Clinical evaluation of rocuronium in patients undergoing neurosurgeries based on body mass index

Methods: This study was done in 111 consecutive patients undergoing neurosurgeries in Fortis hospitals, BG road, Bengaluru. These patients are divided into four groups based on body mass index (BMI), (Group I BMI <20, Group II BMI 20–25, Group III BMI 25–30 and Group IV BMI >30). All patients were induced with injection fentanyl and injection propofol, preservative- free injection xylocard. Patients received injection rocuronium bolus at 0.8 mg/kg for muscle relaxation. Anaesthesia maintained with O₂ + N₂O + sevoflurane + fentanyl. Tetralogy of fallot monitoring was performed throughout the surgery. Onset time for intubation, duration of action of bolus drug was noted. ANOVA test was applied. Post hoc analysis was done using Tukey honestly significant difference test. Results: It is observed that mean value for time for intubation decreased as the BMI increased, and P < 0.05 noted in Group II and Group IV. Similarly, longer duration of action was observed for bolus dose from Group I to Group IV and significance noted in Group III and Group IV (P < 0.05). Conclusion: Patients with higher BMI have shorter time for intubation and longer duration of action for bolus dose of rocuronium.

No conflict of interest has been declared by the author(s).