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DOI: 10.1055/s-0039-1689473
Effect of Ethyloestrenol on Fibrinolysis in the Vessel Wall
Publication History
Publication Date:
22 May 2019 (online)
It has been shown that phenformin plus ethyloestrenol causes a significant increase in the fibrinolytic activity of the vessel wall in most patients with recurrent idiopathic venous thrombosis and with an initially low fibrinolytic activity in the vein walls. At the same time a marked decrease in the frequency of thrombotic episodes occurred (Nilsson et al. 1974). Due to side effects of phenformin attempts have been made to administrate ethyloestrenol alone to patients with an abnormally low plasminogen activator content of the vessel wall and/or a decreased capacity to release plasminogen activator from the vein walls on venous occlusion of the arms. Ethyloestrenol in a dose of 8 mg/d has been given to 34 patients for 3 to 6 months and to 6 patients for 12 months. Ethyloestrenol caused a significant increase in the fibrinolytic activity in 30 of the 34 patients treated for 3-6 months and in 5 of those 6 treated for 12 months. Ethyloestrenol in a dose of 4 mg/d had no effect.