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J Pediatr Genet 2019; 08(04): 240-243
DOI: 10.1055/s-0039-1692414
Case Report
Georg Thieme Verlag KG Stuttgart · New York

A Newborn with Severe Ventriculomegaly: Expanding the PPP2R1A Gene Mutation Phenotype

Alexandra Wallace 
1   Department of Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts, United States
,
Paul Caruso
2   Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States
,
Amel Karaa
3   Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States
› Author Affiliations
Further Information

Publication History

24 March 2019

03 May 2019

Publication Date:
12 June 2019 (online)

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Abstract

Protein phosphatase 2A (PP2A) is a heterotrimeric protein serine/threonine phosphatase that regulates a diverse range of cellular activities. The PPP2R1A gene on chromosome 19 (19q13.41) encodes the α isoform of the scaffolding subunit of the PP2A holoenzyme, which functions to link the catalytic subunit to the regulatory subunit. Here we present a case of a newborn boy with a novel PPP2R1A gene mutation (c.548G>A; p.Arg183Gln) with severe lateral and third ventriculomegaly, hypoplastic corpus callosum, and pontocerebellar hypoplasia. To our knowledge, this is the sixth case reported in the literature, thus expanding the phenotype of this rare genetic condition.

Keywords

protein phosphatase 2A - PPP2R1A - ventriculomegaly
 

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