Towards a Simultaneous and Harmonized Regulation of Haemostasis and of the Cardiovascular System

I-Desoxy-l-(5-hydroxytryptamino)-D-fructose is a synthetic sugar derivative of serotonin, however, its spontaneous formation under physiological conditions is quite possible (5th Inter. Congr. Thromb. Haemost., Paris, 1975, Abstr. n°233). This, and similar sugar derivatives of serotonin show a serotonin-like activity, however, a discrepancy has been observed between their affinities towards D and M type tryptaminergic receptors, when compared with the affinity of serotonin for the same receptors. The sugar derivatives have been distinguished by an increased passage of the blood-brain barrier and by a limited uptake by theplatelet. They exhibit a mechanism which mildly inhibits platelet functions, while mildly supporting haemostasis by vascular smooth muscle contraction. Besides the regulation of blood pressure, heart rate and sinusal coronary flow, some typical central effects (anti-stress activity, suppression of the carotid occlusion response, etc.) have also been observed, which have a beneficial effect on the cardiovascular system. Progressing in this way, it is hoped to have a new approach to inhibiting thrombosis without significantly interfering with haemostasis.