Thromb Haemost 1976; 36(01): 273-276
DOI: 10.1055/s-0039-1688744
International Committee Communication
Schattauer GmbH

D. Platelet Factor 4 (PF4) - Platelet Protein with Heparin Neutralizing Activity[*]

S. Niewiarowski
1   From the Specialized Center for Thrombosis Research, Temple University Health Sciences Center, Philadelphia, Pa., U.S.A.
› Author Affiliations
Further Information

Publication History

Publication Date:
23 April 2019 (online)

 

* This topic was discussed by Drs. Gjesdahl, Hawiger, Ludlam, Lüscher, Niewiarowski, and O’Brien.


 
  • References: Section D

  • 1 Barber A. G., Käser-Glanzmann R., Jakabova M., Lüscher E. F.. 1972; Characterization of chondroitin sulfate proteoglycan carrier for heparin neutralizing activity - (PF4) released from human blood platelets. Biochimica et Biophysica Acta 286: 312.
  • 2 Bolton A. E., Ludlam C. A., Pepper D. S., Moore S., Cash J. D.. 1976; A radioimmunoassay for platelet factor 4. Thrombosis Research 8: 51.
  • 3 daPrada M., Jakabova R., Lüscher E. F., Pletscher A., Richards J. G.. 1976; Subcellular localization of the heparin neutralizing factor in blood platelets. Journal of Physiology 257: 495.
  • 4 Gjesdahl K.. 1974; Platelet factor 4 (PF4): An electroimmunoassay for PF4 in human plasma. Scandinavian Journal of Haematology 13: 232.
  • 5 Handin R. I., Cohen H. J.. 1976 Purification and binding properties of human platelet factor 4. Journal of Biological Chemistry. in press
  • 6 Harada K., Zucker M. B.. 1971; Simultaneous development of platelet factor 4 activity and release of 14C-serotonin. Thrombosis et Diathesis Haemorrhagica 25: 41.
  • 7 Hawiger J., Niewiarowski S.. 1975; Antiheparin factor of human platelets (platelet factor 4, PF4): Immunological detection in plasma, serum and during endotoxin induced release reaction in vitro. Blood 46: 1020 (abstract)
  • 8 Joist J. H., Niewiarowski S., Nath N., Mustard J. F.. 1976; Platelet antiplasmin: Its extrusion during the release reaction, subcellular localization, characterization and relationship to antiheparin in pig platelets. Journal of Laboratory and Clinical Medicine 87: 659.
  • 9 Käser-Glanzmann R., Jakabova M., Lüscher E. F.. 1972; Isolation and some properties of the heparin neutralizing factor (PF4) released from human blood platelets. Experientia 28: 1221.
  • 10 Käser-Glanzmann R., Jakabova M., Lüscher E. F.. 1972-73 Heparin-neutralizing factor (platelet factor 4) from human blood platelets and its reactivity with fibrinogen and soluble fibrinmonomer complexes. Hemostasis 1: 136.
  • 11 Levine S. P., Wohl H.. 1976; Human platelet factor 4 (PF4). Purification and characterization by affinity chromatography. Journal of Biological Chemistry 251: 324.
  • 12 Ludlam C. A., Moore S., Bolton A. E., Pepper D. S., Cash J. D.. 1975; The release of a human platelet specific protein measured by a radioimmunoassay. Thrombosis Research 6: 543.
  • 13 Moore S., Pepper D., Cash J.. 1975; Platelet antiheparin activity: The isolation and characterization of platelet factor 4 released from thrombin-aggregated washed human platelets and its dissociation into subunits and the isolation of membrane-bound antiheparin activity. Biochimica et Biophysica Acta 379: 370.
  • 14 Nath N., Lowery C. T., Niewiarowski S.. 1975; Antigenic and antiheparin properties of human platelet factor 4 (PF4). Blood 45: 537.
  • 15 Nath N., Niewiarowski S., Joist J.. 1973; Platelet factor 4 - antiheparin protein releasable from platelets, purification and properties. Journal of Laboratory and Clinical Medicine 82: 754.
  • 16 Nath, N., Salganicoff, L., Fukami, M. and Niewiarowski, S.: unpublished observations.
  • 17 Niewiarowski S., Lowery C. T., Hawiger J., Millman M., Timmons S.. 1976; Immunoassay of human platelet factor 4 (PF4, antiheparin factor) by radial immuno-diffusion. Journal of Laboratory and Clinical Medicine 87: 120.
  • 18 Niewiarowski S., Lukasiewicz H., Nath N.. 1974; Platelet aggregation and release triggered by antibody to platelet factor 4 (PF4). Proceedings of the Society for Experimental Biology and Medicine 147: 188.
  • 19 Niewiarowski S., Poplawski A., Lipinski B., Farbiszewski R.. 1968; The release of platelet clotting factors during aggregation and viscous metamorphosis. Experimental Biology and Medicine 3: 121.
  • 20 Niewiarowski S., Thomas D. P.. 1969; Platelet factor 4 and adenosine diphosphate release during human platelet aggregation. Nature 222: 1269.
  • 21 O’Brien J. R., Etherington M., Jamieson S., Lawford P., Sussex J., Ijncoln S. V.. 1975; Heparin neutralizing activity - test in the diagnosis of acute myocardial infarction. Journal of Clinical Pathology 28: 975.
  • 22 O’Brien J. R., Finch W., Clark E.. 1970; Platelet bound and soluble platelet factor 4: Effect of aggregating agents, of aggregation and of aspirin. Proceedings of the Society for Experimental Biology and Medicine 134: 1128.
  • 23 Walsh P. N., Gagnatelli G.. 1974; Platelet antiheparin activity: Storage site and release mechanism. Blood 44: 157.
  • 24 Youssef A. H., Barkhan P.. 1969; Inhibition by aspirin of release of antiheparin activity from human platelets. British Medical Journal 3: 394.
  • 25 Zucker M. B., Grant R. A.. 1974; Aggregation and release reaction induced in human blood platelets by zymosan. Journal of Immunology 112: 1219.