Thromb Haemost 1979; 42(01): 452
DOI: 10.1055/s-0039-1687527
Supplementary Abstracts
Schattauer GmbH

Effect of Age and Site on Transfusion Requirements of Adolescents With Severe Haemophilia A.

A. Aronstam
1   Treloar Haemophilia Centre, Lord Mayor TreLoar Hospital, Alton, Hampshire.
,
D.S. McLellan
1   Treloar Haemophilia Centre, Lord Mayor TreLoar Hospital, Alton, Hampshire.
,
P. Turk
1   Treloar Haemophilia Centre, Lord Mayor TreLoar Hospital, Alton, Hampshire.
› Author Affiliations
Further Information

Publication History

Publication Date:
26 April 2019 (online)

 

    4935 bleeding episodes in 75 adolescents with severe haemophilia A and without inhibitors to Factor VIII were studied during 5 years 1973-1977 6726 Factor VIII transfusions were given. 1.22 transfusions per bleed given in 1973 rose to 1.39 transfusions per bleed in 1977. 1.20 transfusions per bleed were given to 10 year olds which rose to 1.47 at 15 years. 745 bleeding episodes needed retransfusion within 24 hours. Iliopsoas (61% of bleeds) and retroperitoneal (58% of bleeds) were the sites needing most retransfusions wichin 24 hours. Total transfusions per bleed were most frequent in retroperitoneal (3.6) and iliopsoas (2.5) bleeds. On 181 occasions bleeds occurred into more than one site simultaneously and required 221 transfusions for complete resolution. Multiple bleeds involving the thigh (1.4) and upper arm (1.4) required most transfusions per bleeding episode.

    Conclusions are that adolescent transfusion requirements peak at 15 years. Bleeds into the psoas and retroperitoneum may benefit from higher initial doses of Factor VIII and multiple bleeds require no more initial therapy than single bleeds.


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