Thromb Haemost 1979; 42(01): 100
DOI: 10.1055/s-0039-1684504
Clinical and Pharmacological Action of Sulphinpyrazone
Schattauer GmbH

Effects of Aspirin and Sulfinpyrazone on Thromboxane and Prostacyclin Synthesis in Rabbits

J.W.D. McDonald
1   Department of Medicine, University of Western Ontario, London, Ontario, Canada
,
A.L. Cerskus
1   Department of Medicine, University of Western Ontario, London, Ontario, Canada
,
M. Ali
1   Department of Medicine, University of Western Ontario, London, Ontario, Canada
› Author Affiliations
Further Information

Publication History

Publication Date:
26 April 2019 (online)

 

    Arachidonic acid (AA) or collagen were infused into rabbits causing intravascular platelet aggregation with thrombocytopenia, hypotension and death. Thromboxane and prostacyclin synthesis were measured by radioimmunoassay of plasma TXB2 and 6-keto-PCF1α. The effects of pretreatment with aspirin (ASA) or sulfinpyrazone (SPZ) were assessed.

    Death in drug-treated rabbits was always associated with elevations of plasma TXB2 (1-40 ng/ml) and of 6-keto-PGF1α (1-20 ng/ml). Collagen produced only small elevations of plasma TXB2 compared to AA but protection by ASA correlated better with inhibition of TXB2 and 6-keto-PGF1α synthesis than with inhibition of aggregation. Low dose ASA produced less inhibition of prostacyclin synthesis than high dose ASA but was less effective in preventing thromboxane synthesis and death.


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