Relations of Serum α₁-Antitrypsin and α₁-Antichymotrypsin to Restoration of Movement Ability in Cerebrovascular Patients

Because fibrinolysis and blood clotting system is closely related to arteriosclerotic disorders, determination of serum α₁-antitrypsin (α₁ - AT), α₁-antichymotrypsin (α₁-ACT) must be reasonable to detect the pathophysiologic status in patients with sequelae of cerebrovascular accidents. α₁-AT and ai-ACT were determined by means of single radial immunodiffusion method. The level of α₁-ACT was demonstrated by area of precipitating ring formed on the agar plate. The mean values and standard deviations of α₁-AT was 272158.1 mg/dl in 86 patients admitted in rehabilitation hospital, 312134.9 mg/dl in 32 patients residing in the geriatric nursing home and 229148.0 mg/dl in 135 healthy adults, being significantly higher in patients than healthy, and in nursing patients than in hospitalized patients, α₁-AT level was significantly higher in the patients aged over 40 than in those under 39, higher in the patients poor marks in the test of activities of daily livings (ADL-T) than in those with good marks, higher in those.with impaired renal functions than in those with normal functions. α₁-ACT level was 52110.0 mm² in 86 hospitalized patient, 70115.1 mm² in 32 nursing patients and 48±6.3 mg/dl in 135 healthy adults, being significantly higher in patients than in healthy, and in nursing patients than in hospitalized patients. These results suggest that the fibrinolytic factor and proteinase inhibitor are closely associated with restoration of patient’s movement ability. It is concluded that the study of this system contributes not only to the etiologic research but also to the progress of the rehabilitation medicine in the cerebrovascular diseases.

 

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