Dynamic cerebral autoregulation following loading dose of Dexmedetomidine; A transcranial doppler study

Background: Dexmedetomidine has been widely used in neuroanaesthesia and critical care settings. The effects of Dexmedetomidine on cerebral vascular autoregulation and haemodynamic has not been studies in our population. This study is aimed to address this issue. Materials and Methods: Fifteen patients undergoing spinal surgery intracranial pathology were included in this study. Transient hyperemic response testing was done bilaterally with transcranialcolor Doppler. Dynamic autoregulation was assessed with Transient hyperemic response ratio (THRR) and Strength of autoregulation (SA) at baseline and after infusion of Inj. Dexmedetomidine 1 mcg/Kg over 10 minutes. Results: In both hemispheres of the patients without intracranial pathology, significant reduction in THRR and SA values were observed (P < 0.001) after administration of loading dose of Dexmedetomidine. Conclusion: Our study shows that the loading dose of Dexmedetomidine impairs cerebral autoregulation. Caution should be exercised in using this drug in patients with impaired autoregulation.

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[Abstracts published in the Journal of Neuroanaesthesiology and Critical Care have not been reviewed by the Editorial Board of the Journal. These abstracts were presented at the annual meet of ISNACC and selected by the organizers and the scientific committee of the Society]