Synfacts 2020; 16(07): 0795
DOI: 10.1055/s-0040-1707836
Metals in Synthesis
© Georg Thieme Verlag Stuttgart · New York

Dual-Catalyst Photoinduced Alkenylation of Alkanes and Aldehydes via C–H Activation

Paul Knochel
Simon Graßl
Cao H, Kuang Y, Shi X, Wong KL, Tan BB, Kwan JM. C, Liu X, Wu J. * National University of Singapore, Republic of Singapore, and National University of Singapore (Suzhou) Research Institute, Suzhou, P. R. of China
Photoinduced Site-Selective Alkenylation of Alkanes and Aldehydes with Aryl Alkenes.

Nat. Commun. 2020;
DOI: 10.1038/s41467-020-15878-6z.
Further Information

Publication History

Publication Date:
17 June 2020 (online)



The authors report a site-selective photoinduced alkenylation of various alkanes and aldehydes with aryl and heteroaryl alkenes. This dehydrogenative reaction utilizes two photoactive catalysts (tetra-n-butylammonium decatungstate (TBADT) as HAT agent and Co(dmgH)(dmgH2)Cl2), which eliminates the need for an external oxidant.



This mild alkenylation was used for the late-stage functionalization of diverse complex molecules, while still ensuring a high level of site-selectivity for the sterically most accessible and most electron-rich C–H bond. Wu and co-workers propose a mechanism that involves cooperation of the tungstate and the cobalt catalysts.