [cited 2019 Dec 23]; Accessed June 21, 2020 from: https://emedicine.medscape.com/article/227820-overview
  • 14 Renati S, Linder JA. Necessity of office visits for acute respiratory infections in primary care. Fam Pract 2016; 33 (03) 312-317
  • 15 Broor S, Parveen S, Bharaj P. et al. A prospective three-year cohort study of the epidemiology and virology of acute respiratory infections of children in rural India. PLoS One 2007; 2 (06) e491
  • 16 Ramani VK, Pattankar J, Puttahonnappa SK. Acute respiratory infections among under-five age group children at urban slums of Gulbarga City: a longitudinal study. J Clin Diagn Res 2016; 10 (05) LC08-LC13
  • 17 Fendrick AM, Monto AS, Nightengale B, Sarnes M. The economic burden of non-influenza-related viral respiratory tract infection in the United States. Arch Intern Med 2003; 163 (04) 487-494
  • 18 Bramley TJ, Lerner D, Sames M. Productivity losses related to the common cold. J Occup Environ Med 2002; 44 (09) 822-829
  • 19 Pingel S. Homoeopathy. Basic aspects and principles of use in dermatology. Hautarzt Z Dermatol Venerol Verwandte Geb. 1992; 43 (08) 475-482
  • 20 American Institute of Homoeopathy - Homoeopathy [Internet]. [cited 2019 December 24]. Available from: https://homeopathyusa.org/Homeopathic-medicine.html
  • 21 About Homoeopathy [Internet]. NASH. [cited 2019 Dec 24]. Accessed June 21, 2020 from: https://homeopathy.org/about-homeopathy/
  • 22 de Lange de Klerk ES, Blommers J, Kuik DJ, Bezemer PD, Feenstra L. Effect of homoeopathic medicines on daily burden of symptoms in children with recurrent upper respiratory tract infections. BMJ 1994; 309 (6965): 1329-1332
  • 23 Steinsbekk A, Bentzen N, Fønnebø V, Lewith G. Self treatment with one of three self selected, ultramolecular homeopathic medicines for the prevention of upper respiratory tract infections in children. A double-blind randomized placebo controlled trial. Br J Clin Pharmacol 2005; 59 (04) 447-455
  • 24 Steinsbekk A, Fønnebø V, Lewith G, Bentzen N. Homeopathic care for the prevention of upper respiratory tract infections in children: a pragmatic, randomised, controlled trial comparing individualised homeopathic care and waiting-list controls. Complement Ther Med 2005; 13 (04) 231-238
  • 25 Trichard M, Chaufferin G, Nicoloyannis N. Pharmacoeconomic comparison between homeopathic and antibiotic treatment strategies in recurrent acute rhinopharyngitis in children. Homeopathy 2005; 94 (01) 3-9
  • 26 Steinsbekk A, Lewith G, Fønnebø V, Bentzen N. An exploratory study of the contextual effect of homeopathic care. A randomised controlled trial of homeopathic care vs. self-prescribed homeopathic medicine in the prevention of upper respiratory tract infections in children. Prev Med 2007; 45 (04) 274-279 , discussion 280–281
  • 27 Ramchandani NM. Homoeopathic treatment of upper respiratory tract infections in children: evaluation of thirty case series. Complement Ther Clin Pract 2010; 16 (02) 101-108
  • 28 Taylor JA, Jacobs J. Homeopathic ear drops as an adjunct in reducing antibiotic usage in children with acute otitis media. Glob Pediatr Health 2014; 1: X14559395
  • 29 Zanasi A, Cazzato S, Mazzolini M. et al. Does additional antimicrobial treatment have a better effect on URTI cough resolution than homeopathic symptomatic therapy alone? A real-life preliminary observational study in a pediatric population. Multidiscip Respir Med 2015; 10 (01) 25
  • 30 Jacobs J, Taylor JA. A randomized controlled trial of a homeopathic syrup in the treatment of cold symptoms in young children. Complement Ther Med 2016; 29: 229-234
  • 31 Jong MC, Buskin SL, Ilyenko L. et al. Effectiveness, safety and tolerability of a complex homeopathic medicinal product in the prevention of recurrent acute upper respiratory tract infections in children: a multicenter, open, comparative, randomized, controlled clinical trial. Multidiscip Respir Med 2016; 11: 19
  • 32 Pedrero-Escalas MF, Jimenez-Antolin J, Lassaletta L, Diaz-Saez G, Gavilán J. Hospital clinical trial: Homeopathy (Agraphis nutans 5CH, Thuya occidentalis 5CH, Kalium muriaticum 9CH and Arsenicum iodatum 9CH) as adjuvant, in children with otitis media with effusion. Int J Pediatr Otorhinolaryngol 2016; 88: 217-223
  • 33 Siqueira CM, Homsani F, da Veiga VF. et al. Homeopathic medicines for prevention of influenza and acute respiratory tract infections in children: blind, randomized, placebo-controlled clinical trial. Homeopathy 2016; 105 (01) 71-77
  • 34 van Haselen R, Thinesse-Mallwitz M, Maidannyk V. et al. The effectiveness and safety of a homoeopathic medicinal product in pediatric upper respiratory tract infections with fever. Glob Pediatr Health 2016; 3: 1-11
  • 35 Haidvogl M, Riley DS, Heger M. et al. Homeopathic and conventional treatment for acute respiratory and ear complaints: a comparative study on outcome in the primary care setting. BMC Complement Altern Med 2007; 7: 7
  • 36 Grimaldi-Bensouda L, Bégaud B, Rossignol M. et al. Management of upper respiratory tract infections by different medical practices, including homeopathy, and consumption of antibiotics in primary care: the EPI3 cohort study in France 2007-2008. PLoS One 2014; 9 (03) e89990
  • 37 Thinesse-Mallwitz M, Maydannik V, Keller T, Klement P. A homeopathic combination preparation in the treatment of feverish upper respiratory tract infections: an international randomized controlled trial. Forsch Komplement Med 2015; 22 (03) 163-170
  • 38 Beghi GM, Morselli-Labate AM. Does homeopathic medicine have a preventive effect on respiratory tract infections? A real life observational study. Multidiscip Respir Med 2016; 11: 12
  • 39 Ajimsha MS, Majeed NA, Chinnavan E, Thulasyammal RP. Effectiveness of autogenic training in improving motor performances in Parkinson's disease. Complement Ther Med 2014; 22 (03) 419-425
  • 40 Homoeopathic Medicine | Caring Ambassadors [Internet]. [cited 2019 Dec 23]. Available from: https://caringambassadors.org/healing/healthcare-options/complementary-medicine/homeopathic-medicine/
  • 41 Fashner J, Ericson K, Werner S. Treatment of the common cold in children and adults. Am Fam Physician 2012; 86 (02) 153-159
  • 42 Ekins-Daukes S, Helms PJ, Taylor MW, Simpson CR, McLay JS. Paediatric homoeopathy in general practice: where, when and why?. Br J Clin Pharmacol 2005; 59 (06) 743-749
  • 43 Bell IR, Boyer NN. Homeopathic medications as clinical alternatives for symptomatic care of acute otitis media and upper respiratory infections in children. Glob Adv Health Med 2013; 2 (01) 32-43
  • 44 Reid S. A survey of the use of over-the-counter homeopathic medicines purchased in health stores in central Manchester. Homeopathy 2002; 91 (04) 225-229
  • 45 Zanasi A, Mazzolini M, Tursi F, Morselli-Labate AM, Paccapelo A, Lecchi M. Homeopathic medicine for acute cough in upper respiratory tract infections and acute bronchitis: a randomized, double-blind, placebo-controlled trial. Pulm Pharmacol Ther 2014; 27 (01) 102-108
  • 46 Organon 140–159 [Internet]. [cited 2019 December 24]. Accessed June 21, 2020 from: http://homeoint.org/books/hahorgan/organ140.htm#P148E5
  • 47 Kenealy T, Arroll B. Antibiotics for the common cold and acute purulent rhinitis. Vol. 2013, Cochrane Database of Systematic Reviews. John Wiley and Sons Ltd; 2013
  • 48 Heikkinen T, Ruuskanen O. Upper respiratory tract infection. In: Encyclopedia of Respiratory Medicine. Academic Press; 2006;385–388
  • 49 Lassi ZS, Mallick D, Das JK, Mal L, Salam RA, Bhutta ZA. Essential interventions for child health. Reprod Health 2014; 11 (Suppl. 01) S4
  • 50 Li YR, Xiao CC, Li J. et al. Association between air pollution and upper respiratory tract infection in hospital outpatients aged 0-14 years in Hefei, China: a time series study. Public Health 2018; 156: 92-100
  • 51 Hegazy NN, Mahrous OAE, Salah MA. An overview of respiratory tract infections in preschool children in primary healthcare. Menoufia Med. J 2018;31(03):862–866
  • 52 Viksveen P. Antibiotics and the development of resistant microorganisms. Can homeopathy be an alternative?. Homeopathy 2003; 92 (02) 99-107