J Neurol Surg B Skull Base 2019; 80(02): 156-164
DOI: 10.1055/s-0039-1677680
Invited Review
Georg Thieme Verlag KG Stuttgart · New York

Hearing Preservation in Stereotactic Radiosurgery for Vestibular Schwannoma

Anthony M. Tolisano
1   Department of Otolaryngology, University of Texas Southwestern Medical Center, Dallas, Texas, United States
,
Jacob B. Hunter
1   Department of Otolaryngology, University of Texas Southwestern Medical Center, Dallas, Texas, United States
› Author Affiliations
Further Information

Publication History

25 April 2018

05 December 2018

Publication Date:
10 January 2019 (online)

Abstract

Despite no universally accepted definition of hearing preservation following vestibular schwannoma (VS) treatment, numerous variables have been identified as possible factors that may affect hearing outcomes following radiotherapy. Age, pretreatment hearing, radiation dose, tumor location and size, length of follow-up, fractionation, and timing of radiation have all been explored, among other variables, as factors related to hearing outcomes following radiation. These variables and associated hearing outcomes will be explored in detail, summarizing the literature to date to improve patient counseling for those patients who present with serviceable hearing and are considering their VS management options.

 
  • References

  • 1 Brackmann DE, Bartels LJ. Rare tumors of the cerebellopontine angle. Otolaryngol Head Neck Surg (1979) 1980; 88 (05) 555-559
  • 2 Kasantikul V, Netsky MG, Glasscock III ME, Hays JW. Acoustic neurilemmoma. Clinicoanatomical study of 103 patients. J Neurosurg 1980; 52 (01) 28-35
  • 3 Stangerup SE, Caye-Thomasen P. Epidemiology and natural history of vestibular schwannomas. Otolaryngol Clin North Am 2012; 45 (02) 257-268 , vii
  • 4 Committee on Hearing and Equilibrium guidelines for the evaluation of hearing preservation in acoustic neuroma (vestibular schwannoma). American Academy of Otolaryngology-Head and Neck Surgery Foundation, INC. Otolaryngol Head Neck Surg 1995; 113 (03) 179-180
  • 5 Gardner G, Robertson JH. Hearing preservation in unilateral acoustic neuroma surgery. Ann Otol Rhinol Laryngol 1988; 97 (01) 55-66
  • 6 Jereczek-Fossa BA, Zarowski A, Milani F, Orecchia R. Radiotherapy-induced ear toxicity. Cancer Treat Rev 2003; 29 (05) 417-430
  • 7 Jacob JT, Carlson ML, Schiefer TK, Pollock BE, Driscoll CL, Link MJ. Significance of cochlear dose in the radiosurgical treatment of vestibular schwannoma: controversies and unanswered questions. Neurosurgery 2014; 74 (05) 466-474 , discussion 474
  • 8 Kano H, Kondziolka D, Khan A, Flickinger JC, Lunsford LD. Predictors of hearing preservation after stereotactic radiosurgery for acoustic neuroma. J Neurosurg 2009; 111 (04) 863-873
  • 9 Strauss C, Fahlbusch R, Romstöck J. , et al. Delayed hearing loss after surgery for acoustic neurinomas: clinical and electrophysiological observations. Neurosurgery 1991; 28 (04) 559-565
  • 10 Tamura M, Carron R, Yomo S. , et al. Hearing preservation after gamma knife radiosurgery for vestibular schwannomas presenting with high-level hearing. Neurosurgery 2009; 64 (02) 289-296 , discussion 296
  • 11 Delbrouck C, Hassid S, Massager N. , et al. Preservation of hearing in vestibular schwannomas treated by radiosurgery using Leksell Gamma Knife: preliminary report of a prospective Belgian clinical study. Acta Otorhinolaryngol Belg 2003; 57 (03) 197-204
  • 12 van Eck AT, Horstmann GA. Increased preservation of functional hearing after gamma knife surgery for vestibular schwannoma. J Neurosurg 2005; 102 (Suppl): 204-206
  • 13 Asthagiri AR, Vasquez RA, Butman JA. , et al. Mechanisms of hearing loss in neurofibromatosis type 2. PLoS One 2012; 7 (09) e46132
  • 14 van de Langenberg R, de Bondt BJ, Nelemans PJ, Dohmen AJ, Baumert BG, Stokroos RJ. Predictors of volumetric growth and auditory deterioration in vestibular schwannomas followed in a wait and scan policy. Otol Neurotol 2011; 32 (02) 338-344
  • 15 Miller ME, Mafee MF, Bykowski J. , et al. Hearing preservation and vestibular schwannoma: intracochlear FLAIR signal relates to hearing level. Otol Neurotol 2014; 35 (02) 348-352
  • 16 Bhandare N, Antonelli PJ, Morris CG, Malayapa RS, Mendenhall WM. Ototoxicity after radiotherapy for head and neck tumors. Int J Radiat Oncol Biol Phys 2007; 67 (02) 469-479
  • 17 Pan CC, Eisbruch A, Lee JS, Snorrason RM, Ten Haken RK, Kileny PR. Prospective study of inner ear radiation dose and hearing loss in head-and-neck cancer patients. Int J Radiat Oncol Biol Phys 2005; 61 (05) 1393-1402
  • 18 Kwong DL, Wei WI, Sham JS. , et al. Sensorineural hearing loss in patients treated for nasopharyngeal carcinoma: a prospective study of the effect of radiation and cisplatin treatment. Int J Radiat Oncol Biol Phys 1996; 36 (02) 281-289
  • 19 Ho WK, Wei WI, Kwong DL. , et al. Long-term sensorineural hearing deficit following radiotherapy in patients suffering from nasopharyngeal carcinoma: a prospective study. Head Neck 1999; 21 (06) 547-553
  • 20 Honoré HB, Bentzen SM, Møller K, Grau C. Sensori-neural hearing loss after radiotherapy for nasopharyngeal carcinoma: individualized risk estimation. Radiother Oncol 2002; 65 (01) 9-16
  • 21 Lin RH, Wang TC, Lin CD. , et al. Predictors of hearing outcomes following low-dose stereotactic radiosurgery in patients with vestibular schwannomas: a retrospective cohort review. Clin Neurol Neurosurg 2017; 162: 16-21
  • 22 Yang I, Sughrue ME, Han SJ. , et al. A comprehensive analysis of hearing preservation after radiosurgery for vestibular schwannoma: clinical article. J Neurosurg 2013; 119 (Suppl): 851-859
  • 23 Mousavi SH, Niranjan A, Akpinar B. , et al. Hearing subclassification may predict long-term auditory outcomes after radiosurgery for vestibular schwannoma patients with good hearing. J Neurosurg 2016; 125 (04) 845-852
  • 24 Hasegawa T, Kida Y, Kato T, Iizuka H, Yamamoto T. Factors associated with hearing preservation after Gamma Knife surgery for vestibular schwannomas in patients who retain serviceable hearing. J Neurosurg 2011; 115 (06) 1078-1086
  • 25 Horiba A, Hayashi M, Chernov M, Kawamata T, Okada Y. Hearing preservation after low-dose gamma knife radiosurgery of vestibular schwannomas. Neurol Med Chir (Tokyo) 2016; 56 (04) 186-192
  • 26 Linskey ME, Johnstone PA, O'Leary M, Goetsch S. Radiation exposure of normal temporal bone structures during stereotactically guided gamma knife surgery for vestibular schwannomas. J Neurosurg 2003; 98 (04) 800-806
  • 27 Linskey ME. Hearing preservation in vestibular schwannoma stereotactic radiosurgery: what really matters?. J Neurosurg 2008; 109 (Suppl): 129-136
  • 28 Massager N, Nissim O, Delbrouck C. , et al. Irradiation of cochlear structures during vestibular schwannoma radiosurgery and associated hearing outcome. J Neurosurg 2007; 107 (04) 733-739
  • 29 Foote KD, Friedman WA, Buatti JM, Meeks SL, Bova FJ, Kubilis PS. Analysis of risk factors associated with radiosurgery for vestibular schwannoma. J Neurosurg 2001; 95 (03) 440-449
  • 30 Paek SH, Chung HT, Jeong SS. , et al. Hearing preservation after gamma knife stereotactic radiosurgery of vestibular schwannoma. Cancer 2005; 104 (03) 580-590
  • 31 Yomo S, Carron R, Thomassin JM, Roche PH, Régis J. Longitudinal analysis of hearing before and after radiosurgery for vestibular schwannoma. J Neurosurg 2012; 117 (05) 877-885
  • 32 Gabert K, Régis J, Delsanti C. , et al. Preserving hearing function after Gamma Knife radiosurgery for unilateral vestibular schwannoma [in French]. Neurochirurgie 2004; 50 (2–3, Pt 2): 350-357
  • 33 Pan SY, Liu SA, Sun MH. , et al. Outcome of hearing preservation related to tumor morphologic analysis in acoustic neuromas treated by gamma knife radiosurgery. Radiat Oncol 2017; 12 (01) 134-017
  • 34 Massager N, Nissim O, Delbrouck C. , et al. Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery. Int J Radiat Oncol Biol Phys 2006; 64 (05) 1331-1340
  • 35 Ohata K, Tsuyuguchi N, Morino M. , et al. A hypothesis of epiarachnoidal growth of vestibular schwannoma at the cerebello-pontine angle: surgical importance. J Postgrad Med 2002; 48 (04) 253-258 , discussion 258–259
  • 36 Park MJ, Park HJ, Chung JW. , et al. Factors affecting hearing deterioration in vestibular schwannoma patients treated with gamma knife radiosurgery: the Asan Medical Center experience. Acta Otolaryngol 2018; 138 (02) 96-104
  • 37 Carlson ML, Vivas EX, McCracken DJ. , et al. Congress of neurological surgeons systematic review and evidence-based guidelines on hearing preservation outcomes in patients with sporadic vestibular schwannomas. Neurosurgery 2018; 82 (02) E35-E39
  • 38 Hasegawa T, Kato T, Kida Y. , et al. Gamma Knife surgery for patients with facial nerve schwannomas: a multiinstitutional retrospective study in Japan. J Neurosurg 2016; 124 (02) 403-410
  • 39 Pollock BE, Link MJ, Foote RL, Stafford SL, Brown PD, Schomberg PJ. Radiosurgery as primary management for meningiomas extending into the internal auditory canal. Stereotact Funct Neurosurg 2004; 82 (2–3): 98-103
  • 40 Carlson ML, Jacob JT, Pollock BE. , et al. Long-term hearing outcomes following stereotactic radiosurgery for vestibular schwannoma: patterns of hearing loss and variables influencing audiometric decline. J Neurosurg 2013; 118 (03) 579-587
  • 41 Coughlin AR, Willman TJ, Gubbels SP. Systematic review of hearing preservation after radiotherapy for vestibular schwannoma. Otol Neurotol 2018; 39 (03) 273-283
  • 42 Andrews DW, Suarez O, Goldman HW. , et al. Stereotactic radiosurgery and fractionated stereotactic radiotherapy for the treatment of acoustic schwannomas: comparative observations of 125 patients treated at one institution. Int J Radiat Oncol Biol Phys 2001; 50 (05) 1265-1278
  • 43 Bennion NR, Nowak RK, Lyden ER, Thompson RB, Li S, Lin C. Fractionated stereotactic radiation therapy for vestibular schwannomas: dosimetric factors predictive of hearing outcomes. Pract Radiat Oncol 2016; 6 (05) e155-e162
  • 44 Combs SE, Welzel T, Schulz-Ertner D, Huber PE, Debus J. Differences in clinical results after LINAC-based single-dose radiosurgery versus fractionated stereotactic radiotherapy for patients with vestibular schwannomas. Int J Radiat Oncol Biol Phys 2010; 76 (01) 193-200
  • 45 Fong BM, Pezeshkian P, Nagasawa DT, De Salles A, Gopen Q, Yang I. Hearing preservation after LINAC radiosurgery and LINAC radiotherapy for vestibular schwannoma. J Clin Neurosci 2012; 19 (08) 1065-1070
  • 46 Kessel KA, Fischer H, Vogel MM. , et al. Fractionated vs. single-fraction stereotactic radiotherapy in patients with vestibular schwannoma: hearing preservation and patients' self-reported outcome based on an established questionnaire. Strahlenther Onkol 2017; 193 (03) 192-199
  • 47 Lo A, Ayre G, Ma R. , et al. Population-based study of stereotactic radiosurgery or fractionated stereotactic radiation therapy for vestibular schwannoma: long-term outcomes and toxicities. Int J Radiat Oncol Biol Phys 2018; 100 (02) 443-451
  • 48 Teo M, Zhang M, Li A. , et al. The outcome of hypofractionated stereotactic radiosurgery for large vestibular schwannomas. World Neurosurg 2016; 93: 398-409
  • 49 Hansasuta A, Choi CY, Gibbs IC. , et al. Multisession stereotactic radiosurgery for vestibular schwannomas: single-institution experience with 383 cases. Neurosurgery 2011; 69 (06) 1200-1209
  • 50 Akpinar B, Mousavi SH, McDowell MM. , et al. Early radiosurgery improves hearing preservation in vestibular schwannoma patients with normal hearing at the time of diagnosis. Int J Radiat Oncol Biol Phys 2016; 95 (02) 729-734
  • 51 Tsai JT, Lin JW, Lin CM. , et al. Clinical evaluation of CyberKnife in the treatment of vestibular schwannomas. BioMed Res Int 2013; 2013: 297093
  • 52 Vivas EX, Wegner R, Conley G. , et al. Treatment outcomes in patients treated with CyberKnife radiosurgery for vestibular schwannoma. Otol Neurotol 2014; 35 (01) 162-170
  • 53 Çakır O, Berkiten G, Tutar B. , et al. Effects of CyberKnife therapy for vestibular schwannoma on hearing: a retrospective study. J Laryngol Otol 2018; 132 (09) 796-801