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CC BY-NC-ND 4.0 · J Neuroanaesth Crit Care 2020; 7(01): S5
DOI: 10.1055/s-0040-1709579
Abstracts

Comparison of Effect of Ketofol (Ketamine and Propofol) versus Propofol on Jugular Venous Oxygen Saturation in Moderate to Severe Traumatic Brain Injury: A Prospective Randomized Trial

Authors

  • Tania Singh

    1   Department of Anaesthesia and Intensive care, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

  • Nidhi Panda

    1   Department of Anaesthesia and Intensive care, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

  • Ankur Luthra

    1   Department of Anaesthesia and Intensive care, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

  • Rajeev Chauhan

    1   Department of Anaesthesia and Intensive care, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
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    Background: Comparison of effect of ketofol with respect to propofol on jugular venous oxygen saturation when used for maintenance of general anesthesia in moderate to severe traumatic brain injury patients as the primary outcome.

    Materials and Methods: A prospective randomized controlled trial was done on 40 TBI patients undergoing decompressive hemicraniectomy. Patients in group P (n = 20) received propofol, while patients in group KP (n = 20) received combination of ketamine and propofol (1:5) for maintenance of anesthesia. SjvO2 monitoring, intraoperative hemodynamic parameters, ONSD, brain relaxation score, S100B levels, MRS at discharge, and extended Glasgow outcome scale (GOSE) at 1 and 3 months were observed.

    Results: No statistically significant difference was found with respect to jugular venous oxygen saturation in either group. However, intraoperative hemodynamic parameters were better maintained in patients receiving ketofol compared with those receiving propofol (p < 0.05) with decreased requirement of phenylephrine or mephentermine in ketofol group. There was no statistically significant difference in quality of brain relaxation, preoperative and postoperative ONSD, MRS, GOSE at 1 month and 3 months, SB100 levels, and number of ventilator days in the either group.

    Conclusions: Ketofol (combination of ketamine and propofol in the ratio 1:5) and propofol similarly maintain cerebral oxygenation. However, hemodynamics appears to be better maintained with ketofol as the maintenance agent.


     

    Publication History

    Article published online:
    25 March 2020

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