Influence of Anticoagulant? Antiaggregant and Antifibrinolytic Drugs on the Walker-256-Carcinosarcoma of Rats

In order to find out, if there ia en influence of blood coagulation factors on tumura we determinad the effects of various anticoagulant drugs (Phenprocoumon, Arvinr , Acet.-salicyl.-acid) and the antifibrinolytics (EACA) on the development, metastasia formation and the ratxa of survival of the walker-256-tumour. Tumorcells were the subcutanously injected upon the back of the tail of female Whistar rats in a total number of 850. We tested the effect of Marcoumar by weekly controls of Quick’s test of every single rat. 52 % of the control survived, while up to 96 % of the rats which were treated with different doses of Marcoumar survived. (n=23 in each group). In another series only 25 % of control-anmals sunaved, but 64 % of the rats, which were treated with EACA and with ASA, and 33 % of the rats which were treated with Arvin, survived (n= 2-7 ,in every group) The spread of the tumour in Arvin-treated rats was most invasible. The effects of clotting mechanism on the four stages in the spreding tumour are being discussed.