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Thromb Haemost 1979; 42(01): 247
DOI: 10.1055/s-0039-1684776
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Prostaglandins and Thromboxanes in Platelet Aggregation
Schattauer GmbH

Effect of PGI2 and Its Derivatives on Platelet Adherence Aggregation and PF3 Availability

Authors

  • L. Fésüs

    x   Chinoin Pharmaceutical and Chemical Works Ltd., Budapest, Hungary

  • I. Stadler

    x   Chinoin Pharmaceutical and Chemical Works Ltd., Budapest, Hungary

  • J. Hársfalvi

    1   Department of Clinical Chemistry, Univ. Sch. Med., Debrecen

  • M. Balogh

    1   Department of Clinical Chemistry, Univ. Sch. Med., Debrecen

  • E. Kovács

    1   Department of Clinical Chemistry, Univ. Sch. Med., Debrecen

  • L. Muszbek

    1   Department of Clinical Chemistry, Univ. Sch. Med., Debrecen
Further Information

Publication History

Publication Date:
18 April 2019 (online)

 
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10-8M PGI2-Na completely inhibited collagen induced aggregation of human platelets and the concomitant appearance of platelet factor 3 activity, but did not affect the adherence of platelets to collagen fibrils. At the same time, the presence of PGI2-Na could prevent the retention of platelets by glass beads.

Comparing to the inhibition of ADP induced aggregation a higher dose of PGI2-Na was needed to inhibit platelet aggregation by ionophore A23187. Furthermore, unlike ADP aggregation, increasing dose of ionophore could counteract the inhibitory effect of PGI2-Na. The shift of platelet actin from G to F from during ionophore aggregation could be prevented by appropriate dose of PGI2-Na. PGI2 derivatives (Chinoin, Hungary) with increased stability, although in higher doses, exerted activities similar to PGI2-Na.


 


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