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Thromb Haemost 1977; 38(01): 370
DOI: 10.1055/s-0039-1682565
Poster Session III
Schattauer GmbH

Recurrent Acute Hepatitis Following the Use of Antihemophilic Factor Concentrates

Authors

  • C.L. Tembrevilla-Zubiri

    1   Veterans Administration Hospital, Newington, Connecticut, University of Connecticut School of Medicine, Farmington, Connecticut, and the Hartford Hospital, Hartford, Connecticut, U.S.A.

  • F.R. Rickles

    1   Veterans Administration Hospital, Newington, Connecticut, University of Connecticut School of Medicine, Farmington, Connecticut, and the Hartford Hospital, Hartford, Connecticut, U.S.A.

  • A.U. Klatsky

    1   Veterans Administration Hospital, Newington, Connecticut, University of Connecticut School of Medicine, Farmington, Connecticut, and the Hartford Hospital, Hartford, Connecticut, U.S.A.
Further Information

Publication History

Publication Date:
16 April 2019 (online)

 
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    A patient with Hemophilia A experienced 5 well-documented episodes of acute icteric hepatitis within five to ten days following 5 separate infusions of concentrates of antihemophilic factor over a 3 year period. We were unable to demonstrate either consistent in vitro lymphocyte transformation or in vivo antibody formation in response to a variety of concentrates of antihemophilic factor. Nevertheless, although the mechanism remains unclear, it is likely that these episodes represented an immune response of the patient’s hepatocytes to protein (s) contained in the antihemophilic concentrates. Further studies to define the exact mechanism of hepatocellular injury in this case are in progress. Meanwhile, this communication is, to our knowledge, the first reported case of probable “immune complex” hepatitis as a regular complication of replacement therapy in hemophilia. This unusual complication must be considered in the differential diagnosis of post-transfusion liver dysfunction.


     

     


     
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