Additional sublingual Immunotherapy to Anti-IGE Therapy for nasal polyps

Introduction:

To identify better therapy for chronic sinusitis with polyps.

Methods:

We had 10 patients in this study with allergic rhinitis according to skin prick test (sensitized to mites) and nasal polyps.

The patients underwent endoscopy with photodocumentation who had a mild improvement after therapy with oral antihistaminic and nasal spray. They also had poor respond to oral corticoid therapy. The patient's age was ranging from 29 to 47 years old. 5 of them started anti-IgE therapy (omalizumab) only. The rest in additional to anti-IgE therapy started also sublingual immunotherapy for mites.

The patients were examined 2 months, 9 months and 1 year later and were asked for their symptoms and the need of use of the former therapy (oral antihistaminic and nasal corticoid spray). It was again an endoscopic photodocimentation performed.

Results:

3 months later there was a better symptomatic improvement to the second group, with most reduced polyp size and better control of the disease.

9 months later after the initial therapy there was no more further change to our results. 1 year later there was 1 patient from the 1st group with no further improvement. All the patients from the second group were even better according to their symptoms and the size of their polyps.

Conclusion:

we should consider to treat our patients with CRSwNP with anti-IgE therapy together with sublingual therapy

Dr. med Anna Yakinthou

Praxis,

P.Mela 37, 54622

Thessaloniki, Griechenland

Email: [e-mail]

Publication History

Publication Date:
23 April 2019 (online)