Semin intervent Radiol 2020; 37(03): 250-262
DOI: 10.1055/s-0040-1713442
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Nodal and Pedal MR Lymphangiography of the Central Lymphatic System: Techniques and Applications

Claus Christian Pieper
1   Department of Diagnostic and Interventional Radiology, Faculty of Medicine, University Hospital Bonn, Bonn, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
31 July 2020 (online)

Abstract

Novel lymphatic imaging and interventional techniques are increasingly used in the diagnostic workup and treatment of pathologies of the central lymphatic system and have opened a new field of interventional radiology. The mainstay of lymphatic imaging today is magnetic resonance lymphangiography (MRL). It provides information on the anatomy of the central lymphatic system, lymphatic flow, as well as lymphatic pathologies and therefore is a valuable tool for treatment planning. There are two techniques to perform contrast-enhanced MRL: nodal dynamic contrast-enhanced MRL (nodal DCE-MRL) and interstitial transpedal MRL (tMRL). Nodal DCE-MRL yields superior information on lymphatic flow dynamics and is therefore best suited for suspected lymphatic flow pathologies and lymphatic malformations. tMRL is a technically simpler alternative for central lymphatic visualization without the need for sonographically guided lymph node cannulation. This review article describes current MRL techniques with a focus on contrast-enhanced MRL, their specific advantages, and possible clinical applications in patients suffering from pathologies of the central lymphatic system.

 
  • References

  • 1 Clément O, Luciani A. Imaging the lymphatic system: possibilities and clinical applications. Eur Radiol 2004; 14 (08) 1498-1507
  • 2 Pieper CC, Hur S, Sommer CM. , et al. Back to the future: lipiodol in lymphography-from diagnostics to theranostics. Invest Radiol 2019; 54 (09) 600-615
  • 3 Schild HH, Strassburg CP, Welz A, Kalff J. Treatment options in patients with chylothorax. Dtsch Arztebl Int 2013; 110 (48) 819-826
  • 4 Schild HH, Naehle CP, Wilhelm KE. , et al. Lymphatic interventions for treatment of chylothorax. RoFo Fortschr Geb Rontgenstr Nuklearmed 2015; 187 (07) 584-588
  • 5 Itkin M, Kucharczuk JC, Kwak A, Trerotola SO, Kaiser LR. Nonoperative thoracic duct embolization for traumatic thoracic duct leak: experience in 109 patients. J Thorac Cardiovasc Surg 2010; 139 (03) 584-589 , discussion 589–590
  • 6 Nadolski GJ, Itkin M. Thoracic duct embolization for nontraumatic chylous effusion: experience in 34 patients. Chest 2013; 143 (01) 158-163
  • 7 Cope C, Salem R, Kaiser LR. Management of chylothorax by percutaneous catheterization and embolization of the thoracic duct: prospective trial. J Vasc Interv Radiol 1999; 10 (09) 1248-1254
  • 8 Pieper CC, Schild HH. Interstitial transpedal MR-lymphangiography of central lymphatics using a standard MR contrast agent: feasibility and initial results in patients with chylous effusions. RoFo Fortschr Geb Rontgenstr Nuklearmed 2018; 190 (10) 938-945
  • 9 Nadolski GJ, Itkin M. Feasibility of ultrasound-guided intranodal lymphangiogram for thoracic duct embolization. J Vasc Interv Radiol 2012; 23 (05) 613-616
  • 10 Kerlan Jr RK, Laberge JM. Intranodal lymphangiography: coming soon to a hospital near you. J Vasc Interv Radiol 2012; 23 (05) 617
  • 11 Mitsumori LM, McDonald ES, Wilson GJ, Neligan PC, Minoshima S, Maki JH. MR lymphangiography: how I do it. J Magn Reson Imaging 2015; 42 (06) 1465-1477
  • 12 Dori Y. Novel lymphatic imaging techniques. Tech Vasc Interv Radiol 2016; 19 (04) 255-261
  • 13 Krishnamurthy R, Hernandez A, Kavuk S, Annam A, Pimpalwar S. Imaging the central conducting lymphatics: initial experience with dynamic MR lymphangiography. Radiology 2015; 274 (03) 871-878
  • 14 Pieper CC, Feisst A, Schild HH. Contrast-enhanced interstitial transpedal MR-lymphangiography for thoracic chylous effusions. Radiology 2020; 295 (02) 458-466
  • 15 Pimpalwar S, Chinnadurai P, Chau A. , et al. Dynamic contrast enhanced magnetic resonance lymphangiography: categorization of imaging findings and correlation with patient management. Eur J Radiol 2018; 101: 129-135
  • 16 Morris B. The exchange of protein between the plasma and the liver and intestinal lymph. Q J Exp Physiol Cogn Med Sci 1956; 41 (03) 326-340
  • 17 Geschwind JFH, Dake MD. Abrams' Angiography. 3rd ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2014
  • 18 Pinto PS, Sirlin CB, Andrade-Barreto OA, Brown MA, Mindelzun RE, Mattrey RF. Cisterna chyli at routine abdominal MR imaging: a normal anatomic structure in the retrocrural space. Radiographics 2004; 24 (03) 809-817
  • 19 Johnson OW, Chick JF, Chauhan NR. , et al. The thoracic duct: clinical importance, anatomic variation, imaging, and embolization. Eur Radiol 2016; 26 (08) 2482-2493
  • 20 Hong JY, Han K, Jung JH, Kim JS. Association of exposure to diagnostic low-dose ionizing radiation with risk of cancer among youths in South Korea. JAMA Netw Open 2019; 2 (09) e1910584
  • 21 Notohamiprodjo M, Weiss M, Baumeister RG. , et al. MR lymphangiography at 3.0 T: correlation with lymphoscintigraphy. Radiology 2012; 264 (01) 78-87
  • 22 Lohrmann C, Felmerer G, Foeldi E, Bartholomä JP, Langer M. MR lymphangiography for the assessment of the lymphatic system in patients undergoing microsurgical reconstructions of lymphatic vessels. Microvasc Res 2008; 76 (01) 42-45
  • 23 Food and Drug Administration (FDA). Gadavist prescribing information. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/201277s000lbl.pdf . Accessed May 20, 2020
  • 24 Derhy S, El Mouhadi S, Ruiz A, Azizi L, Menu Y, Arrivé L. Non-contrast 3D MR lymphography of retroperitoneal lymphatic aneurysmal dilatation: a continuous spectrum of change from normal variants to cystic lymphangioma. Insights Imaging 2013; 4 (06) 753-758
  • 25 Dori Y, Keller MS, Fogel MA. , et al. MRI of lymphatic abnormalities after functional single-ventricle palliation surgery. AJR Am J Roentgenol 2014; 203 (02) 426-431
  • 26 Okuda I, Udagawa H, Takahashi J, Yamase H, Kohno T, Nakajima Y. Magnetic resonance-thoracic ductography: imaging aid for thoracic surgery and thoracic duct depiction based on embryological considerations. Gen Thorac Cardiovasc Surg 2009; 57 (12) 640-646
  • 27 Erden A, Fitoz S, Yagmurlu B, Erden I. Abdominal confluence of lymph trunks: detectability and morphology on heavily T2-weighted images. AJR Am J Roentgenol 2005; 184 (01) 35-40
  • 28 Malone LJ, Fenton LZ, Weinman JP, Anagnost MR, Browne LP. Pediatric lymphangiectasia: an imaging spectrum. Pediatr Radiol 2015; 45 (04) 562-569
  • 29 Dori Y, Zviman MM, Itkin M. Dynamic contrast-enhanced MR lymphangiography: feasibility study in swine. Radiology 2014; 273 (02) 410-416
  • 30 Nadolski GJ, Ponce-Dorrego MD, Darge K, Biko DM, Itkin M. Validation of the position of injection needles with contrast-enhanced ultrasound for dynamic contract-enhanced MR lymphangiography. J Vasc Interv Radiol 2018; 29 (07) 1028-1030
  • 31 Chavhan GB, Amaral JG, Temple M, Itkin M. MR lymphangiography in children: technique and potential applications. Radiographics 2017; 37 (06) 1775-1790
  • 32 Hong Y, Xiang L, Hu Y, Zhou Z, Yu H, Zhu B. Interstitial magnetic resonance lymphography is an effective diagnostic tool for the detection of lymph node metastases in patients with cervical cancer. BMC Cancer 2012; 12: 360
  • 33 Lohrmann C, Pache G, Felmerer G, Foeldi E, Schaefer O, Langer M. Posttraumatic edema of the lower extremities: evaluation of the lymphatic vessels with magnetic resonance lymphangiography. J Vasc Surg 2009; 49 (02) 417-423
  • 34 Sena LM, Fishman SJ, Jenkins KJ. , et al. Magnetic resonance lymphangiography with a nano-sized gadolinium-labeled dendrimer in small and large animal models. Nanomedicine (Lond) 2010; 5 (08) 1183-1191
  • 35 Staatz G, Nolte-Ernsting CC, Adam GB. , et al. Interstitial T1-weighted MR lymphography: lipophilic perfluorinated gadolinium chelates in pigs. Radiology 2001; 220 (01) 129-134
  • 36 Turkbey B, Kobayashi H, Hoyt Jr RF. , et al. Magnetic resonance lymphography of the thoracic duct after interstitial injection of gadofosveset trisodium: a pilot dosing study in a porcine model. Lymphat Res Biol 2014; 12 (01) 32-36
  • 37 Majdalany BS, Murrey DA, Kapoor BS. , et al. ACR Appropriateness Criteria: Chylothorax Treatment Planning. Available at: https://www.acr.org/Quality-Safety/Appropriateness-Criteria/New-and-Revised . Accessed October 1, 2017
  • 38 Caliendo MV, Lee DE, Queiroz R, Waldman DL. Sclerotherapy with use of doxycycline after percutaneous drainage of postoperative lymphoceles. J Vasc Interv Radiol 2001; 12 (01) 73-77
  • 39 Fernandes AS, Costa A, Mota R, Paiva V. Bleomycin sclerotherapy for severe symptomatic and persistent pelvic lymphocele. Case Rep Obstet Gynecol 2014; 2014: 624803
  • 40 Cohan RH, Saeed M, Schwab SJ, Perlmutt LM, Dunnick NR. Povidone-iodine sclerosis of pelvic lymphoceles: a prospective study. Urol Radiol 1988; 10 (04) 203-206
  • 41 Ge W, Yu DC, Chen J. , et al. Lymphocele: a clinical analysis of 19 cases. Int J Clin Exp Med 2015; 8 (05) 7342-7350
  • 42 Hamilton BE, Nesbit GM, Gross N, Andersen P, Sauer D, Harnsberger HR. Characteristic imaging findings in lymphoceles of the head and neck. AJR Am J Roentgenol 2011; 197 (06) 1431-1435
  • 43 Nadolski G. Nontraumatic chylothorax: diagnostic algorithm and treatment options. Tech Vasc Interv Radiol 2016; 19 (04) 286-290
  • 44 Dori Y, Keller MS, Rychik J, Itkin M. Successful treatment of plastic bronchitis by selective lymphatic embolization in a Fontan patient. Pediatrics 2014; 134 (02) e590-e595
  • 45 Gray M, Kovatis KZ, Stuart T. , et al. Treatment of congenital pulmonary lymphangiectasia using ethiodized oil lymphangiography. J Perinatol 2014; 34 (09) 720-722
  • 46 Itkin M. Interventional treatment of pulmonary lymphatic anomalies. Tech Vasc Interv Radiol 2016; 19 (04) 299-304
  • 47 Dori Y, Keller MS, Rome JJ. , et al. Percutaneous lymphatic embolization of abnormal pulmonary lymphatic flow as treatment of plastic bronchitis in patients with congenital heart disease. Circulation 2016; 133 (12) 1160-1170
  • 48 Itkin MG, McCormack FX, Dori Y. Diagnosis and treatment of lymphatic plastic bronchitis in adults using advanced lymphatic imaging and percutaneous embolization. Ann Am Thorac Soc 2016; 13 (10) 1689-1696
  • 49 Acord M, Srinivasan AS, Cahill AM. Percutaneous treatment of lymphatic malformations. Tech Vasc Interv Radiol 2016; 19 (04) 305-311
  • 50 Shah GH, Deshpande MD. Lymphatic malformation in adult patient: a rare case. J Maxillofac Oral Surg 2010; 9 (03) 284-288
  • 51 Breugem CC, van Der Horst CM, Hennekam RC. Progress toward understanding vascular malformations. Plast Reconstr Surg 2001; 107 (06) 1509-1523
  • 52 Itkin M. Magnetic resonance lymphangiography and lymphatic embolization in the treatment of pulmonary complication of lymphatic malformation. Semin Intervent Radiol 2017; 34 (03) 294-300