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CC BY 4.0 · Surg J (N Y) 2019; 05(04): e137-e141
DOI: 10.1055/s-0039-1697634
Case Report
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Ossified Spinal Meningioma: A Case Report and a Review of the Literature

Mahmoud M. Taha
1   Department of Neurosurgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt
,
Ahmed Alawamry 
1   Department of Neurosurgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt
,
Hesham R. Abdel-Aziz
2   Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
› Author Affiliations

Funding No financial support received.
Further Information

Address for correspondence

Ahmed Alawamry, MD
Department of Neurosurgery, Faculty of Medicine
Zagazig University, Zagazig 44511
Egypt   

Publication History

02 February 2019

26 July 2019

Publication Date:
01 October 2019 (online)

Also available ateRef
 
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Abstract

Ossified spinal meningiomas are a rare form of spinal tumors. These tumors increase surgical morbidities due to their hard consistency and strong adhesion to the neural tissue and relatively narrow surgical space. Here, the authors describe the clinical findings, surgical strategies, and histological findings of a patient with an ossified meningioma. Preoperative diagnosis of these tumors can prevent surgical morbidities. Total resection can be curative with the application of meticulous microsurgical techniques.


 

Keywords

ossified meningioma - spinal meningioma - intradural extramedullary

Metaplastic meningiomas are a subtype of meningioma characterized by focal mesenchymal differentiation with osseous, cartilaginous, lipomatous, myxoid, or xanthomatous changes.[1] These tumors are most commonly located at intradural extramedullary sites (40% of cases).[2] Ossified meningiomas account for 0.7 to 5.5% of all spinal meningiomas.[3] Symptoms are common, and surgical resection is a technically demanding procedure due to the hard consistency of these tumors and spatial restriction during surgery for spinal tumors.[4]

Case Report

A 22-year-old female presented with progressive heaviness in the lower limbs with gait disturbance, paresthesia of the lower limbs, and sphincter disturbances for approximately 5 weeks. Neurological examination revealed motor power grade of 3 for all muscle groups of the lower limbs and hypoesthesia with a sensory level below T4. Reflexes were exaggerated with positive Babinski and pathological reflexes. Radiological workup including magnetic resonance imaging (MRI) of the dorsal spine showed an intradural extramedullary spinal meningioma opposite the T4 to T5 level with hypointense signals on T1- and T2-weighted images of the tumor that indicated calcification ([Fig. 1A] and [B]). Under general anesthesia and intraoperative neuromonitoring, the patient was positioned in the prone position and a midline-skin incision was made, followed by two levels of total laminectomy without compromising the facet joints. Further, a linear midline incision was made through the relatively tough dura. Early identification of tumor poles and cerebrospinal fluid (CSF) drainage allowed fine neural retraction. Total tumor excision ([Figs. 2] and [3]) was performed using standard microsurgical techniques. Dural attachment was coagulated, and appropriate hemostasis and watertight dural closure were performed. The patient's neurological status improved to full motor power after postoperative 6 weeks using a rehabilitative physiotherapy protocol. Histopathological examination revealed ossified meningioma ([Fig. 4A] and [B]).

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Fig. 1 (A) T1-weighted dorsal spine magnetic resonance imaging (MRI) showing spinal meningioma opposite T4–T5 with hypointense signals denoting calcifications. (B) T2-weighted dorsal spine MRI showing spinal meningioma opposite T4–T5 with hypointense signals denoting calcifications.
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Fig. 2 Intraoperative image of excised ossified meningioma.
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Fig. 3 Postoperative T2-weighted MRI showing complete tumor removal. MRI, magnetic resonance imaging.
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Fig. 4 (A) Photomicrograph showing meningothelial cells, calcified psammoma bodies, and scattered foci of ossification (hematoxylin and eosin [H&E], ×40). (B) Photomicrograph showing areas of irregular, calcified bone trabeculae (star) and calcified psammoma body (arrow; H&E, ×400).

 

Discussion and Review of Literature

Including this report, a total of 33 cases of ossified spinal meningioma have been published till 2019 according to PubMed ([Table 1]). For this condition, female predominance has been clearly noted (female, 31; male, 2). The mean age of patients with this condition is 42.6 years, with the youngest patient being 15 years old. The tumor was located in the thoracic spine in all patients except four (cervical region, three; lumbar region, one). Further, the tumor was located posterior to the spinal cord in 18 patients.

Table 1

Review of ossified meningioma cases

Year

Author

Number of cases

Age and sex

Location

Level

1928

Rogers[19]

1

16/F[a]

Dorsal

T[c]9

1972

Freidberg[20]

1

69/F

Ventral

T1–2

1993

Niijima et al[21]

2

75/F–75/F

Dorsal, ventral

T8–9, T9–10

1994

Kitagawa et al

2

60/F–45/F

Dorsal, lateral

T7–8, c2

1996

Nakayama et al

1

74/F

Dorsal

T9

1999

Huang et al[22]

1

73/F

Lateral

T5

2001

Naderi et al[23]

1

15/F

Dorsal

T4

2006

Liu et al[24]

1

70/F

lateral

T11

2009

Hirabayashi et al[25]

1

82/F

Dorsal

L3

2009

Uchida et al

1

76/F

Ventral

T12

2010

Licci et al[26]

1

58/F

Lateral

T6

2013

Chotai et al[27]

1

61/F

Dorsal

T4–T5

2013

Ju et al[28]

1

61/F

Lateral

T9–10

2013

Taneoka et al[29]

1

78/F

Dorsal

T9

2014

Yamane et al[30]

1

61/F

Ventral

T12

2014

Chan et al[31]

1

64/F

Dorsal

T9–10

2015

Alafaci et al

9

Mean age 59 years/8F–1m[b]

4 ventral, 4 dorsal, 1 lateral

7 thoracic, 2 cervical

2016

Demir et al[32]

1

26/F

Dorsal

T9–t11

2016

Xia et al[33]

1

90/M

Dorsal

T10–T11

2016

Kim et al[34]

2

51/F– 77/F

Dorsal, lateral

T4, t9

2018

Prakash et al[35]

1

60/F

Dorsal,

T7–T8

a Female.


b Male.


c Thoracic.


Spinal meningiomas arise from the arachnoid villi of spinal nerve roots and are located within the intradural space in most cases.[5] Except complete psammomatous transformation, the pathogenesis of ossification remains unclear; some theories suggest that meningioma ossification occurs secondary to metaplasia of arachnoid or interstitial cells on exposure to osteoblast-transforming factors such as Sox9.[6] The selection of the initial site of mineralization and mode of calcification in psammoma bodies is attributed to hydroxyapatite crystal precipitation within the bodies which result in the formation of large psammoma bodies. Then, collagen fibers surrounding the calcified bodies accumulate deposits of apatite crystals, forming larger psammoma bodies.[7] In addition, estrogen deficiency is hypothesized to enhance the process of calcification in areas containing necrotic fibroblasts and increased number of collagen fibrils.[8] [9] Uchida et al reported that premature arachnoid cells with pluripotency differentiate into metaplastic cells and lead to bone formation.[8]

The clinical features of ossified spinal meningiomas include motor, sensory, and sphincter dysfunctions, which exhibit different phenotypes according to the tumor location and neural compression.[10]

Ruggeri et al observed a statistically significant relationship between postoperative neurological status and the degree of meningioma ossification wherein surgical morbidity increased with calcified and ossified tumors.[11] Detection of ossification is important during preoperative planning and preparation for safe tumor resection. Although MRI is considered as the best noninvasive neuroimaging technique, it cannot detect small amounts of calcification. High-signal areas on computed tomography (CT) are the most important radiological features for ossification detection.[12]

The surgical strategy for ossified meningiomas differs from that for other classical cases of meningiomas because central tumor debulking can be challenging. Using an ultrasonic surgical aspirator is helpful for hard tissue removal, including bone removal; however, it may result in neurovascular damage. This method can be safely used at the tumor periphery. Meticulous microsurgical dissection between the pia mater and tumor surface can facilitate en bloc tumor removal.[13]

When attempting a complete resection, wide resection of the dural attachment tends to reduce the rate of recurrence; however, dural coagulation can also be performed.[14] Splitting the dura mater into inner and outer layers is a simple technique that does not require complicated duraplasty with fascia or artificial dura.[15] The use of intraoperative neuromonitoring techniques to assess motor evoked potentials (MEPs) and somatosensory evoked potentials (SSEPs) helps in reducing postoperative iatrogenic neurologic deficits.[16]

Approximately 90% of spinal meningiomas can be surgically resected with Simpson's grade-1 resection. The rate of recurrence during long-term follow-up reportedly ranges from 4 to 10%.[10]

Adjunctive radiation therapy is considered for cases requiring subtotal resection; those with recurrent meningiomas, anterior tumor location, and en plaque and calcified meningiomas; and those wherein the surgical risk is extremely high, given patients' comorbidities and tumor location.[17] [18]


 

Conclusion and Recommendations

Spinal meningiomas with a hypointense signal on MRI should indicate surgeons about the possibility of calcified or ossified meningiomas. The authors recommend the use of preoperative CT to detect sites of ossification. Intraoperative neuromonitoring of MEPs and SSEPs, use of a wide surgical corridor with total laminectomy, wide dural opening, identification of upper and lower poles, and early CSF drainage are helpful in decreasing neural retraction, thereby facilitating safe total resection. The authors recommend dural resection or coagulation to reduce the rate of recurrence and to avoid redo surgeries.


 

 

Conflict of Interest

None declared.


Address for correspondence

Ahmed Alawamry, MD
Department of Neurosurgery, Faculty of Medicine
Zagazig University, Zagazig 44511
Egypt   


  Permissions and Reprints
Zoom
Fig. 1 (A) T1-weighted dorsal spine magnetic resonance imaging (MRI) showing spinal meningioma opposite T4–T5 with hypointense signals denoting calcifications. (B) T2-weighted dorsal spine MRI showing spinal meningioma opposite T4–T5 with hypointense signals denoting calcifications.
Zoom
Fig. 2 Intraoperative image of excised ossified meningioma.
Zoom
Fig. 3 Postoperative T2-weighted MRI showing complete tumor removal. MRI, magnetic resonance imaging.
Zoom
Fig. 4 (A) Photomicrograph showing meningothelial cells, calcified psammoma bodies, and scattered foci of ossification (hematoxylin and eosin [H&E], ×40). (B) Photomicrograph showing areas of irregular, calcified bone trabeculae (star) and calcified psammoma body (arrow; H&E, ×400).