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Semin Thromb Hemost 2020; 46(01): 050-061
DOI: 10.1055/s-0039-1697951
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Platelet Transfusion in Perioperative Medicine

Thomas Thiele
1   Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany
,
Andreas Greinacher
1   Institut für Immunologie und Transfusionsmedizin, Universitätsmedizin Greifswald, Greifswald, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
12 December 2019 (online)

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Abstract

Platelet transfusions aim to improve primary hemostasis and to prevent or treat bleeding in patients with reduced platelet numbers and/or platelet function. In this review, the authors address the role of platelet transfusions with a focus on perioperative medicine. They summarize different causes of thrombocytopenia in perioperative patients, describe general characteristics and potential adverse effects of different platelet concentrates, describe principles of perioperative platelet transfusion strategies, and highlight specific perioperative scenarios, for example, in patients undergoing antiplatelet therapy. The evidence for any transfusion threshold in perioperative patients based on platelet numbers is low. The evidence supporting prophylactic platelet transfusions in the perioperative setting is very low, and all recommended thresholds for preintervention platelet transfusions are based on weak evidence or expert opinion. Besides the platelet count, platelet function, additional risk factors for bleeding, and the pharmacokinetic properties of concomitant antiplatelet drugs are important criteria for the decision to transfuse or not to transfuse platelets. The few available prospective trials give at least a signal that a liberal platelet transfusion strategy might be associated with poorer outcomes compared with a restrictive platelet transfusion strategy in critically ill patients. Given the unknown risks for adverse outcomes, a therapeutic transfusion strategy during surgery (eventually guided by point of care testing in cardiac surgery, major liver surgery, and major trauma) may be most appropriate for interventions, in which intraoperative bleeding can be controlled until platelets are available, and during the postsurgery period.

Keywords

platelet - perioperative - transfusion - thrombocytopenia - antiplatelet therapy
 

  • References

  • 1 Levy JH, Neal MD, Herman JH. Bacterial contamination of platelets for transfusion: strategies for prevention. Crit Care 2018; 22 (01) 271
    CrossrefPubMedGoogle Scholar
  • 2 Devine DV, Schubert P. Pathogen inactivation technologies: the advent of pathogen-reduced blood components to reduce blood safety risk. Hematol Oncol Clin North Am 2016; 30 (03) 609-617
    CrossrefPubMedGoogle Scholar
  • 3 Burkhart JM, Gambaryan S, Watson SP. , et al. What can proteomics tell us about platelets?. Circ Res 2014; 114 (07) 1204-1219
    CrossrefPubMedGoogle Scholar
  • 4 Sut C, Tariket S, Aubron C. , et al. The non-hemostatic aspects of transfused platelets. Front Med (Lausanne) 2018; 5: 42
    CrossrefPubMedGoogle Scholar
  • 5 Handtke S, Steil L, Greinacher A, Thiele T. Toward the relevance of platelet subpopulations for transfusion medicine. Front Med (Lausanne) 2018; 5: 17
    CrossrefPubMedGoogle Scholar
  • 6 Handtke S, Steil L, Palankar R. , et al. Role of platelet size revisited-function and protein composition of large and small platelets. Thromb Haemost 2019; 119 (03) 407-420
    Article in Thieme ConnectPubMedGoogle Scholar
  • 7 Curley A, Stanworth SJ, Willoughby K. , et al; PlaNeT2 MATISSE Collaborators. Randomized trial of platelet-transfusion thresholds in neonates. N Engl J Med 2019; 380 (03) 242-251
    CrossrefPubMedGoogle Scholar
  • 8 Baharoglu MI, Cordonnier C, Salman RA. , et al; PATCH Investigators. Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial. Lancet 2016; 387 (10038): 2605-2613
    CrossrefPubMedGoogle Scholar
  • 9 Estcourt LJ, Birchall J, Allard S. , et al; British Committee for Standards in Haematology. Guidelines for the use of platelet transfusions. Br J Haematol 2017; 176 (03) 365-394
    CrossrefPubMedGoogle Scholar
  • 10 Kaufman RM, Djulbegovic B, Gernsheimer T. , et al; AABB. Platelet transfusion: a clinical practice guideline from the AABB. Ann Intern Med 2015; 162 (03) 205-213
    CrossrefPubMedGoogle Scholar
  • 11 Nahirniak S, Slichter SJ, Tanael S. , et al; International Collaboration for Transfusion Medicine Guidelines. Guidance on platelet transfusion for patients with hypoproliferative thrombocytopenia. Transfus Med Rev 2015; 29 (01) 3-13
    CrossrefPubMedGoogle Scholar
  • 12 Schiffer CA, Bohlke K, Delaney M. , et al. Platelet transfusion for patients with cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol 2018; 36 (03) 283-299
    PubMedGoogle Scholar
  • 13 Thiele T, Selleng K, Selleng S, Greinacher A, Bakchoul T. Thrombocytopenia in the intensive care unit-diagnostic approach and management. Semin Hematol 2013; 50 (03) 239-250
    CrossrefPubMedGoogle Scholar
  • 14 Grozovsky R, Begonja AJ, Liu K. , et al. The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. Nat Med 2015; 21 (01) 47-54
    CrossrefPubMedGoogle Scholar
  • 15 Li R, Hoffmeister KM, Falet H. Glycans and the platelet life cycle. Platelets 2016; 27 (06) 505-511
    CrossrefPubMedGoogle Scholar
  • 16 Arnold DM, Lim W. A rational approach to the diagnosis and management of thrombocytopenia in the hospitalized patient. Semin Hematol 2011; 48 (04) 251-258
    CrossrefPubMedGoogle Scholar
  • 17 Weil IA, Kumar P, Seicean S, Neuhauser D, Seicean A. Platelet count abnormalities and peri-operative outcomes in adults undergoing elective, non-cardiac surgery. PLoS One 2019; 14 (02) e0212191
    CrossrefPubMedGoogle Scholar
  • 18 Hui P, Cook DJ, Lim W, Fraser GA, Arnold DM. The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review. Chest 2011; 139 (02) 271-278
    CrossrefPubMedGoogle Scholar
  • 19 Nijsten MW, ten Duis HJ, Zijlstra JG. , et al. Blunted rise in platelet count in critically ill patients is associated with worse outcome. Crit Care Med 2000; 28 (12) 3843-3846
    CrossrefPubMedGoogle Scholar
  • 20 Lubenow N, Hinz P, Thomaschewski S. , et al. The severity of trauma determines the immune response to PF4/heparin and the frequency of heparin-induced thrombocytopenia. Blood 2010; 115 (09) 1797-1803
    CrossrefPubMedGoogle Scholar
  • 21 Greinacher A, Selleng S. How I evaluate and treat thrombocytopenia in the intensive care unit patient. Blood 2016; 128 (26) 3032-3042
    PubMedGoogle Scholar
  • 22 Greinacher A, Selleng K. Thrombocytopenia in the intensive care unit patient. Hematology (AmSoc Hematol Educ Program) 2010; 2010: 135-143
    CrossrefPubMedGoogle Scholar
  • 23 Warkentin TE, Levine MN, Hirsh J. , et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med 1995; 332 (20) 1330-1335
    CrossrefPubMedGoogle Scholar
  • 24 Pouplard C, May MA, Iochmann S. , et al. Antibodies to platelet factor 4-heparin after cardiopulmonary bypass in patients anticoagulated with unfractionated heparin or a low-molecular-weight heparin: clinical implications for heparin-induced thrombocytopenia. Circulation 1999; 99 (19) 2530-2536
    CrossrefPubMedGoogle Scholar
  • 25 Selleng S, Malowsky B, Strobel U. , et al. Early-onset and persisting thrombocytopenia in post-cardiac surgery patients is rarely due to heparin-induced thrombocytopenia, even when antibody tests are positive. J Thromb Haemost 2010; 8 (01) 30-36
    CrossrefPubMedGoogle Scholar
  • 26 Greinacher A, Warkentin TE. Acquired non-immune thrombocytopenia. In: Marder VJ, Aird WC, Bennett JS. , eds., Hemostasis and Thrombosis: Basic Principles and Clinical Practice. 6 ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013
    Google Scholar
  • 27 Hiippala ST, Myllylä GJ, Vahtera EM. Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg 1995; 81 (02) 360-365
    PubMedGoogle Scholar
  • 28 Rossaint R, Bouillon B, Cerny V. , et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care 2016; 20: 100
    CrossrefPubMedGoogle Scholar
  • 29 Spahn DR, Bouillon B, Cerny V. , et al. Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care 2013; 17 (02) R76
    CrossrefPubMedGoogle Scholar
  • 30 Hayward CP. Diagnostic evaluation of platelet function disorders. Blood Rev 2011; 25 (04) 169-173
    CrossrefPubMedGoogle Scholar
  • 31 Schnabel RB, Wilde S, Wild PS, Munzel T, Blankenberg S. Atrial fibrillation: its prevalence and risk factor profile in the German general population. Dtsch Arztebl Int 2012; 109 (16) 293-299
    CrossrefPubMedGoogle Scholar
  • 32 Koscielny J, Ziemer S, Radtke H. , et al. A practical concept for preoperative identification of patients with impaired primary hemostasis. Clin Appl Thromb Hemost 2004; 10 (03) 195-204
    CrossrefPubMedGoogle Scholar
  • 33 Chee YL, Crawford JC, Watson HG, Greaves M. ; British Committee for Standards in Haematology. Guidelines on the assessment of bleeding risk prior to surgery or invasive procedures. Br J Haematol 2008; 140 (05) 496-504
    CrossrefPubMedGoogle Scholar
  • 34 Casari C, Bergmeier W. Acquired platelet disorders. Thromb Res 2016; 141 (Suppl. 02) S73-S75
    CrossrefPubMedGoogle Scholar
  • 35 Lukito P, Wong A, Jing J. , et al. Mechanical circulatory support is associated with loss of platelet receptors glycoprotein Ibα and glycoprotein VI. J Thromb Haemost 2016; 14 (11) 2253-2260
    CrossrefPubMedGoogle Scholar
  • 36 Hamzeh-Cognasse H, Damien P, Chabert A, Pozzetto B, Cognasse F, Garraud O. Platelets and infections - complex interactions with bacteria. Front Immunol 2015; 6: 82
    PubMedGoogle Scholar
  • 37 Thiele T, Alt-Mayer T, Greinacher A, Bux J. Implications of a switch to a 100% apheresis platelet supply for patients and for blood donors: a risk benefit analysis. Vox Sang 2016; 111 (04) 350-356
    CrossrefPubMedGoogle Scholar
  • 38 Thiele T, Heddle N, Greinacher A. Donor exposures in recipients of pooled platelet concentrates. N Engl J Med 2013; 368 (05) 487-489
    CrossrefPubMedGoogle Scholar
  • 39 Tynngård N. Preparation, storage and quality control of platelet concentrates. Transfus Apheresis Sci 2009; 41 (02) 97-104
    CrossrefPubMedGoogle Scholar
  • 40 Vassallo RR, Murphy S. A critical comparison of platelet preparation methods. Curr Opin Hematol 2006; 13 (05) 323-330
    CrossrefPubMedGoogle Scholar
  • 41 Jutzi M, Mansouri Taleghani B, Rueesch M, Amsler L, Buser A. Nationwide implementation of pathogen inactivation for all platelet concentrates in Switzerland. Transfus Med Hemother 2018; 45 (03) 151-156
    CrossrefPubMedGoogle Scholar
  • 42 Prudent M, D'Alessandro A, Cazenave JP. , et al. Proteome changes in platelets after pathogen inactivation--an interlaboratory consensus. Transfus Med Rev 2014; 28 (02) 72-83
    CrossrefPubMedGoogle Scholar
  • 43 Estcourt LJ, Malouf R, Hopewell S. , et al. Pathogen-reduced platelets for the prevention of bleeding. Cochrane Database Syst Rev 2017; 7: CD009072
    PubMedGoogle Scholar
  • 44 Slichter SJ, Kaufman RM, Assmann SF. , et al. Dose of prophylactic platelet transfusions and prevention of hemorrhage. N Engl J Med 2010; 362 (07) 600-613
    CrossrefPubMedGoogle Scholar
  • 45 Aubron C, Flint AWJ, Ozier Y, McQuilten Z. Platelet storage duration and its clinical and transfusion outcomes: a systematic review. Crit Care 2018; 22 (01) 185
    CrossrefPubMedGoogle Scholar
  • 46 Marini I, Aurich K, Jouni R. , et al. Cold storage of platelets in additive solution: the impact of residual plasma in apheresis platelet concentrates. Haematologica 2019; 104 (01) 207-214
    CrossrefPubMedGoogle Scholar
  • 47 Noorman F, van Dongen TT, Plat MJ, Badloe JF, Hess JR, Hoencamp R. Transfusion: -80°C frozen blood products are safe and effective in military casualty care. PLoS One 2016; 11 (12) e0168401
    CrossrefPubMedGoogle Scholar
  • 48 Johnson L, Tan S, Wood B, Davis A, Marks DC. Refrigeration and cryopreservation of platelets differentially affect platelet metabolism and function: a comparison with conventional platelet storage conditions. Transfusion 2016; 56 (07) 1807-1818
    CrossrefPubMedGoogle Scholar
  • 49 Michael Fitzpatrick G. Novel platelet products under development for the treatment of thrombocytopenia or acute hemorrhage. Transfus Apheresis Sci 2019; 58 (01) 7-11
    CrossrefPubMedGoogle Scholar
  • 50 Kelly K, Dumont LJ. Frozen platelets. Transfus Apheresis Sci 2019; 58 (01) 23-29
    CrossrefPubMedGoogle Scholar
  • 51 Marks DC. Cryopreserved platelets: are we there yet?. Transfusion 2018; 58 (09) 2092-2094
    CrossrefPubMedGoogle Scholar
  • 52 Slichter SJ, Dumont LJ, Cancelas JA. , et al. Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia. Transfusion 2018; 58 (09) 2129-2138
    CrossrefPubMedGoogle Scholar
  • 53 Magron A, Laugier J, Provost P, Boilard E. Pathogen reduction technologies: The pros and cons for platelet transfusion. Platelets 2018; 29 (01) 2-8
    CrossrefPubMedGoogle Scholar
  • 54 Nurden AT. Acquired antibodies to alphaIIbbeta3 in Glanzmann thrombasthenia: from transfusion and pregnancy to bone marrow transplants and beyond. Transfus Med Rev 2018 ; doi: 10.1016/j.tmrv.2018.05.002. [Epub ahead of print]
    PubMedGoogle Scholar
  • 55 Balduini CL, Melazzini F, Pecci A. Inherited thrombocytopenias-recent advances in clinical and molecular aspects. Platelets 2017; 28 (01) 3-13
    CrossrefPubMedGoogle Scholar
  • 56 Pecci A. Diagnosis and treatment of inherited thrombocytopenias. Clin Genet 2016; 89 (02) 141-153
    CrossrefPubMedGoogle Scholar
  • 57 Daly PA, Schiffer CA, Aisner J, Wiernik PH. Platelet transfusion therapy. One-hour posttransfusion increments are valuable in predicting the need for HLA-matched preparations. JAMA 1980; 243 (05) 435-438
    CrossrefPubMedGoogle Scholar
  • 58 Murphy MF, Waters AH. Platelet transfusions: the problem of refractoriness. Blood Rev 1990; 4 (01) 16-24
    CrossrefPubMedGoogle Scholar
  • 59 Goel R, Ness PM, Takemoto CM, Krishnamurti L, King KE, Tobian AA. Platelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in-hospital mortality. Blood 2015; 125 (09) 1470-1476
    CrossrefPubMedGoogle Scholar
  • 60 van Hout FMA, van der Meer PF, Wiersum-Osselton JC. , et al. Transfusion reactions after transfusion of platelets stored in PAS-B, PAS-C, or plasma: a nationwide comparison. Transfusion 2018; 58 (04) 1021-1027
    CrossrefPubMedGoogle Scholar
  • 61 Cohn CS, Stubbs J, Schwartz J. , et al. A comparison of adverse reaction rates for PAS C versus plasma platelet units. Transfusion 2014; 54 (08) 1927-1934
    CrossrefPubMedGoogle Scholar
  • 62 Warkentin TE, Morin PA, Heddle NM. Neutropenia and monocytopenia in recurrent anaphylactoid reactions after red blood cell transfusions in a woman with immunoglobulin A (IgA) deficiency and anti-IgA. Transfusion 2018; 58 (10) 2320-2325
    CrossrefPubMedGoogle Scholar
  • 63 Cohen R, Escorcia A, Tasmin F. , et al. Feeling the burn: the significant burden of febrile nonhemolytic transfusion reactions. Transfusion 2017; 57 (07) 1674-1683
    CrossrefPubMedGoogle Scholar
  • 64 Heddle NM, Klama L, Singer J. , et al. The role of the plasma from platelet concentrates in transfusion reactions. N Engl J Med 1994; 331 (10) 625-628
    CrossrefPubMedGoogle Scholar
  • 65 Roubinian N. TACO and TRALI: biology, risk factors, and prevention strategies. Hematology (Am Soc Hematol Educ Program) 2018; 2018 (01) 585-594
    CrossrefPubMedGoogle Scholar
  • 66 Clifford L, Jia Q, Subramanian A, Yadav H, Schroeder DR, Kor DJ. Risk factors and clinical outcomes associated with perioperative transfusion-associated circulatory overload. Anesthesiology 2017; 126 (03) 409-418
    CrossrefPubMedGoogle Scholar
  • 67 Kopko PM, Bux J, Toy P. Antibodies associated with TRALI: differences in clinical relevance. Transfusion 2019; 59 (03) 1147-1151
    PubMedGoogle Scholar
  • 68 Williamson LM, Stainsby D, Jones H. , et al. The impact of universal leukodepletion of the blood supply on hemovigilance reports of posttransfusion purpura and transfusion-associated graft-versus-host disease. Transfusion 2007; 47 (08) 1455-1467
    CrossrefPubMedGoogle Scholar
  • 69 Cook DJ, Crowther MA, Meade MO, Douketis J. ; VTE in the ICU Workshop Participants. Prevalence, incidence, and risk factors for venous thromboembolism in medical-surgical intensive care unit patients. J Crit Care 2005; 20 (04) 309-313
    CrossrefPubMedGoogle Scholar
  • 70 Schmidt AE, Henrichs KF, Kirkley SA, Refaai MA, Blumberg N. Prophylactic preprocedure platelet transfusion is associated with increased risk of thrombosis and mortality. Am J Clin Pathol 2017; 149 (01) 87-94
    PubMedGoogle Scholar
  • 71 Cook D, Crowther M, Meade M. , et al. Deep venous thrombosis in medical-surgical critically ill patients: prevalence, incidence, and risk factors. Crit Care Med 2005; 33 (07) 1565-1571
    CrossrefPubMedGoogle Scholar
  • 72 van Hout FM, Hogervorst EK, Rosseel PM. , et al. Does a platelet transfusion independently affect bleeding and adverse outcomes in cardiac surgery?. Anesthesiology 2017; 126 (03) 441-449
    CrossrefPubMedGoogle Scholar
  • 73 Baschin M, Selleng S, Hummel A. , et al. Preoperative platelet transfusions to reverse antiplatelet therapy for urgent non-cardiac surgery: an observational cohort study. J Thromb Haemost 2018; 16 (04) 709-717
    CrossrefPubMedGoogle Scholar
  • 74 Uhl L, Assmann SF, Hamza TH, Harrison RW, Gernsheimer T, Slichter SJ. Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial. Blood 2017; 130 (10) 1247-1258
    CrossrefPubMedGoogle Scholar
  • 75 Wandt H, Schaefer-Eckart K, Wendelin K. , et al; Study Alliance Leukemia. Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study. Lancet 2012; 380 (9850): 1309-1316
    CrossrefPubMedGoogle Scholar
  • 76 Stanworth SJ, Estcourt LJ, Powter G. , et al; TOPPS Investigators. A no-prophylaxis platelet-transfusion strategy for hematologic cancers. N Engl J Med 2013; 368 (19) 1771-1780
    CrossrefPubMedGoogle Scholar
  • 77 Estcourt LJ, Stanworth SJ, Doree C, Hopewell S, Trivella M, Murphy MF. Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation. Cochrane Database Syst Rev 2015; (11) CD010983
    PubMedGoogle Scholar
  • 78 Vanderschueren S, De Weerdt A, Malbrain M. , et al. Thrombocytopenia and prognosis in intensive care. Crit Care Med 2000; 28 (06) 1871-1876
    CrossrefPubMedGoogle Scholar
  • 79 Strauss R, Wehler M, Mehler K, Kreutzer D, Koebnick C, Hahn EG. Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome. Crit Care Med 2002; 30 (08) 1765-1771
    CrossrefPubMedGoogle Scholar
  • 80 Nammas W, Dalen M, Rosato S. , et al. Impact of preoperative thrombocytopenia on the outcome after coronary artery bypass grafting. Platelets 2019; 30 (04) 480-486
    CrossrefPubMedGoogle Scholar
  • 81 Nascimbene A, Neelamegham S, Frazier OH, Moake JL, Dong JF. Acquired von Willebrand syndrome associated with left ventricular assist device. Blood 2016; 127 (25) 3133-3141
    CrossrefPubMedGoogle Scholar
  • 82 Estcourt LJ, Malouf R, Doree C, Trivella M, Hopewell S, Birchall J. Prophylactic platelet transfusions prior to surgery for people with a low platelet count. Cochrane Database Syst Rev 2018; 9: CD012779
    PubMedGoogle Scholar
  • 83 Estcourt LJ, Desborough M, Hopewell S, Doree C, Stanworth SJ. Comparison of different platelet transfusion thresholds prior to insertion of central lines in patients with thrombocytopenia. Cochrane Database Syst Rev 2015; (12) CD011771
    PubMedGoogle Scholar
  • 84 Li D, Glor T, Jones GA. Thrombocytopenia and neurosurgery: a literature review. World Neurosurg 2017; 106: 277-280
    CrossrefPubMedGoogle Scholar
  • 85 Stanworth SJ, Walsh TS, Prescott RJ. , et al. Thrombocytopenia and platelet transfusion in UK critical care: a multicenter observational study. Transfusion 2012
    PubMedGoogle Scholar
  • 86 Bilgin YM, van de Watering LM, Versteegh MI, van Oers MH, Vamvakas EC, Brand A. Postoperative complications associated with transfusion of platelets and plasma in cardiac surgery. Transfusion 2011; 51 (12) 2603-2610
    CrossrefPubMedGoogle Scholar
  • 87 Lieberman L, Bercovitz RS, Sholapur NS, Heddle NM, Stanworth SJ, Arnold DM. Platelet transfusions for critically ill patients with thrombocytopenia. Blood 2014; 123 (08) 1146-1151 , quiz 1280
    CrossrefPubMedGoogle Scholar
  • 88 Fogarty Mack P. Intracranial haemorrhage: therapeutic interventions and anaesthetic management. Br J Anaesth 2014; 113 (Suppl. 02) ii17-ii25
    CrossrefPubMedGoogle Scholar
  • 89 Roffi M, Patrono C, Collet J-P. , et al; ESC Scientific Document Group. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J 2016; 37 (03) 267-315
    CrossrefPubMedGoogle Scholar
  • 90 Tendera M, Aboyans V, Bartelink ML. , et al; European Stroke Organisation; ESC Committee for Practice Guidelines. ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: the Task Force on the Diagnosis and Treatment of Peripheral Artery Diseases of the European Society of Cardiology (ESC). Eur Heart J 2011; 32 (22) 2851-2906
    CrossrefPubMedGoogle Scholar
  • 91 Rothwell PM, Algra A, Chen Z, Diener HC, Norrving B, Mehta Z. Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials. Lancet 2016; 388 (10042): 365-375
    CrossrefPubMedGoogle Scholar
  • 92 Morrow DA, Braunwald E, Bonaca MP. , et al; TRA 2P–TIMI 50 Steering Committee and Investigators. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med 2012; 366 (15) 1404-1413
    CrossrefPubMedGoogle Scholar
  • 93 García Rodríguez LA, Martín-Pérez M, Hennekens CH, Rothwell PM, Lanas A. Bleeding risk with long-term low-dose aspirin: a systematic review of observational studies. PLoS One 2016; 11 (08) e0160046
    CrossrefPubMedGoogle Scholar
  • 94 Li L, Geraghty OC, Mehta Z, Rothwell PM, Oxford Vascular S. ; Oxford Vascular Study. Age-specific risks, severity, time course, and outcome of bleeding on long-term antiplatelet treatment after vascular events: a population-based cohort study. Lancet 2017; 390 (10093): 490-499
    CrossrefPubMedGoogle Scholar
  • 95 Hao Q, Tampi M, O'Donnell M, Foroutan F, Siemieniuk RA, Guyatt G. Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis. BMJ 2018; 363: k5108
    PubMedGoogle Scholar
  • 96 Devereaux PJ, Mrkobrada M, Sessler DI. , et al; POISE-2 Investigators. Aspirin in patients undergoing noncardiac surgery. N Engl J Med 2014; 370 (16) 1494-1503
    CrossrefPubMedGoogle Scholar
  • 97 Siller-Matula JM, Petre A, Delle-Karth G. , et al. Impact of preoperative use of P2Y12 receptor inhibitors on clinical outcomes in cardiac and non-cardiac surgery: a systematic review and meta-analysis. Eur Heart J Acute Cardiovasc Care 2017; 6 (08) 753-770
    CrossrefPubMedGoogle Scholar
  • 98 Spyropoulos AC, Albaladejo P, Godier A. , et al. Periprocedural antiplatelet therapy: recommendations for standardized reporting in patients on antiplatelet therapy: communication from the SSC of the ISTH. J Thromb Haemost 2013; 11 (08) 1593-1596
    CrossrefPubMedGoogle Scholar
  • 99 Thygesen K, Alpert JS, Jaffe AS. , et al; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction. Fourth universal definition of myocardial infarction (2018). Circulation 2018; 138 (20) e618-e651
    PubMedGoogle Scholar
  • 100 Helwani MA, Amin A, Lavigne P. , et al. Etiology of acute coronary syndrome after noncardiac surgery. Anesthesiology 2018; 128 (06) 1084-1091
    CrossrefPubMedGoogle Scholar
  • 101 Devereaux PJ, Eikelboom J. Insights into myocardial infarction after noncardiac surgery in patients with a prior coronary artery stent. Br J Anaesth 2016; 116 (05) 584-586
    CrossrefPubMedGoogle Scholar
  • 102 Rossini R, Tarantini G, Musumeci G. , et al; Italian Society of Interventional Cardiology (SICI-GISE); Italian Society for the Study of Haemostasis and Thrombosis (SISET); Italian Society of Anesthesia and Intensive Care Medicine (SIAARTI); Italian Society of Surgery (SIC); Italian Society for Cardiac Surgery (SICCH); Italian Society of Vascular and Endovascular Surgery (SICVE); Italian Society of Urology (SIU); Italian Orthopaedic Society (SIOT); Italian Society of Thoracic Surgeons (SICT); Italian Federation of Scientific Societies of Digestive System Diseases (FISMAD); Italian Society of Digestive Endoscopy (SIED); Italian Association of Hospital Gastroenterology and Digestive Endoscopy (AIGO); Italian Association of Gastroenterology and Digestive Endoscopy (SIGE); Italian Society of Maxillofacial Surgery (SICMF); Italian Society of Reconstructive Plastic Surgery and Aesthetics (SICPRE); Italian Society of Gynecology and Obstetrics (SIGO); Italian Society of Neurosurgery (SINch); Italian Association of Hospital Pulmonologist (AIPO); Italian Society of Periodontology (SIdP); Italian Society of Ophthalmology (SOI); Italian Association of Hospital Otorhinolaryngologist (AOOI); Italian Association of Hospital Surgeons (ACOI); Association of Obstetricians Gynecologists Italian Hospital (AOGOI). A multidisciplinary approach on the perioperative antithrombotic management of patients with coronary stents undergoing surgery: surgery after stenting 2. JACC Cardiovasc Interv 2018; 11 (05) 417-434
    CrossrefPubMedGoogle Scholar
  • 103 Li C, Hirsh J, Xie C, Johnston MA, Eikelboom JW. Reversal of the anti-platelet effects of aspirin and clopidogrel. J Thromb Haemost 2012; 10 (04) 521-528
    CrossrefPubMedGoogle Scholar
  • 104 Zafar MU, Santos-Gallego C, Vorchheimer DA. , et al. Platelet function normalization after a prasugrel loading-dose: time-dependent effect of platelet supplementation. J Thromb Haemost 2013; 11 (01) 100-106
    CrossrefPubMedGoogle Scholar
  • 105 Godier A, Taylor G, Gaussem P. Inefficacy of platelet transfusion to reverse ticagrelor. N Engl J Med 2015; 372 (02) 196-197
    CrossrefPubMedGoogle Scholar
  • 106 Teng R, Carlson GF, Nylander S, Andersson TL. Effects of autologous platelet transfusion on platelet inhibition in ticagrelor-treated and clopidogrel-treated subjects. J Thromb Haemost 2016; 14 (12) 2342-2352
    CrossrefPubMedGoogle Scholar
  • 107 Martin AC, Berndt C, Calmette L. , et al. The effectiveness of platelet supplementation for the reversal of ticagrelor-induced inhibition of platelet aggregation: an in-vitro study. Eur J Anaesthesiol 2016; 33 (05) 361-367
    CrossrefPubMedGoogle Scholar
  • 108 Bertling A, Fender AC, Schüngel L. , et al. Reversibility of platelet P2Y12 inhibition by platelet supplementation: ex vivo and in vitro comparisons of prasugrel, clopidogrel and ticagrelor. J Thromb Haemost 2018; 16 (06) 1089-1098
    CrossrefPubMedGoogle Scholar
  • 109 Kruger PC, Hirsh J, Bhagirath VC. , et al. In vitro reversal of the anti-aggregant effect of ticagrelor using untreated platelets. Thromb Haemost 2018; 118 (11) 1895-1901
    Article in Thieme ConnectPubMedGoogle Scholar
  • 110 Wang H, Qi J, Li Y. , et al. Pharmacodynamics and pharmacokinetics of ticagrelor vs. clopidogrel in patients with acute coronary syndromes and chronic kidney disease. Br J Clin Pharmacol 2018; 84 (01) 88-96
    CrossrefPubMedGoogle Scholar
  • 111 Teng R. Ticagrelor: pharmacokinetic, pharmacodynamic and pharmacogenetic profile: an update. Clin Pharmacokinet 2015; 54 (11) 1125-1138
    CrossrefPubMedGoogle Scholar
  • 112 Zafar MU, Smith DA, Baber U. , et al. Impact of timing on the functional recovery achieved with platelet supplementation after treatment with ticagrelor. Circ Cardiovasc Interv 2017; 10 (08) e005120
    PubMedGoogle Scholar
  • 113 Neumann FJ, Sousa-Uva M, Ahlsson A. , et al; ESC Scientific Document Group. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J 2019; 40 (02) 87-165
    CrossrefPubMedGoogle Scholar
  • 114 Fleisher LA, Fleischmann KE, Auerbach AD. , et al. 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014; 130 (24) 2215-2245
    CrossrefPubMedGoogle Scholar
  • 115 Chassot PG, Delabays A, Spahn DR. Perioperative antiplatelet therapy: the case for continuing therapy in patients at risk of myocardial infarction. Br J Anaesth 2007; 99 (03) 316-328
    CrossrefPubMedGoogle Scholar
  • 116 Thiele T, Sümnig A, Hron G. , et al. Platelet transfusion for reversal of dual antiplatelet therapy in patients requiring urgent surgery: a pilot study. J Thromb Haemost 2012; 10 (05) 968-971
    CrossrefPubMedGoogle Scholar
  • 117 Baschin M, Selleng S, Zeden JP. , et al. Platelet transfusion to reverse antiplatelet therapy before decompressive surgery in patients with intracranial haemorrhage. Vox Sang 2017; 112 (06) 535-541
    CrossrefPubMedGoogle Scholar
  • 118 Greinacher A, Kiefel V, Klüter H, Kroll H, Pötzsch B, Riess H. ; Deutsche Gesellschaft für Transfusionsmedizin und Immunhämatologie; Deutsche Gesellschaft für Thrombose- und Hämostaseforschung; Deutsche Gesellschaft für Hämatologie und Onkologie. [Recommendations for platelet transfusion by the Joint Thrombocyte Working Party of the German Societies of Transfusion Medicine and Immunohaematology (DGTI), Thrombosis and Haemostasis Research (GTH), and Haematology and Oncology (DGHO)]. Dtsch Med Wochenschr 2006; 131 (47) 2675-2679
    Article in Thieme ConnectPubMedGoogle Scholar
  • 119 Stainsby D, MacLennan S, Hamilton PJ. Management of massive blood loss: a template guideline. Br J Anaesth 2000; 85 (03) 487-491
    CrossrefPubMedGoogle Scholar
  • 120 McQuilten ZK, Crighton G, Brunskill S. , et al. Optimal dose, timing and ratio of blood products in massive transfusion: results from a systematic review. Transfus Med Rev 2018; 32 (01) 6-15
    CrossrefPubMedGoogle Scholar
  • 121 Winearls J, Reade M, Miles H. , et al. Targeted coagulation management in severe trauma: the controversies and the evidence. Anesth Analg 2016; 123 (04) 910-924
    CrossrefPubMedGoogle Scholar
  • 122 Thomas W, Samama CM, Greinacher A, Hunt BJ. ; Subcommittee on Perioperative and Critical Care. The utility of viscoelastic methods in the prevention and treatment of bleeding and hospital-associated venous thromboembolism in perioperative care: guidance from the SSC of the ISTH. J Thromb Haemost 2018; 16 (11) 2336-2340
    CrossrefPubMedGoogle Scholar
  • 123 Zia AN, Chitlur M, Rajpurkar M. , et al. Thromboelastography identifies children with rare bleeding disorders and predicts bleeding phenotype. Haemophilia 2015; 21 (01) 124-132
    CrossrefPubMedGoogle Scholar
  • 124 De Pietri L, Bianchini M, Montalti R. , et al. Thrombelastography-guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: a randomized, controlled trial. Hepatology 2016; 63 (02) 566-573
    CrossrefPubMedGoogle Scholar
  • 125 Weber CF, Görlinger K, Meininger D. , et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology 2012; 117 (03) 531-547
    CrossrefPubMedGoogle Scholar
  • 126 Görlinger K, Dirkmann D, Hanke AA. Potential value of transfusion protocols in cardiac surgery. Curr Opin Anaesthesiol 2013; 26 (02) 230-243
    CrossrefPubMedGoogle Scholar
  • 127 Serraino GF, Murphy GJ. Routine use of viscoelastic blood tests for diagnosis and treatment of coagulopathic bleeding in cardiac surgery: updated systematic review and meta-analysis. Br J Anaesth 2017; 118 (06) 823-833
    CrossrefPubMedGoogle Scholar
  • 128 National Institute for Health and Care Excellence. Detecting, managing and monitoring haemostasis: viscoelastometric point of care testing (ROTEM, TEG and Sonoclot systems). Available at: https://www.nice.org.uk/guidance/dg13/chapter/1-Recommendations . Published August 2014, last accessed March 2019)
    PubMedGoogle Scholar
  • 129 Foreman PM, Ilyas A, Mooney J, Schmalz PGR, Walters BC, Griessenauer CJ. Antiplatelet medication reversal strategies in operative intracranial hemorrhage: a survey of practicing neurosurgeons. World Neurosurg 2018; 116: e649-e654
    CrossrefPubMedGoogle Scholar
  • 130 Ogunlade J, Wiginton IV JG, Ghanchi H. , et al. Efficacy of platelet transfusion in the management of acute subdural hematoma. Clin Neurol Neurosurg 2018; 174: 163-166
    CrossrefPubMedGoogle Scholar
  • 131 Li X, Sun Z, Zhao W. , et al. Effect of acetylsalicylic acid usage and platelet transfusion on postoperative hemorrhage and activities of daily living in patients with acute intracerebral hemorrhage. J Neurosurg 2013; 118 (01) 94-103
    CrossrefPubMedGoogle Scholar
  • 132 Gulati D, Dua D, Torbey MT. Hemostasis in intracranial hemorrhage. Front Neurol 2017; 8: 80
    PubMedGoogle Scholar
  • 133 Cheng KY, Tsang CP, Leung GKK, Lui WM. The application of point-of-care platelet function assay in guiding platelet transfusion in aspirin-users with intracranial haemorrhages. J Clin Neurosci 2018; 55: 52-56
    CrossrefPubMedGoogle Scholar
  • 134 Pandya U, Malik A, Messina M, Albeiruti AR, Spalding C. Reversal of antiplatelet therapy in traumatic intracranial hemorrhage: Does timing matter?. J Clin Neurosci 2018; 50: 88-92
    CrossrefPubMedGoogle Scholar
  • 135 French SL, Arthur JF, Tran HA, Hamilton JR. Approval of the first protease-activated receptor antagonist: rationale, development, significance, and considerations of a novel anti-platelet agent. Blood Rev 2015; 29 (03) 179-189
    CrossrefPubMedGoogle Scholar
  • 136 Ortel TL. Perioperative management of patients on chronic antithrombotic therapy. Blood 2012; 120 (24) 4699-4705
    PubMedGoogle Scholar