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Thromb Haemost 1979; 42(01): 440
DOI: 10.1055/s-0039-1687492
Supplementary Abstracts
Schattauer GmbH

On the Effects of a Hemostasis Activating Factor (HaF) from Subcutaneous Tissue on Platelet Retention

Authors

  • A. Sayegh

    1   Dept. of Internal Medicine, Div. of Angiology, University, Frankfurt/M.F.R.G.

  • C.M. Kirchmaier

    1   Dept. of Internal Medicine, Div. of Angiology, University, Frankfurt/M.F.R.G.

  • St. Lenhard

    1   Dept. of Internal Medicine, Div. of Angiology, University, Frankfurt/M.F.R.G.

  • M. Wintrich

    1   Dept. of Internal Medicine, Div. of Angiology, University, Frankfurt/M.F.R.G.

  • N. Bender

    1   Dept. of Internal Medicine, Div. of Angiology, University, Frankfurt/M.F.R.G.

  • K. Breddin

    1   Dept. of Internal Medicine, Div. of Angiology, University, Frankfurt/M.F.R.G.
Further Information

Publication History

Publication Date:
26 April 2019 (online)

 
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Extracts of human subcutaneous tissue with a very low thromboplastic activity strongly stimulate platelets (sphering and pseudopode formation) within seconds if added to blood directly at blood sampling (30 μ/ml citrate blood). To study the effect of this hemostasis activating factor (HaF) on platelet retention a special glass bead column with basically low retention (0-15 % in healthy individuals) was prepared. If HaF 50μl/ml) was added to freshly drawn citrate blood retention was increased from a mean of 12 % to a mean of 57 %. Even higher retention rates were obtained by adding a cryoprecipitate from normal PPP (50μl/ml) together with HaF. 100μl/ml of cryoprecipitate markedly enhanced platelet retention. FeibaR (Immuno) alone did not increase platelet retention. Together with HaF FeibaR (50μl/ml citrate blood) induced a 85% retention. The enhancing effect of HaF on platelet retention is probably caused by rapid platelet stimulation and may be an essential trigger mechanism for primary hemostasis.


 


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