Dual-Catalyst Photoinduced Alkenylation of Alkanes and Aldehydes via C–H Activation
Photoinduced Site-Selective Alkenylation of Alkanes and Aldehydes with Aryl Alkenes.
Nat. Commun. 2020;
17 June 2020 (online)
The authors report a site-selective photoinduced alkenylation of various alkanes and aldehydes with aryl and heteroaryl alkenes. This dehydrogenative reaction utilizes two photoactive catalysts (tetra-n-butylammonium decatungstate (TBADT) as HAT agent and Co(dmgH)(dmgH2)Cl2), which eliminates the need for an external oxidant.
This mild alkenylation was used for the late-stage functionalization of diverse complex molecules, while still ensuring a high level of site-selectivity for the sterically most accessible and most electron-rich C–H bond. Wu and co-workers propose a mechanism that involves cooperation of the tungstate and the cobalt catalysts.