Semin Neurol 2020; 40(01): 018-032
DOI: 10.1055/s-0039-3402068
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Vestibular-Evoked Myogenic Potential Testing in Vestibular Localization and Diagnosis

Rachael L. Taylor
1   Department of Physiology, Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Grafton, Auckland, New Zealand
,
Miriam S. Welgampola
2   Department of Neurology, Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
3   Central Clinical School, The University of Sydney, Sydney, NSW, Australia
,
Benjamin Nham
2   Department of Neurology, Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
3   Central Clinical School, The University of Sydney, Sydney, NSW, Australia
,
2   Department of Neurology, Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
3   Central Clinical School, The University of Sydney, Sydney, NSW, Australia
› Author Affiliations
Funding R.L.T. was supported by an Aotearoa Fellowship from the Centre for Brain Research, the University of Auckland, New Zealand.
S.M.R. was supported by a Fellowship from the National Health and Medical Research Council of Australia (GNT1104772).
Further Information

Publication History

Publication Date:
14 January 2020 (online)

Abstract

Vestibular-evoked myogenic potentials (VEMPs) are short-latency, otolith-dependent reflexes recorded from the neck and eye muscles. They are widely used in neuro-otology clinics as tests of otolith function. Cervical VEMPs are recorded from the neck muscles and reflect predominantly saccular function, while ocular VEMPs are reflexes of the extraocular muscles and reflect utricular function. They have an important role in the diagnosis of superior canal dehiscence syndrome and provide complementary information about otolith function that is useful in the diagnosis of other vestibular disorders. Like other evoked potentials, they can provide important localizing information about lesions that may occur along the VEMP pathway. This review will describe the VEMP abnormalities seen in common disorders of the vestibular system and its pathways.

 
  • References

  • 1 Bickford RG, Jacobson JL, Cody DT. Nature of average evoked potentials to sound and other stimuli in man. Ann N Y Acad Sci 1964; 112: 204-223
  • 2 Colebatch JG, Halmagyi GM. Vestibular evoked potentials in human neck muscles before and after unilateral vestibular deafferentation. Neurology 1992; 42 (08) 1635-1636
  • 3 Colebatch JG, Halmagyi GM, Skuse NF. Myogenic potentials generated by a click-evoked vestibulocollic reflex. J Neurol Neurosurg Psychiatry 1994; 57 (02) 190-197
  • 4 Young ED, Fernández C, Goldberg JM. Responses of squirrel monkey vestibular neurons to audio-frequency sound and head vibration. Acta Otolaryngol 1977; 84 (5-6): 352-360
  • 5 McCue MP, Guinan Jr JJ. Acoustically responsive fibers in the vestibular nerve of the cat. J Neurosci 1994; 14 (10) 6058-6070
  • 6 Murofushi T, Curthoys IS, Topple AN, Colebatch JG, Halmagyi GM. Responses of guinea pig primary vestibular neurons to clicks. Exp Brain Res 1995; 103 (01) 174-178
  • 7 Kushiro K, Zakir M, Ogawa Y, Sato H, Uchino Y. Saccular and utricular inputs to sternocleidomastoid motoneurons of decerebrate cats. Exp Brain Res 1999; 126 (03) 410-416
  • 8 Todd NP, Rosengren SM, Colebatch JG. A short latency vestibular evoked potential (VsEP) produced by bone-conducted acoustic stimulation. J Acoust Soc Am 2003; 114 (6 Pt 1): 3264-3272
  • 9 Todd NP, Rosengren SM, Aw ST, Colebatch JG. Ocular vestibular evoked myogenic potentials (OVEMPs) produced by air- and bone-conducted sound. Clin Neurophysiol 2007; 118 (02) 381-390
  • 10 Rosengren SM, McAngus Todd NP, Colebatch JG. Vestibular-evoked extraocular potentials produced by stimulation with bone-conducted sound. Clin Neurophysiol 2005; 116 (08) 1938-1948
  • 11 Iwasaki S, McGarvie LA, Halmagyi GM. , et al. Head taps evoke a crossed vestibulo-ocular reflex. Neurology 2007; 68 (15) 1227-1229
  • 12 Weber KP, Rosengren SM, Michels R, Sturm V, Straumann D, Landau K. Single motor unit activity in human extraocular muscles during the vestibulo-ocular reflex. J Physiol 2012; 590 (13) 3091-3101
  • 13 Iwasaki S, Chihara Y, Smulders YE. , et al. The role of the superior vestibular nerve in generating ocular vestibular-evoked myogenic potentials to bone conducted vibration at Fz. Clin Neurophysiol 2009; 120 (03) 588-593
  • 14 Welgampola MS, Colebatch JG. Characteristics of tone burst-evoked myogenic potentials in the sternocleidomastoid muscles. Otol Neurotol 2001; 22 (06) 796-802
  • 15 Janky KL, Shepard N. Vestibular evoked myogenic potential (VEMP) testing: normative threshold response curves and effects of age. J Am Acad Audiol 2009; 20 (08) 514-522
  • 16 Taylor RL, Bradshaw AP, Halmagyi GM, Welgampola MS. Tuning characteristics of ocular and cervical vestibular evoked myogenic potentials in intact and dehiscent ears. Audiol Neurotol 2012; 17 (04) 207-218
  • 17 Welgampola MS, Colebatch JG. Vestibulocollic reflexes: normal values and the effect of age. Clin Neurophysiol 2001; 112 (11) 1971-1979
  • 18 Rosengren SM, Govender S, Colebatch JG. Ocular and cervical vestibular evoked myogenic potentials produced by air- and bone-conducted stimuli: comparative properties and effects of age. Clin Neurophysiol 2011; 122 (11) 2282-2289
  • 19 Govender S, Fernando T, Dennis DL, Welgampola MS, Colebatch JG. Properties of 500Hz air- and bone-conducted vestibular evoked myogenic potentials (VEMPs) in superior canal dehiscence. Clin Neurophysiol 2016; 127 (06) 2522-2531
  • 20 Murofushi T, Shimizu K, Takegoshi H, Cheng PW. Diagnostic value of prolonged latencies in the vestibular evoked myogenic potential. Arch Otolaryngol Head Neck Surg 2001; 127 (09) 1069-1072
  • 21 Poretti A, Palla A, Tarnutzer AA. , et al. Vestibular impairment in patients with Charcot-Marie-Tooth disease. Neurology 2013; 80 (23) 2099-2105
  • 22 Rosengren SM, Aw ST, Halmagyi GM, Todd NP, Colebatch JG. Ocular vestibular evoked myogenic potentials in superior canal dehiscence. J Neurol Neurosurg Psychiatry 2008; 79 (05) 559-568
  • 23 Janky KL, Nguyen KD, Welgampola M, Zuniga MG, Carey JP. Air-conducted oVEMPs provide the best separation between intact and superior canal dehiscent labyrinths. Otol Neurotol 2013; 34 (01) 127-134
  • 24 Zuniga MG, Janky KL, Nguyen KD, Welgampola MS, Carey JP. Ocular versus cervical VEMPs in the diagnosis of superior semicircular canal dehiscence syndrome. Otol Neurotol 2013; 34 (01) 121-126
  • 25 Verrecchia L, Glad K, Frisk R, Duan M. Vestibular myogenic potentials evoked by air-conducted stimuli at safe acoustic intensity levels retain optimal diagnostic properties for superior canal dehiscence syndrome. Acta Otolaryngol 2019; 139 (01) 11-17
  • 26 Verrecchia L, Brantberg K, Tawfique Z, Maoli D. Diagnostic accuracy of ocular vestibular evoked myogenic potentials for superior canal dehiscence syndrome in a large cohort of dizzy patients. Ear Hear 2019; 40 (02) 287-294
  • 27 Manzari L, Burgess AM, McGarvie LA, Curthoys IS. An indicator of probable semicircular canal dehiscence: ocular vestibular evoked myogenic potentials to high frequencies. Otolaryngol Head Neck Surg 2013; 149 (01) 142-145
  • 28 Brantberg K, Verrecchia L. Testing vestibular-evoked myogenic potentials with 90-dB clicks is effective in the diagnosis of superior canal dehiscence syndrome. Audiol Neurotol 2009; 14 (01) 54-58
  • 29 Verrecchia L, Westin M, Duan M, Brantberg K. Ocular vestibular evoked myogenic potentials to vertex low frequency vibration as a diagnostic test for superior canal dehiscence. Clin Neurophysiol 2016; 127 (04) 2134-2139
  • 30 Taylor RL, Blaivie C, Bom AP. , et al. Ocular vestibular-evoked myogenic potentials (oVEMP) to skull taps in normal and dehiscent ears: mechanisms and markers of superior canal dehiscence. Exp Brain Res 2014; 232 (04) 1073-1084
  • 31 Cloutier JF, Bélair M, Saliba I. Superior semicircular canal dehiscence: positive predictive value of high-resolution CT scanning. Eur Arch Otorhinolaryngol 2008; 265 (12) 1455-1460
  • 32 Crovetto M, Whyte J, Rodriguez OM, Lecumberri I, Martinez C, Eléxpuru J. Anatomo-radiological study of the superior semicircular canal dehiscence radiological considerations of superior and posterior semicircular canals. Eur J Radiol 2010; 76 (02) 167-172
  • 33 Carey JP, Minor LB, Nager GT. Dehiscence or thinning of bone overlying the superior semicircular canal in a temporal bone survey. Arch Otolaryngol Head Neck Surg 2000; 126 (02) 137-147
  • 34 Ward BK, Wenzel A, Ritzl EK. , et al. Near-dehiscence: clinical findings in patients with thin bone over the superior semicircular canal. Otol Neurotol 2013; 34 (08) 1421-1428
  • 35 Ward BK, Carey JP, Minor LB. Superior canal dehiscence syndrome: lessons from the first 20 years. Front Neurol 2017; 8: 177
  • 36 Young YH, Wu CC, Wu CH. Augmentation of vestibular evoked myogenic potentials: an indication for distended saccular hydrops. Laryngoscope 2002; 112 (03) 509-512
  • 37 Lee S-U, Kim H-J, Choi J-Y, Koo J-W, Kim J-S. Abnormal cervical vestibular-evoked myogenic potentials predict evolution of isolated recurrent vertigo into Meniere's disease. Front Neurol 2017; 8: 463-463
  • 38 Taylor RL, Wijewardene AA, Gibson WP, Black DA, Halmagyi GM, Welgampola MS. The vestibular evoked-potential profile of Ménière's disease. Clin Neurophysiol 2011; 122 (06) 1256-1263
  • 39 Zhou YJ, Wu YZ, Cong N. , et al. Contrasting results of tests of peripheral vestibular function in patients with bilateral large vestibular aqueduct syndrome. Clin Neurophysiol 2017; 128 (08) 1513-1518
  • 40 Manzari L. Vestibular signs and symptoms of volumetric abnormalities of the vestibular aqueduct. J Laryngol Otol 2008; 122 (06) 557-563
  • 41 Sheykholeslami K, Schmerber S, Habiby Kermany M, Kaga K. Vestibular-evoked myogenic potentials in three patients with large vestibular aqueduct. Hear Res 2004; 190 (1-2): 161-168
  • 42 Aw ST, Welgampola MS, Bradshaw AP, Todd MJ, Magnussen JS, Halmagyi GM. Click-evoked vestibulo-ocular reflex distinguishes posterior from superior canal dehiscence. Neurology 2010; 75 (10) 933-935
  • 43 Gopen Q, Zhou G, Poe D, Kenna M, Jones D. Posterior semicircular canal dehiscence: first reported case series. Otol Neurotol 2010; 31 (02) 339-344
  • 44 Lopez-Escamez JA, Carey J, Chung WH. , et al; Classification Committee of the Barany Society; Japan Society for Equilibrium Research; European Academy of Otology and Neurotology (EAONO); Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS); Korean Balance Society. Diagnostic criteria for Menière's disease. J Vestib Res 2015; 25 (01) 1-7
  • 45 Okuno T, Sando I. Localization, frequency, and severity of endolymphatic hydrops and the pathology of the labyrinthine membrane in Menière's disease. Ann Otol Rhinol Laryngol 1987; 96 (04) 438-445
  • 46 Egami N, Ushio M, Yamasoba T, Yamaguchi T, Murofushi T, Iwasaki S. The diagnostic value of vestibular evoked myogenic potentials in patients with Meniere's disease. J Vestib Res 2013; 23 (4-5): 249-257
  • 47 Taylor RL, Zagami AS, Gibson WP. , et al. Vestibular evoked myogenic potentials to sound and vibration: characteristics in vestibular migraine that enable separation from Meniere's disease. Cephalalgia 2012; 32 (03) 213-225
  • 48 Rauch SD, Zhou G, Kujawa SG, Guinan JJ, Herrmann BS. Vestibular evoked myogenic potentials show altered tuning in patients with Ménière's disease. Otol Neurotol 2004; 25 (03) 333-338
  • 49 Zuniga MG, Janky KL, Schubert MC, Carey JP. Can vestibular-evoked myogenic potentials help differentiate Ménière disease from vestibular migraine?. Otolaryngol Head Neck Surg 2012; 146 (05) 788-796
  • 50 Inoue A, Egami N, Fujimoto C, Kinoshita M, Yamasoba T, Iwasaki S. Vestibular evoked myogenic potentials in vestibular migraine: do they help differentiating from Menière's disease?. Ann Otol Rhinol Laryngol 2016; 125 (11) 931-937
  • 51 Kim MB, Choi J, Park GY, Cho YS, Hong SH, Chung WH. Clinical value of vestibular evoked myogenic potential in assessing the stage and predicting the hearing results in Ménière's disease. Clin Exp Otorhinolaryngol 2013; 6 (02) 57-62
  • 52 Winters SM, Campschroer T, Grolman W, Klis SF. Ocular vestibular evoked myogenic potentials in response to air-conducted sound in Ménière's disease. Otol Neurotol 2011; 32 (08) 1273-1280
  • 53 Huang CH, Wang SJ, Young YH. Localization and prevalence of hydrops formation in Ménière's disease using a test battery. Audiol Neurotol 2011; 16 (01) 41-48
  • 54 Chen L, Xu H, Wang WQ, Zhang QQ, Lv QY, Song XC. Evaluation of the otolith function using c/oVEMPs in patients with Ménière's disease. J Otolaryngol Head Neck Surg 2016; 45 (01) 39
  • 55 Young YH, Huang TW, Cheng PW. Assessing the stage of Meniere's disease using vestibular evoked myogenic potentials. Arch Otolaryngol Head Neck Surg 2003; 129 (08) 815-818
  • 56 Manzari L, Tedesco AR, Burgess AM, Curthoys IS. Ocular and cervical vestibular-evoked myogenic potentials to bone conducted vibration in Ménière's disease during quiescence vs during acute attacks. Clin Neurophysiol 2010; 121 (07) 1092-1101
  • 57 Sandhu JS, Low R, Rea PA, Saunders NC. Altered frequency dynamics of cervical and ocular vestibular evoked myogenic potentials in patients with Ménière's disease. Otol Neurotol 2012; 33 (03) 444-449
  • 58 Zhu Y, McPherson J, Beatty C. , et al. Cervical VEMP threshold response curve in the identification of Ménière's disease. J Am Acad Audiol 2014; 25 (03) 278-288 , quiz 302–303
  • 59 Jerin C, Berman A, Krause E, Ertl-Wagner B, Gürkov R. Ocular vestibular evoked myogenic potential frequency tuning in certain Menière's disease. Hear Res 2014; 310: 54-59
  • 60 Murofushi T, Ozeki H, Inoue A, Sakata A. Does migraine-associated vertigo share a common pathophysiology with Meniere's disease? Study with vestibular-evoked myogenic potential. Cephalalgia 2009; 29 (12) 1259-1266
  • 61 Maxwell R, Jerin C, Gürkov R. The effect of elevated intracranial pressure on frequency tuning of air-conducted ocular vestibular myogenic potentials in Ménière's disease patients. Otol Neurotol 2017; 38 (06) 916-920
  • 62 Murofushi T, Tsubota M, Suizu R, Yoshimura E. Cervical vestibular evoked myogenic potential tuning properties of patients with recurrent peripheral vestibulopathy: is it Meniere's disease without hearing loss?. Clin Neurophysiol 2017; 128 (12) 2491-2492
  • 63 Seo T, Shiraishi K, Kobayashi T. , et al. Revision of a furosemide-loading vestibular-evoked myogenic potential protocol for detecting endolymphatic hydrops. Acta Otolaryngol 2017; 137 (12) 1244-1248
  • 64 Seo T, Saka N, Sakagami M. Furosemide-loading vestibular evoked myogenic potential testing can suggest developing bilateral involvement of unilateral Meniere's disease. Acta Otolaryngol 2012; 132 (06) 632-636
  • 65 Seo T, Node M, Yukimasa A, Sakagami M. Furosemide loading vestibular evoked myogenic potential for unilateral Ménière's disease. Otol Neurotol 2003; 24 (02) 283-288
  • 66 Murofushi T, Matsuzaki M, Takegoshi H. Glycerol affects vestibular evoked myogenic potentials in Meniere's disease. Auris Nasus Larynx 2001; 28 (03) 205-208
  • 67 Murofushi T, Komiyama S, Suizu R. Detection of saccular endolymphatic hydrops in Ménière's disease using a modified glycerol cVEMP test in combination with the tuning property test. Otol Neurotol 2016; 37 (08) 1131-1136
  • 68 Nakashima T, Naganawa S, Sugiura M. , et al. Visualization of endolymphatic hydrops in patients with Meniere's disease. Laryngoscope 2007; 117 (03) 415-420
  • 69 Katayama N, Yamamoto M, Teranishi M. , et al. Relationship between endolymphatic hydrops and vestibular-evoked myogenic potential. Acta Otolaryngol 2010; 130 (08) 917-923
  • 70 Gürkov R, Flatz W, Louza J, Strupp M, Ertl-Wagner B, Krause E. In vivo visualized endolymphatic hydrops and inner ear functions in patients with electrocochleographically confirmed Ménière's disease. Otol Neurotol 2012; 33 (06) 1040-1045
  • 71 Guo P, Sun W, Shi S, Zhang F, Wang J, Wang W. Quantitative evaluation of endolymphatic hydrops with MRI through intravenous gadolinium administration and VEMP in unilateral definite Meniere's disease. Eur Arch Otorhinolaryngol 2019; 276 (04) 993-1000
  • 72 Seo YJ, Kim J, Choi JY, Lee WS. Visualization of endolymphatic hydrops and correlation with audio-vestibular functional testing in patients with definite Meniere's disease. Auris Nasus Larynx 2013; 40 (02) 167-172
  • 73 Kim EJ, Oh SY, Kim JS, Yang TH, Yang SY. Persistent otolith dysfunction even after successful repositioning in benign paroxysmal positional vertigo. J Neurol Sci 2015; 358 (1-2): 287-293
  • 74 Singh NK, Apeksha K. Efficacy of cervical and ocular vestibular-evoked myogenic potentials in evaluation of benign paroxysmal positional vertigo of posterior semicircular canal. Eur Arch Otorhinolaryngol 2016; 273 (09) 2523-2532
  • 75 Nakahara H, Yoshimura E, Tsuda Y, Murofushi T. Damaged utricular function clarified by oVEMP in patients with benign paroxysmal positional vertigo. Acta Otolaryngol 2013; 133 (02) 144-149
  • 76 Lee JD, Park MK, Lee BD, Lee TK, Sung KB, Park JY. Abnormality of cervical vestibular-evoked myogenic potentials and ocular vestibular-evoked myogenic potentials in patients with recurrent benign paroxysmal positional vertigo. Acta Otolaryngol 2013; 133 (02) 150-153
  • 77 Yang WS, Kim SH, Lee JD, Lee WS. Clinical significance of vestibular evoked myogenic potentials in benign paroxysmal positional vertigo. Otol Neurotol 2008; 29 (08) 1162-1166
  • 78 Murofushi T, Halmagyi GM, Yavor RA, Colebatch JG. Absent vestibular evoked myogenic potentials in vestibular neurolabyrinthitis. An indicator of inferior vestibular nerve involvement?. Arch Otolaryngol Head Neck Surg 1996; 122 (08) 845-848
  • 79 Oh SY, Kim JS, Yang TH, Shin BS, Jeong SK. Cervical and ocular vestibular-evoked myogenic potentials in vestibular neuritis: comparison between air- and bone-conducted stimulation. J Neurol 2013; 260 (08) 2102-2109
  • 80 Govender S, Dennis DL, Colebatch JG. Vestibular evoked myogenic potentials (VEMPs) evoked by air- and bone-conducted stimuli in vestibular neuritis. Clin Neurophysiol 2015; 126 (10) 2004-2013
  • 81 Magliulo G, Iannella G, Gagliardi S, Re M. A 1-year follow-up study with C-VEMPs, O-VEMPs and video head impulse testing in vestibular neuritis. Eur Arch Otorhinolaryngol 2015; 272 (11) 3277-3281
  • 82 Taylor RL, McGarvie LA, Reid N, Young AS, Halmagyi GM, Welgampola MS. Vestibular neuritis affects both superior and inferior vestibular nerves. Neurology 2016; 87 (16) 1704-1712
  • 83 Walther LE, Blödow A. Ocular vestibular evoked myogenic potential to air conducted sound stimulation and video head impulse test in acute vestibular neuritis. Otol Neurotol 2013; 34 (06) 1084-1089
  • 84 Goebel JA, O'Mara W, Gianoli G. Anatomic considerations in vestibular neuritis. Otol Neurotol 2001; 22 (04) 512-518
  • 85 Magliulo G, Gagliardi S, Ciniglio Appiani M, Iannella G, Re M. Vestibular neurolabyrinthitis: a follow-up study with cervical and ocular vestibular evoked myogenic potentials and the video head impulse test. Ann Otol Rhinol Laryngol 2014; 123 (03) 162-173
  • 86 Shin BS, Oh SY, Kim JS. , et al. Cervical and ocular vestibular-evoked myogenic potentials in acute vestibular neuritis. Clin Neurophysiol 2012; 123 (02) 369-375
  • 87 Adamec I, Skorić MK, Handžić J. , et al. The role of cervical and ocular vestibular-evoked myogenic potentials in the follow-up of vestibular neuritis. Clin EEG Neurosci 2014; 45 (02) 129-136
  • 88 Kim JS, Kim HJ. Inferior vestibular neuritis. J Neurol 2012; 259 (08) 1553-1560
  • 89 Murofushi T, Iwasaki S, Ushio M. Recovery of vestibular evoked myogenic potentials after a vertigo attack due to vestibular neuritis. Acta Otolaryngol 2006; 126 (04) 364-367
  • 90 Kim HA, Hong JH, Lee H. , et al. Otolith dysfunction in vestibular neuritis: recovery pattern and a predictor of symptom recovery. Neurology 2008; 70 (06) 449-453
  • 91 Chiarovano E, Darlington C, Vidal PP, Lamas G, de Waele C. The role of cervical and ocular vestibular evoked myogenic potentials in the assessment of patients with vestibular schwannomas. PLoS One 2014; 9 (08) e105026
  • 92 Taylor RL, Kong J, Flanagan S. , et al. Prevalence of vestibular dysfunction in patients with vestibular schwannoma using video head-impulses and vestibular-evoked potentials. J Neurol 2015; 262 (05) 1228-1237
  • 93 Ogawa Y, Otsuka K, Inagaki T. , et al. Comparison of cervical vestibular evoked potentials evoked by air-conducted sound and bone-conducted vibration in vestibular Schwannoma patients. Acta Otolaryngol 2018; 138 (10) 898-903
  • 94 Kinoshita M, Iwasaki S, Fujimoto C. , et al. Ocular vestibular evoked myogenic potentials in response to air-conducted sound and bone-conducted vibration in vestibular schwannoma. Otol Neurotol 2013; 34 (07) 1342-1348
  • 95 Lin KL, Chen CM, Wang SJ, Young YH. Correlating vestibular schwannoma size with vestibular-evoked myogenic potential results. Ear Hear 2014; 35 (05) 571-576
  • 96 Jacob A, Robinson Jr LL, Bortman JS, Yu L, Dodson EE, Welling DB. Nerve of origin, tumor size, hearing preservation, and facial nerve outcomes in 359 vestibular schwannoma resections at a tertiary care academic center. Laryngoscope 2007; 117 (12) 2087-2092
  • 97 He YB, Yu CJ, Ji HM, Qu YM, Chen N. Significance of vestibular testing on distinguishing the nerve of origin for vestibular schwannoma and predicting the preservation of hearing. Chin Med J (Engl) 2016; 129 (07) 799-803
  • 98 Suzuki M, Yamada C, Inoue R, Kashio A, Saito Y, Nakanishi W. Analysis of vestibular testing in patients with vestibular schwannoma based on the nerve of origin, the localization, and the size of the tumor. Otol Neurotol 2008; 29 (07) 1029-1033
  • 99 Ushio M, Iwasaki S, Chihara Y. , et al. Is the nerve origin of the vestibular schwannoma correlated with vestibular evoked myogenic potential, caloric test, and auditory brainstem response?. Acta Otolaryngol 2009; 129 (10) 1095-1100
  • 100 Roosli C, Linthicum Jr FH, Cureoglu S, Merchant SN. Dysfunction of the cochlea contributing to hearing loss in acoustic neuromas: an underappreciated entity. Otol Neurotol 2012; 33 (03) 473-480
  • 101 Hızlı Ö, Cureoglu S, Kaya S, Schachern PA, Paparella MM, Adams ME. Quantitative vestibular labyrinthine otopathology in temporal bones with vestibular schwannoma. Otolaryngol Head Neck Surg 2016; 154 (01) 150-156
  • 102 Tufarelli D, Meli A, Labini FS. , et al. Balance impairment after acoustic neuroma surgery. Otol Neurotol 2007; 28 (06) 814-821
  • 103 Tjernström F, Fransson PA, Kahlon B. , et al. Hearing and vestibular function after preoperative intratympanic gentamicin therapy for vestibular schwannoma as part of vestibular prehab. Ear Hear 2016; 37 (06) 744-750
  • 104 Hochet B, Achard S, Lorenz MB. , et al. Preoperative assessment of cervical vestibular evoked myogenic potentials (cVEMPs) help in predicting hearing preservation after removal of vestibular schwannomas through a middle fossa craniotomy. Otol Neurotol 2018; 39 (10) e1143-e1149
  • 105 Sheykholeslami K, Schmerber S, Habiby Kermany M, Kaga K. Sacculo-collic pathway dysfunction accompanying auditory neuropathy. Acta Otolaryngol 2005; 125 (07) 786-791
  • 106 Sazgar AA, Yazdani N, Rezazadeh N, Yazdi AK. Vestibular evoked myogenic potential (VEMP) in patients with auditory neuropathy: auditory neuropathy or audiovestibular neuropathy?. Acta Otolaryngol 2010; 130 (10) 1130-1134
  • 107 Sinha SK, Shankar K, Sharanya R. Cervical and ocular vestibular evoked myogenic potentials test results in individuals with auditory neuropathy spectrum disorders. Audiology Res 2013; 3 (01) e4
  • 108 Magliulo G, Iannella G, Manno A. , et al. Chronic inflammatory demyelinating polyneuropathy: evaluation of the vestibular system with cervical and ocular vestibular evoked myogenic potentials. Eur Arch Otorhinolaryngol 2018; 275 (06) 1507-1512
  • 109 Blanquet M, Petersen JA, Palla A. , et al. Vestibulo-cochlear function in inflammatory neuropathies. Clin Neurophysiol 2018; 129 (04) 863-873
  • 110 Taylor RL, Jankelowitz SK, Young AS, Sullivan D, Halmagyi GM, Welgampola MS. Reversible vestibular neuropathy in adult Refsum disease. Neurology 2018; 90 (19) 890-892
  • 111 Jacot E, Wiener-Vacher S. Potential value of vestibular evoked myogenic potentials in paediatric neuropathies. J Vestib Res 2008; 18 (04) 231-237
  • 112 Strupp M, Kim JS, Murofushi T. , et al. Bilateral vestibulopathy: diagnostic criteria consensus document of the Classification Committee of the Bárány Society. J Vestib Res 2017; 27 (04) 177-189
  • 113 Szmulewicz DJ, McLean CA, Rodriguez ML. , et al. Dorsal root ganglionopathy is responsible for the sensory impairment in CANVAS. Neurology 2014; 82 (16) 1410-1415
  • 114 Strupp M, Feil K, Dieterich M, Brandt T. Bilateral vestibulopathy. Handb Clin Neurol 2016; 137: 235-240
  • 115 Zingler VC, Weintz E, Jahn K. , et al. Saccular function less affected than canal function in bilateral vestibulopathy. J Neurol 2008; 255 (09) 1332-1336
  • 116 Agrawal Y, Bremova T, Kremmyda O, Strupp M. Semicircular canal, saccular and utricular function in patients with bilateral vestibulopathy: analysis based on etiology. J Neurol 2013; 260 (03) 876-883
  • 117 Radtke A, Lempert T, Gresty MA, Brookes GB, Bronstein AM, Neuhauser H. Migraine and Ménière's disease: is there a link?. Neurology 2002; 59 (11) 1700-1704
  • 118 Zaleski A, Bogle J, Starling A. , et al. Vestibular evoked myogenic potentials in patients with vestibular migraine. Otol Neurotol 2015; 36 (02) 295-302
  • 119 Makowiec KF, Piker EG, Jacobson GP, Ramadan NM, Roberts RA. Ocular and cervical vestibular evoked myogenic potentials in patients with vestibular migraine. Otol Neurotol 2018; 39 (07) e561-e567
  • 120 Murofushi T, Tsubota M, Suizu R, Yoshimura E. Is alteration of tuning property in cervical vestibular-evoked myogenic potential specific for Ménière's Disease?. Front Neurol 2017; 8: 193
  • 121 Gabelić T, Krbot Skorić M, Adamec I, Barun B, Zadro I, Habek M. The vestibular evoked myogenic potentials (VEMP) score: a promising tool for evaluation of brainstem involvement in multiple sclerosis. Eur J Neurol 2015; 22 (02) 261-269 , e21
  • 122 Versino M, Colnaghi S, Callieco R, Bergamaschi R, Romani A, Cosi V. Vestibular evoked myogenic potentials in multiple sclerosis patients. Clin Neurophysiol 2002; 113 (09) 1464-1469
  • 123 Alpini D, Pugnetti L, Caputo D, Cesarani A. Vestibular evoked myogenic potentials in multiple sclerosis: a comparison between onset and definite cases. Int Tinnitus J 2005; 11 (01) 48-51
  • 124 Patkó T, Simó M, Arányi Z. Vestibular click-evoked myogenic potentials: sensitivity and factors determining abnormality in patients with multiple sclerosis. Mult Scler 2007; 13 (02) 193-198
  • 125 Kavasoğlu G, Gökçay F, Yüceyar N, Çelebisoy N. Cervical vestibular-evoked myogenic potentials in patients with multiple sclerosis: sensitive in detecting brainstem involvement?. Neurol Sci 2018; 39 (02) 365-371
  • 126 Gazioglu S, Boz C. Ocular and cervical vestibular evoked myogenic potentials in multiple sclerosis patients. Clin Neurophysiol 2012; 123 (09) 1872-1879
  • 127 Rosengren SM, Colebatch JG. Ocular vestibular evoked myogenic potentials are abnormal in internuclear ophthalmoplegia. Clin Neurophysiol 2011; 122 (06) 1264-1267
  • 128 Parsa MS, Mohammadkhani G, Hajabolhassani F, Jalaee S, Zakeri H. Cervical and ocular vestibular evoked myogenic potentials in multiple sclerosis participants. Med J Islam Repub Iran 2015; 29: 164
  • 129 Nerrant E, Tilikete C. Ocular motor manifestations of multiple sclerosis. J Neuroophthalmol 2017; 37 (03) 332-340
  • 130 Curthoys IS, Vulovic V, Burgess AM, Sokolic L, Goonetilleke SC. The response of guinea pig primary utricular and saccular irregular neurons to bone-conducted vibration (BCV) and air-conducted sound (ACS). Hear Res 2016; 331: 131-143
  • 131 Crnošija L, Krbot Skorić M, Gabelić T, Adamec I, Habek M. Vestibular evoked myogenic potentials and MRI in early multiple sclerosis: validation of the VEMP score. J Neurol Sci 2017; 372: 28-32
  • 132 Kim HJ, Kim S, Park JH, Kim JS. Altered processing of otolithic information in isolated lateral medullary infarction. J Neurol 2016; 263 (12) 2424-2429
  • 133 Heide G, Luft B, Franke J, Schmidt P, Witte OW, Axer H. Brainstem representation of vestibular evoked myogenic potentials. Clin Neurophysiol 2010; 121 (07) 1102-1108
  • 134 Oh SY, Kim JS, Lee JM. , et al. Ocular vestibular evoked myogenic potentials induced by air-conducted sound in patients with acute brainstem lesions. Clin Neurophysiol 2013; 124 (04) 770-778
  • 135 Kim HJ, Lee JH, Kim JS. Ocular vestibular evoked myogenic potentials to head tap and cervical vestibular evoked myogenic potentials to air-conducted sounds in isolated internuclear ophthalmoplegia. Clin Neurophysiol 2014; 125 (05) 1042-1047
  • 136 Choi SY, Lee SH, Kim HJ, Kim JS. Impaired modulation of the otolithic function in acute unilateral cerebellar infarction. Cerebellum 2014; 13 (03) 362-371
  • 137 Weng YC, Young YH. Mapping affected territory of anterior/posterior inferior cerebellar artery infarction using a vestibular test battery. Acta Otolaryngol 2014; 134 (03) 268-274
  • 138 Ahn BH, Kim HA, Yi HA, Oh SY, Lee H. Abnormal cervical vestibular-evoked myogenic potential in anterior inferior cerebellar artery territory infarction: frequency, pattern, and a determinant. J Neurol Sci 2011; 307 (1-2): 114-119
  • 139 Pogson JM, Taylor RL, Young AS. , et al. Vertigo with sudden hearing loss: audio-vestibular characteristics. J Neurol 2016; 263 (10) 2086-2096
  • 140 Pötter-Nerger M, Reich MM, Colebatch JG, Deuschl G, Volkmann J. Differential effect of dopa and subthalamic stimulation on vestibular activity in Parkinson's disease. Mov Disord 2012; 27 (10) 1268-1275
  • 141 Pötter-Nerger M, Govender S, Deuschl G, Volkmann J, Colebatch JG. Selective changes of ocular vestibular myogenic potentials in Parkinson's disease. Mov Disord 2015; 30 (04) 584-589
  • 142 de Natale ER, Ginatempo F, Paulus KS. , et al. Abnormalities of vestibular-evoked myogenic potentials in idiopathic Parkinson's disease are associated with clinical evidence of brainstem involvement. Neurol Sci 2015; 36 (06) 995-1001
  • 143 de Natale ER, Ginatempo F, Paulus KS. , et al. Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson's disease. Clin Neurophysiol 2015; 126 (10) 1871-1878
  • 144 Venhovens J, Meulstee J, Bloem BR, Verhagen WI. Neurovestibular analysis and falls in Parkinson's disease and atypical parkinsonism. Eur J Neurosci 2016; 43 (12) 1636-1646
  • 145 Liu X, Zhang S, Huang X, Zhang Y, Fan D. Vestibular evoked myogenic potentials and their clinical utility in patients with amyotrophic lateral sclerosis. Clin Neurophysiol 2019; 130 (05) 647-654
  • 146 Kiliç S, Gazioglu S, Serap Zengin K, Ulkü Dübüş H, Boz C. Cervical vestibular evoked myogenic potentials to air-conducted sound in early amyotrophic lateral sclerosis. Neurophysiol Clin 2012; 42 (03) 119-123
  • 147 Grob D, Brunner N, Namba T, Pagala M. Lifetime course of myasthenia gravis. Muscle Nerve 2008; 37 (02) 141-149
  • 148 Valko Y, Rosengren SM, Jung HH, Straumann D, Landau K, Weber KP. Ocular vestibular evoked myogenic potentials as a test for myasthenia gravis. Neurology 2016; 86 (07) 660-668
  • 149 El-Sayed Mojahed M, Thabet EM, El-Khateeb MG, Elsayed Morgan A. Ocular vestibular evoked myogenic potential in patients with myasthenia gravis: a prospective clinical study. Auris Nasus Larynx 2018; 45 (03) 407-411
  • 150 Jankovic J, Leder S, Warner D, Schwartz K. Cervical dystonia: clinical findings and associated movement disorders. Neurology 1991; 41 (07) 1088-1091
  • 151 Stell R, Bronstein AM, Marsden CD. Vestibulo-ocular abnormalities in spasmodic torticollis before and after botulinum toxin injections. J Neurol Neurosurg Psychiatry 1989; 52 (01) 57-62
  • 152 Rosengren SM, Colebatch JG. Vestibular evoked myogenic potentials are intact in cervical dystonia. Mov Disord 2010; 25 (16) 2845-2853