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Clin Colon Rectal Surg 2018; 31(06): 321-327
DOI: 10.1055/s-0038-1668101
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Vaccinations for Anal Squamous Cancer: Current and Emerging Therapies

John Berry
1   Division of Colon and Rectal Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri
,
Sean C. Glasgow
1   Division of Colon and Rectal Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri
› Author Affiliations
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Publication History

Publication Date:
02 November 2018 (online)

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Abstract

Human papillomavirus (HPV) infection is responsible for 4.3% of the global cancer burden. Since 2006, current HPV vaccines have reduced the prevalence of the virus in adolescent girls, reduced the prevalence of genital warts, and been proven to reduce the progression of anal intraepithelial neoplasia in men. Herein, we review the epidemiology, virology, and immunology behind the prophylactic HPV vaccines and current recommendations for its use. We also review future immune therapies being trialed for use against HPV-related cancers including anal cancer.

Keywords

anal cancer - human papillomavirus - anal intraepithelial neoplasia - anal squamous cell cancer

Disclosures

The view(s) expressed herein are those of the author(s) and do not reflect the official policy or position of the U.S. Army Medical Department, the U.S. Army Office of the Surgeon General, the Department of the Army, Department of Defense, or the U.S. Government.


 

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