Tantalum-or Titanium-Catalyzed Peptide Synthesis

Key words

tantalum catalysis - titanium catalysis - substrate-directed reaction

Significance

The development of elegant synthetic methodologies for peptide-bond formation is a highly demanding task in organic synthesis. A substrate-directed, Lewis acid-catalyzed, racemization-free amidation method has been developed to access various peptides.

Comment

The tantalum-catalyzed substrate-directed peptide-bond-formation reaction proceeds with various amino acids under solvent-free conditions and delivers peptides in high yields without racemization. This method further extends titanium-catalyzed oligopeptide synthesis.