In Vivo Detection of Platelet Deposition in Coronary Artery Bypass Grafts in Dogs and Its Prevention with Platelet-Inhibitors

At 8 and 32 hours after saphenous vein bypass graft surgery in 7 dogs, in vivo images of the graft were obtained with a gamma camera after I.V. injection, 2 hours postoperatively of autologous ¹¹¹In-Iabelled platelets. Platelet deposition in the grafts could be imaged from the scintiphotos. Under identical conditions, in 9 dogs treated with Dipyridamole (2.5 mgs/kg/day) plus Aspirin (15 mgs/kg/day) (D + ASA), the grafts had significantly less platelet deposition as estimated by imaging (P <0.01). The in vitro radioactivity ratios (mean ± S.E.) of isolated graft sections to nontarget tissues of control and treated animals are as follows:

This noninvasive technique may be a promising tool for a better understanding of the role played by platelets in the process of occlusion of saphenous vein bypass grafts in man and its prevention with platelet inhibitors.

 

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