Nuklearmedizin 2019; 58(02): 188
DOI: 10.1055/s-0039-1683722
Poster
PET: Onkologie - FDG
Georg Thieme Verlag KG Stuttgart · New York

Evaluation of diagnostic value of TOF-F-18-FDG PET/CT in patients with suspected pancreatic cancer

S Stanzel
1   Med. Universität Graz, Nuklearmedizin, Graz
,
F Quehenberger
2   Med. Universität Graz, Institut für Med. Informatik, Statistik und Dokumentation, Graz
,
F Weitzer
1   Med. Universität Graz, Nuklearmedizin, Graz
,
S Kerschbaumer
1   Med. Universität Graz, Nuklearmedizin, Graz
,
RM Aigner
1   Med. Universität Graz, Nuklearmedizin, Graz
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2019 (online)

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    Ziel/Aim:

    Evaluation of the advantages of time-of-flight (TOF) in F-18-FDG-PET/CT in the detection and characterization of pancreatic lesions in patients with suspected pancreatic cancer.

    Methodik/Methods:

    TOF-F-18-FDG-PET/CT was prospectively performed in 91 patients with suspected pancreatic cancer. In all patients, a histopathologic confirmation was made. PET/CT imaging was performed 30 and 90 Min. p.i. including a diagnostic CT of the upper abdomen. The SUVmax of the lesions was measured and compared in the PET images with and without TOF 30 and 90 min. p.i. The determination of diagnostic usefulness of TOF-PET/CT in comparison with standard PET/CT images was made using ROC-analysis.

    Ergebnisse/Results:

    Of 91 patients 64 patients had malignant and 27 patients a benign pancreatic lesion. Mean lesion size was 3.07 cm ± 1.77. With TOF-PET/CT significant more with diagnostic CT detected pancreatic lesions could be identified than without TOF (87 vs.74; p < 0.0001). Thus, 13 lesions showed an increased tracer uptake with TOF alone, whereby 1 adenocarcinoma, 2 IPMN and 1 serous microcystic adenoma in 4 patients (4%) were diagnosed correctly regarding dignity only with TOF. Based on the histopathologic findings sensitivity, specificity and diagnostic accuracy for TOF were 92%, 67% and 85% versus 86%, 74% and 82% without TOF. ROC-analysis of SUVmax with TOF 30 and 90 min. p.i. yielded a cut-off value of 5 and 6.6, respectively with a sensitivity and specificity of 81% and 79% and 78% and 81%. The area under the curve AUCPET and AUCTOF-values showed no significant difference neither in the early nor the delayed images (p = 0.42 in each case).

    Schlussfolgerungen/Conclusions:

    Among patients with suspected pancreatic cancer, the use of TOF-PET/CT correlated with higher sensitivity due to a better anatomical localization and identification of pancreatic lesions. This led to advantages characterizing pancreatic lesions in 4% of patients. However, generally, TOF-PET/CT is of no additional use in differentiating malignant and benign pancreatic lesions.


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