Keywords
tinnitus - auditory abilities - auditory perception
Introduction
Tinnitus is the perception of a sound in the ears or in the head, in the absence of
an external stimulus.[1] It is a symptom that can reflect on the functioning of the organism of an individual
as a whole, and can be caused by numerous affections including otological, metabolic,
neurological, orthopedic, cardiovascular, pharmacological, odontological, and/or psychological,
which, in turn, may be present concomitantly in the same individual.[2]
[3]
Tinnitus consists of a symptom that is present in 15% of the general population, and
its incidence increases to 33% in the elderly.[4] Approximately 40% of tinnitus patients also suffer from hyperacusis, which consists
of a decreased tolerance to sounds at intensities considered comfortable to most people.[5] In many cases, tinnitus may cause a great deal of discomfort. Given its difficulty
in characterization and treatment, and according to its severity, tinnitus becomes
a negative repercussion factor in the life of the individual, hampering their sleep,
concentration, daily and professional activities, social life and, often, altering
their emotional balance.[6]
Tinnitus may occur in patients with normal hearing or who exhibit hearing loss.[7] Even with normal hearing thresholds, almost half of the individuals affected by
tinnitus complain of reduced ability to communicate and discriminate words.[8] Studies with patients with hearing loss[9] and with patients with normal hearing[10]
[11] have verified that tinnitus interferes in auditory processing and speech perception
in a noisy environment for some hearing abilities, regardless of the contextual clues
that are provided during the dialogue, therefore affecting the communication of the
individual. Communication losses due to tinnitus can make people irritated, anxious,
distressed, depressed, and insomniac, hampering their quality of life.[12]
[13]
Due to its complex, multiple, and not yet well-understood pathophysiology, several
therapeutic modalities have been employed in the attempt to cure or even relieve and
reduce the perception of tinnitus and hyperacusis. One of the strategies consists
of tinnitus habituation therapy,[14] a treatment based on the neurophysiological model of tinnitus, described by Jastreboff
in 1990.[15] In this model, the disorder is considered the result of a dynamic interaction between
some centers of the central nervous system, including auditory and nonauditory pathways.
One of these interactions occurs between the limbic and the autonomic nervous systems,
generating negative sensations, such as nuisance and stress, which inhibit the habituation
of this symptom.[16] Habituation is defined as a physiological process characterized by the progressive
decline of responses to repetitive stimuli and only occurs if the stimulus is neutral,
that is, free from associations with negative emotional states.[17]
In order for the complete process of tinnitus habituation to occur, two fundamental
principles should be equally valued: counseling and sound therapy.[18] The objective of counseling is to remove adverse associations of tinnitus and demystify
negative beliefs related to the symptom.[17] It consists of an explanation of the anatomy and physiology of central and peripheral
hearing, and its relationship with tinnitus, in addition to recommendations. In turn,
sound therapy aims at facilitating the habituation of tinnitus perception for symptom
relief by reducing the difference between tinnitus-related and background neuronal
activity.[18] The habituation-based treatment of tinnitus produces changes in the neural connections
of the auditory system and may require some time to take place. Some patients become
accustomed quickly, although, by definition, the complete process can occur in up
to 18 months.[18] The benefits of this method of treatment for tinnitus are well-described in the
literature, and several studies have highlighted the reduction of tinnitus loudness
in patients with this symptom, as well as the reduction of the impact of tinnitus
on the quality of life of the patients.[15]
[18]
[19]
Nevertheless, although the efficacy of tinnitus habituation therapy and the possible
influence of this symptom on auditory processing skills are well-understood, studies
that assess whether or not tinnitus improvement through this form of treatment influences
auditory processing are not yet explored. Thus, the objective of the present study
was to verify the effect of tinnitus habituation therapy on the auditory skills, assessed
through behavioral auditory processing tests, self-perception of tinnitus in relation
to loudness, discomfort, and the impact of tinnitus on the quality of life of individuals
with this symptom.
Methods
The present research comprised a quasi-experimental study that was conducted at a
Research Laboratory at Federal University of Minas Gerais, in the city of Belo Horizonte,
Brazil. The study was previously approved by the Ethics and Research Committee under
the number 48473215.9.0000.5149. The participants were referred to the Research Laboratory
by the Auditory Health Care Service. All of the individuals presented with tinnitus
and were evaluated by an otorhinolaryngologist, who referred the patients to the Vestibular
Rehabilitation and Tinnitus Ambulatory of the university hospital in order to carry
out tinnitus habituation therapy.
The inclusion criteria comprised individuals > 18 years old with tinnitus causing
an impact on their quality of life, and who were referred by an otorhinolaryngologist
for tinnitus habituation therapy. The exclusion criteria included patients with significant
hearing loss (> 50 dBHL), given this characteristic hampered the behavioral assessment
of auditory processing since the use of hearing aids (HAs) in these individuals was
necessary; patients who already used HAs; patients who exhibited significant emotional
or cognitive conditions (generalized anxiety, panic disorder, dementia, self-reported
or evident depression, or schizophrenia); participants that presented type As, B,
C or Ad tympanometric curves, which encumber the performance of auditory processing
evaluations, and individuals who did not seem uncomfortable with tinnitus. The subjects
who agreed to participate in the study were required to sign an informed consent term
(ICT).
A total of 41 patients were included in the study, of which 3 dropped out of the treatment,
4 chose not to continue, 1 exhibited an Ad-type tympanometric curve and 1 had a type
C tympanometric curve, 5 displayed self-reported emotional or cognitive disturbances,
5 already used HAs, 2 did not report discomfort with tinnitus, and 1 had severe hearing
loss, and were, therefore, excluded from the study. Thus, the final sample consisted
of 19 individuals.
Initially, all of the subjects were asked to attend an initial counseling group session,
and they were explained the pathophysiology of tinnitus and the objectives of the
research. At this stage, the patients were invited to participate in the study, and
those who agreed signed the ICT. The tests were scheduled and performed at the research
laboratory facility.
All of the patients were initially submitted to anamnesis, tinnitus handicap inventory
(THI) questionnaire, visual analog scale (VAS), otoscopy, and audiological, tinnitus,
and auditory processing evaluations. These procedures were divided into two sessions,
each lasting ∼ 1 hour, to avoid fatigue, drowsiness, and discomfort of the participant.
In the anamnesis, the participants were asked about tinnitus issues such as tinnitus
type, location, associated pains, eating habits, current comorbidities, medications
in use and already used for the symptom, and family history of tinnitus, hearing loss,
and diabetes.
The THI questionnaire was applied to verify the impact of tinnitus on the quality
of life of the individuals. It comprises 25 questions that assess the functional,
emotional and catastrophic aspects of tinnitus. The patient should answer the questions
with “yes,” “sometimes,” and “no,” which scored four, two, and zero points, respectively.
Thus, the maximum score in this questionnaire was 100, and the higher the score, the
greater the impact of tinnitus on the individual's quality of life.
The visual analog scale (VAS) was used to verify the degree of annoyance of the patient
because of tinnitus. The individuals were instructed to visualize the scale and then
assign a score from 0 to 10 regarding the annoyance generated by tinnitus, 10 being
unbearable, and 0 meaning no nuisance brought on by tinnitus.
Meatoscopy was performed to verify if the conditions of the external auditory meatus
were adequate to carry out the hearing tests. The audiological evaluation was conducted
in an acoustically treated environment, according to ISO 8253–120,[20] using the model Astera 2 Otometrics audiometer (Natus, Taastrup, Denmark), the Sennheiser
HDA 200 headset (Sennheiser, Wedemark, Germany), and the B-71 bone vibrator (RadioEar,
Middelfart, Denmark). The exam consisted of conventional and high-frequency audiometry,
with air (frequencies from 250 to 20,000 Hz) and bone auditory thresholds (frequencies
between 500 and 4,000 Hz), and speech audiometry using recorded material (speech recognition
threshold [SRT] and the speech recognition index [SRI]). The audiometric classification
followed the criteria proposed by Biap[22] which considers the average air thresholds at frequencies of 500, 1,000, 2,000,
and 4,000 Hz.
Immitance measures consisted of tympanometry and contralateral acoustic reflexes at
frequencies of 500, 1,000, 2,000, and 4,000 Hz. The tests were performed on the Interacoustics
immitanciometer, model AT235 (Interacoustics, Middelfart, Denmark), and the tympanometry
classification followed the criteria proposed by Jerger.[22] The purpose of this stage was to evaluate the functional integrity of middle ear
structures, since alterations in these structures may influence the auditory processing
evaluation results.
The tinnitus assessment was composed of acuphenometry and the loudness discomfort
levels (LDLs). Acuphenometry consists of a subjective evaluation performed using an
audiometer, in which the participant is subject to several sound stimuli in order
for comparison with the tinnitus reported by the patient, thus characterizing the
symptom regarding its pitch and loudness. To evaluate the frequency, pure tones or
narrowband noises were presented, depending on the characterization reported by the
patient, at frequencies of 250 Hz to 20,000 Hz, 10.0 dBHL above the audiometric threshold.
In turn, to measure the loudness sensation, the signal was increased in steps of 1 dB
on the determined frequency, and patients were instructed to raise their hand when
the signal was at an equivalent loudness to that of the tinnitus. This evaluation
was performed in the contralateral ear to the one exhibiting tinnitus, or in the ear
in which the patient reported the least annoyance.[22] The LDLs were determined at frequencies of 500 to 4,000 Hz using pure tones, and
the intensity of stimulus presentation was increased in steps of 1 dB. Patients were
instructed to raise their hands when they felt discomfort in relation to the sound.
The hyperacusis classification was in accordance with the criteria proposed by Goldstein
et al,[23] and is described in [Table 1].
Table 1
Hyperacusis classification according to Goldstein et al[23]
|
Hyperacusis
|
Discomfort Threshold
|
|
Negative
|
95 db or > at all frequencies
|
|
Mild
|
80–90 db at two or more frequencies
|
|
Moderate
|
65–75 at two or more frequencies
|
|
Severe
|
60 db or < at two or more frequencies
|
To perform the behavioral evaluation of auditory processing, tests were chosen to
assess each auditory ability. Therefore, a low-redundancy monoaural speech test (noisy
speech [NS]), dichotic hearing test (staggered spondaic word test [SSW]), temporal
processing tests (pitch pattern sequence [PPS] and gaps in noise [GIN]), and a binaural
interaction test (masking level difference [MLD]) were performed. The behavioral tests
were also performed in an acoustic booth, using the Itera II Otometrics two-channel
audiometer (Natus, Taastrup, Denmark), coupled with a media player and TDH-39 headphones
(Telephonics, Farmingdale, United States). [Table 2] shows the tests that were employed in the behavioral evaluation of auditory processing,
as well as the assessed hearing abilities in each one, in addition to the applied
performance parameters.
Table 2
Auditory processing tests, evaluated abilities, and performance parameters
|
Test
|
Hearing Abilities
|
Performance Parameters
|
|
NS
|
Auditory Closing
|
Monoaural presentation at 40 dBSL of 25 monosyllables with ipsilateral white noise
at a S/R ratio = + 5
|
|
SSW
|
Figure-background for verbal sounds
Binaural integration
Binaural separation
|
Dichotic presentation at 50 dBSL of four alternate disyllables.
|
|
PPS
|
Temporal ordination
|
Monoaural presentation at 50 dBSL of three pure tones in sequence for the patient
to designate as delicate/heavy (sharp/bass).
|
|
GIN
|
Temporal resolution
|
Monoaural presentation at 50 dBSL for the detection of silence intervals in the noise.
|
|
MLD
|
Binaural interaction
|
Binaural presentation at 50 dBSL of noise and pulsatile tones of 500 Hz, in and out
of phase.
|
Abbreviations: dBSL, sensation level decibels; GIN, gap in noise; Hz, hertz; MLD,
masking level difference; NS, noisy speech; PPS, pitch pattern sequence; S/R, signal/noise
ratio; SSW, staggered spondaic word test.
After completion of the test, the patients were invited to attend a second lecture
aimed at guiding them regarding the lifestyle changes that can help reducing the discomfort
of tinnitus, as well as to explain about tinnitus habituation therapy and its possible
benefits. After the talk, the patients received an MP3 player containing songs of
environmental and instrumental sounds to provide sound therapy, were guided on the
use and handling of the device, and told to use it for at least 3 hours daily, at
the moment in which the tinnitus annoyed them most. In addition, patients received
a control chart to follow the time of daily use of the MP3 player. They were instructed
to mark an “X” in the square corresponding to the daily use period of the device,
in which the options were “up to 1 hour,” “1 to 3 hours,” and “more than 3 hours.”
Then, the patients underwent tinnitus therapy for a period of 6 months, and 3 appointments
were conducted during this time. The 1st and 2nd meetings were performed in the 1st and 3rd months of therapy, respectively, and aimed at reestablishing the given guidelines,
motivating the patient to keep the treatment, and to follow-up on their evolution
and clarify concerns or misconceptions. The third meeting was performed at the end
of the 6th month of therapy, in which the patients were again submitted to acuphenometry, LDLs,
all of the behavioral auditory processing tests, and THI and VAS.
All of the data were recorded in specific forms and later released in Excel 2013 (Microsoft
Corporation, Redmond, WA, USA) program worksheets for results analysis. Descriptive
statistics and statistical analyses were performed using the Student T, T-Paired,
and Wilcoxon tests for numerical variables, and the Shapiro-Wilk and chi-squared tests
for categorical variables, with a significance level of 5% (p < 0.05) and confidence intervals (CIs) of 95% in all of the analyses.
Results
The study sample consisted of 19 individuals, of which 11 were female, and 8 were
male. The mean age was 59 years old (±9.6), ranging from 40 to 74 years old. The data
regarding the tinnitus characteristics of the participants are shown in [Table 3]. In the sample, 57.9% of the subjects stated that they were uncomfortable with intense
sounds, and 42.1% were not bothered by them. Regarding dizziness, 42.1% reported the
presence of the symptom, while 57.9% reported it had never occurred.
Table 3
Data regarding the tinnitus characteristics of the participants
|
Tinnitus characteristics
|
n
|
%
|
|
Sound description
|
Cricket
|
7
|
36.8
|
|
Wheezing/Creaking
|
7
|
36.8
|
|
Pressure Pot
|
2
|
10.5
|
|
Cicada
|
1
|
5.3
|
|
Bee
|
1
|
5.3
|
|
Drops
|
1
|
5.3
|
|
Localization
|
RE
|
4
|
21.1
|
|
LE
|
1
|
5.3
|
|
RE > LE
|
4
|
21.1
|
|
LE > RE
|
4
|
21.1
|
|
RE = LE
|
4
|
21.1
|
|
Head
|
2
|
10.5
|
|
Duration of tinnitus
|
Constant
|
16
|
84.2
|
|
Variable
|
2
|
15.8
|
|
Loudness
|
Mild
|
5
|
26.3
|
|
Moderate
|
9
|
47.4
|
|
Intense
|
2
|
10.5
|
|
Variable
|
3
|
15.8
|
|
Occurrence
|
Sporadic
|
2
|
10.5
|
|
Frequent
|
4
|
21.1
|
|
Very frequent
|
13
|
68.4
|
|
Onset
|
Sudden
|
9
|
47.4
|
|
Progressive
|
10
|
52.6
|
Abbreviations: %, percentage; LE, left ear; n, number of individuals; RE, right ear.
The individuals were also asked if they had frequent pains, such as otalgia, headaches,
neck pain, and in the temporomandibular joint (TMJ). The most frequent pain was headache,
reported by 41.2% of the sample ([Table 4]). Regarding eating habits, 73.7% of the participants reported consuming from 4 to
6 meals per day, and the others stated having 1 to 3 meals a day. A total of 47.4%
stated they ingested high doses of caffeine daily and 57.9% informed sweet food consumption
abuse. As for previous disease history, head trauma, high blood pressure, migraines,
cardiac disorders, diabetes, and high cholesterol levels were reported ([Table 5]).
Table 4
Data regarding the presence of frequent pain in the sample
|
Frequent pain
|
N
|
%
|
|
Headache
Neck pain
TMJ
Otalgia
|
8
5
3
1
|
42.1
26.3
15.8
5.3
|
Abbreviations: TMJ, temporomandibular joint; N, number of individuals; %, percentage.
Table 5
Data regarding the past disease history in the sample
|
Diseases
|
N
|
%
|
|
High blood pressure
Migraines
Diabetes
Heart disorders
Cranial trauma
High cholesterol
|
5
4
3
2
1
1
|
26.3
21.1
15.8
10.6
5.3
5.3
|
Abbreviations: N, number of individuals; %, percentage.
Regarding the drugs used during the study, 47.4% of the patients reported not using
any medication, 31.6% stated using between 1 and 3 substances, and 21.1% informed
the use of > 3 medications. Specific drugs for tinnitus relief were used prior to
the study by 26.3% of the subjects.
As for the family illness history of the participants, 21.1% reported having family
members with hearing loss, 31.6% had relatives with tinnitus, and 42.1% with diabetes.
Considering the criteria adopted for auditory loss classification, more than half
of the participants exhibited hearing within the normal standards, as observed in
[Fig. 1].
Fig. 1 Auditory classification of the participants. Abbreviations: HN: Hearing within the
normality standards; MSHL: Mild sensorineural hearing loss; MoSHL: Moderate sensorineural
hearing loss.
Regarding the established exclusion criteria, all of the participants presented a
type A tympanogram, according to the classification of Jerger.[21] Regarding the stapedial reflexes, more than half of the patients (52.6%) did not
exhibit reflexes in both ears.
In acuphenometry, regarding frequency, 78.9% of the patients reported the presence
of tinnitus at high frequencies, such as 6,000 Hz, and only 21.1% of the subjects
stated perceiving tinnitus at low frequencies (250 and 500 Hz). This result was maintained
after 6 months of therapy, in the reassessment session. Regarding tinnitus loudness,
a comparison between pre- and post-treatment values was conducted using the chi-squared
test, and a statistically significant difference was observed ([Table 6]).
Table 6
Comparisons between the tinnitus loudness values obtained in pre- and post-treatment
Acuphenometry
|
Loudness (dBNS)
|
Minimum
|
Maximum
|
Average
|
Standard deviation
|
p-value
|
|
Initial
Final
|
1
1
|
12
10
|
7.16
4.26
|
3.35
2.46
|
0.001∗
|
Abbreviations: N, number of individuals; %, percentage; p-value, p significance value (Chi-square test).
A Shapiro-Wilk test was also performed to verify the relationship between the initial
and final tinnitus loudness in acuphenometry and the amount of medications used by
the participants. A statistically significant difference was observed in the group
that used 1 to 3 drugs in the final acuphenometry (p = 0.037), exhibiting a smaller reduction in tinnitus loudness.
Regarding hearing hypersensitivity, participants were classified based on the values
obtained in the LDLs, according to the criteria proposed by Goldstein et al.[23] Eleven of the 19 participants reported discomfort with intense sounds during anamnesis.
Ten exhibited auditory hypersensitivity in the right ear, and twelve in the left ear,
determined by LDLs examination.
The comparison between pre- and post-treatment LDLs values in the sample was performed
using the chi-squared test, and statistically significant differences were not observed.
Data regarding the comparisons between initial and final LDLs are shown in [Table 7]. Considering the various tests applied in the pre- and post-treatment evaluations,
the results are shown in [Table 8].
Table 7
Comparisons between the pre- and post-treatment discomfort thresholds, per ear
|
Discomfort Threshold
|
N
|
%
|
p-value
|
|
Initial RE
|
Negative
Mild
Moderate
Severe
|
6
6
3
4
|
31.6
31.6
15.8
21.1
|
0.416
|
|
Final RE
|
Negative
Mild
Moderate
Severe
|
9
6
3
1
|
47.4
31.6
15.8
5.3
|
|
|
Initial LE
|
Negative
Mild
Moderate
Severe
|
7
5
3
4
|
36.8
26.3
15.8
21.1
|
0.287
|
|
Final LE
|
Negative
Mild
Moderate
Severe
|
11
2
5
1
|
57.9
10.5
26.3
5.3
|
|
Abbreviations: N, number of individuals; %, percentage; p-value, p significance value (Chi-square test); RE, right ear; LE, left ear.
Table 8
Comparison between the results obtained in the different pre- and post-treatment assessments
|
Assessments
|
|
Minimum
|
Maximum
|
Average
|
Standard deviation
|
p-value
|
|
CAP
|
SSW CR
SSW CL
NS RE
NS LE
PPS RE
PPS LE
GIN RE
GIN LE
MLD
|
Initial
Final
Initial
Final
Initial
Final
Initial
Final
Initial
Final
Initial
Final
Initial
Final
Initial
Final
Initial
Final
|
57.5
60.0
18.0
17.5
72.0
80.0
76.0
84.0
30.0
73.3
46.6
73.3
5.0
5.0
5.0
5.0
8.0
8.0
|
100
100
98.0
97.5
100
100
100
100
100
100
100
100
15.0
12.0
12.0
10.0
20.0
18.0
|
83.6
85.7
72.8
76.8
91.3
92.6
91.7
93.8
88.5
90.6
89.7
90.6
7.0
7.3
8.2
8.5
13.5
12.9
|
12.4
11.5
23.3
20.6
7.9
6.5
7.3
5.0
16.7
8.7
13.7
8.4
2.8
2.4
1.8
1.8
3.3
2.8
|
0.243
0.061
0.299
0.082
0.592
0.948
0.418
0.626
0.626
|
|
THI
|
Functional
Emotional
Catastrophic
Total
|
Initial
Final
Initial
Final
Initial
Final
Initial
Final
|
0.0
0.0
0.0
0.0
0.0
0.0
8.0
4.0
|
28.0
20.0
30.0
28.0
14.0
14.0
72.0
54.0
|
12.5
7.6
12.6
8.0
6.9
6.5
32.1
21.6
|
8.3
6.5
8.8
6.9
4.3
3.7
19.5
13.7
|
0.044∗
0.004∗
0.706
0.023∗
|
|
VAS
|
Initial
Final
|
2.0
1.0
|
10.0
8.0
|
6.7
4.9
|
2.4
2.1
|
0.001∗
|
Abbreviations: CAP, central auditory processing; CR, competitive right; CL, competitive
left; RE, right ear; LE, left ear; SSW, staggered spondaic words; NS, noisy speech;
PPS, pitch pattern sequence; GIN, gap in noise; MLD, masking level difference; THI,
tinnitus handicap inventory; VAS, visual analogical scale; p-value, p significance value (Chi-square test).
To verify the influence of hearing loss on the auditory processing tests, a comparison
was conducted using the results obtained in the patients with and without hearing
loss. A statistically significant difference (p = 0.045) was observed only in the SSW test in the right competitive condition. The
other tests did not show statistical differences between individuals with and without
hearing loss.
Discussion
Regarding gender, 57.9% of the participants were female and 42.1% were male, demonstrating
an almost equivalent distribution. The literature is controversial concerning the
influence of gender on the prevalence of tinnitus. Some studies have shown that tinnitus
is more prevalent in males,[24]
[25] while others suggest a predominance in females[26]
[27]. One possible reason for the higher prevalence in males would be the fact that they
are more present in occupational environments with high levels of noise, and, therefore,
are more predisposed to hearing loss and tinnitus.[28] On the other hand, the more considerable occurrence in women may be related to the
fact that they are more careful and concerned regarding their health, seeking medical
assistance more frequently.[29]
The mean age of the sample was 59 years old (±9.6), ranging from 40 to 74 years old.
This average was close to that found in other studies, evidencing a higher prevalence
of tinnitus in individuals around the age of 60 years old.[26]
[27]
[30] It is believed that this finding may be related to possible presbycusis, since it
is generally agreed that tinnitus is related to hearing loss, and presbycusis affects
individuals as of 60 years of age.[31]
[32]
Considering tinnitus characteristics, 73.6% of the participants described the disorder
as a wheezing or cricket sound. The predominance of these findings was also observed
in other studies, corroborating with the present research.[33]
[34] A total of 60% of the participants were bilaterally affected by tinnitus, regardless
of loudness. Approximately 26.4% stated that the symptom was unilateral, and 10.5%
reported occurrence in the head. However, even though in the literature studies also
describe a higher prevalence of bilateral tinnitus,[29]
[30]
[34] there is no consensus regarding its location.[33] Sanches et al suggested that the location of tinnitus could be related to its etiology.[35]
Regarding the duration of tinnitus, 84.2% of the volunteers reported it as constant,
and only 15.8% considered it variable. This finding was also observed in other researches,
thus corroborating with the present study.[30]
[33] Concerning loudness, ∼ 50% of the subjects reported it as moderate, a finding that
was also verified in other studies.[33]
[35] Cruz observed that the symptom appeared abruptly in 80% of the participants.[34] In the present study, the onset of the disorder occurred practically in a similar
way, in which nine patients reported that tinnitus occurred suddenly and progressively.
Nonetheless, although result similarity has been evidenced with that found in other
studies, in relation to the data regarding the duration of tinnitus, loudness, and
the onset of the symptom, it is known that tinnitus is subjective and difficult to
characterize, and, therefore, these factors can vary significantly in each individual.
In our sample, 57.9% of the participants reported discomfort with intense sounds.
According to the literature, ∼ 40% of the individuals who have tinnitus exhibit high
sensitivity to intense sounds. This result can be explained due to the fact that tinnitus
and auditory hypersensitivity have the same pathophysiological basis.[36]
[37] Also, an imaging study stated that peripheral hearing loss can generate poor adaptation
in the central auditory system, and has, as the primary risk factor, tinnitus and
hearing hypersensitivity[38].
Dizziness was observed in 42.1% of the participants. This symptom as well as tinnitus
may be due to changes in the same structure, the inner ear, and, therefore, often
occurring concomitantly.[39] Headaches and neck pain were the main findings related to the frequently reported
pain. Injuries to the neck, middle ear, headaches, and sinusitis increase the risk
of tinnitus from 28 to 35%.[40]
Adequate eating habits are essential to maintaining the proper functioning of the
inner ear, which practically lacks energy reserves. Thus, in addition to nourishment
every 3 hours, it is necessary to lower the consumption of fat and sugar.[41]
[42] Approximately 25% of the individuals stated eating from 1 to 3 meals per day, and
57.9% reported sweet food ingestion abuse, features that may contribute to the worsening
of tinnitus. Therefore, in the present study, food guidelines were given the utmost
importance during all of the appointments with the patients, since, even though the
extent to which this factor interferes in the worsening of tinnitus is yet unknown,
good eating habits may be a determining factor in the improvement of the symptom.
Furthermore, in the present study, special attention was given to caffeine intake,
given it is known to be a central nervous system stimulant and vasoconstrictor, which
may worsen the perception of tinnitus. A study has shown that physicians believe that
50% of the individuals complaining of tinnitus improve their clinical conditions with
reduced caffeine intake.[43]
Regarding previous disease history, head traumas, cardiac disorders, diabetes and
high cholesterol, high blood pressure, and migraines were reported; the latter two
retaining the highest occurrences in the sample. The possibility of occurrence of
these various factors and the probable interaction between them encumbers determining
the cause of tinnitus.[43]
Regarding medication use, 52.7% of the individuals took some type of drug, and 26.3%
reported having used tinnitus relief medication. A recent study stated that pharmacotherapy
can trigger or aggravate vestibular symptoms such as vertigo, tinnitus, and dizziness
in the elderly, and attention and caution are therefore required in medication prescription
in this population.[44]
It was observed that 21.1% of the participants reported family histories of hearing
loss, 31.6% of tinnitus, and 42.1% of diabetes. This result corroborates a study from
the literature that states that 54.7% of the subjects with tinnitus complaints have
family members with hearing loss, tinnitus or diabetes.[43]
The vast majority of studies with tinnitus patients considered hearing within the
normal range when the air thresholds at frequencies between 500 and 8,000 Hz are < 25 dBHL.[10]
[11]
[45] However, in these individuals, it is believed that a significant lesion is present
in the external hair cells at frequencies > 8,000 Hz, which may justify the presence
of tinnitus. This lesion is detected by high-frequency audiometry, although few establishments
have this equipment and, therefore, the evaluation is not conducted.[46]
[47]
[48] Nevertheless, it is known that hearing loss triggers the occurrence of tinnitus[49] and, regardless of whether it occurs at the apex or the base of the cochlea, it
is believed that individuals who complain of tinnitus have lesions of external hair
cells in a specific region of the organ. In the present study, the audiometries were
classified according to the Biap[21] criteria, which considers a greater number of frequencies in the average, from 500
to 4,000 Hz. Thus, ∼ 60% of the sample was composed of subjects who exhibited hearing
within the normal standards, bilaterally, which does not corroborate with the findings
in the literature due to the previously mentioned reasons.
In acuphenometry, 78.9% of the volunteers exhibited tinnitus at high frequencies,
as of 6,000 Hz. The same result was described in a study that analyzed the frequency
and loudness of tinnitus in individuals with presbycusis. However, significant associations
between the frequency range of the highest auditory threshold and the frequency of
tinnitus were not observed.[50] Regarding tinnitus loudness, a statistically significant difference was observed
in the pre- and postintervention evaluation (p = 0.001), evidencing the efficacy of tinnitus habituation therapy in reducing tinnitus
loudness.
The existence of a relationship between the loudness of the initial and final tinnitus
in acuphenometry and the use of medication was also verified. A statistically significant
difference was observed in the group of patients who used 1 to 3 drugs in the final
loudness (p = 0.037). Of the 6 patients that were part of this group, 50% exhibited a decrease
in tinnitus loudness, and among the others that did not show improvement, 2 maintained
the final loudness value and 1 obtained a worsening of 1.0 dB. It is worth mentioning
that the latter had already used medication for tinnitus relief. The pharmacological
groups that these patients were exposed to were not described, although it is believed
that the use of drugs can contribute to generating resistance in reducing the loudness
of tinnitus.[44]
Regarding auditory hypersensitivity, the values of the pre- and post-treatment discomfort
threshold were compared, and a statistically significant difference was not observed
in both ears (p = 0.416 and 0.287 in the right and left ears, respectively). However, there was an
increase in the number of participants who had negative discomfort thresholds in both
ears, that is, they did not exhibit auditory hypersensitivity after treatment. We
believe that statistical significance was not achieved due to the small size of the
sample. Nonetheless, a post-treatment trend of reduction in the number of patients
classified as displaying severe discomfort thresholds was observed, in addition to
an increase in the number of individuals with negative discomfort thresholds, indicating
a decrease in the absolute number of individuals with auditory hypersensitivity.
Regarding the auditory processing evaluation, a statistically significant difference
was not observed in the pre- and post-treatment evaluation. Although the reduction
in the perception of the individual on the loudness and annoyance of tinnitus was
verified, as well as the improvement of the impact of this symptom on the quality
of life of the participant, the influence of these factors in the development of auditory
processing abilities was not observed. The comparison of the auditory processing test
results among normal hearing patients and those with hearing loss showed a statistically
significant influence (p = 0.045) regarding the SSW test in the right competitive condition. This condition
is known to be directly related to changes in the left hemisphere, which is dominant
for language. Therefore, even mild hearing loss may influence the linguistic aspects
of the patient.[51]
In the comparison between the initial and final THI, a statistically significant difference
was observed regarding the functional, emotional, and total aspects. Statistical significance
was not achieved regarding the catastrophic aspect. As for VAS, a statistically significant
difference was also observed in the comparison between the initial and final values.
These results demonstrate a reduction in the impact of tinnitus on the quality of
life of the patient and the discomfort caused by the symptom. It is believed that
guideline emphasis, as well as follow-ups of patients through frequent appointments,
was of fundamental importance in their progress, contributing to the strengthening
of the therapist-patient bond, which consequently generates more confidence in the
proposed treatment, and facilitates patient acceptance in relation to the changes
in attitude required to improve tinnitus.
Finally, due to the small sample size of the present study, we need more data to find
the generalizability of our results. The present study is indeed a preliminary step
to move toward a comprehension on the influence of tinnitus therapy on auditory abilities.
Further investigation in a larger sample of tinnitus patients is therefore warranted,
along with an exploration of the impact tinnitus may have on the auditory processing
skills.
Conclusion
Tinnitus habituation therapy was effective in reducing the perception of tinnitus
loudness and discomfort, as well as the impact of the symptom on the quality of life
of the patient. However, the influence of these factors on the improvement of auditory
processing skills was not observed.
