Intramuscular dexmedetomidine 30 minutes before extubation to assess its effect on post-extubation haemodynamics: A double blind placebo controlled study

Introduction: The effect of intramuscular dexmeditomidine given 30 minutes before extubation on post extubation haemodynamic is studied. Materials and Methods: 50 ASA grade 1 and 2 patients of either sex undergoing elective laminectomy were included in the study. the patients were divided into study group and control group. The study group received dexmeditomidine (2.5 mcg/kg i. m.) in 2.5 ml saline 30 min. before extubation and the control group received normal saline (placebo, i. m.) 2.5 ml. The HR, SBP, MAP, DBP were studied at 1 min., 5 min.,10 min, 15 min.,30 min. post extubation in the study and the control group. Result: The heart rate measured at 1 min., 5 min., 10 min., 15 min., 30 min. post extubation was significantly lower in the study group compared to the control group (P < 0.05) he SBP at 1 min.,15 min., 30 min. post extubation was significantly lower in the study group than in the control group (P < 0.05). The MAP at 1 min., 10 min., 15 min., 30 min. post extubation was significantly lower in the study group than in the control group (P < 0.05). The DBP at 15 min., 30 min. post extubation was significantly lower in the study group than in the control group (P < 0.05). Conclusion: Dexmeditomidine provides greater haemodynamic stability in the post extubation period as compared to the placebo.

No conflict of interest has been declared by the author(s).

[Abstracts published in the Journal of Neuroanaesthesiology and Critical Care have not been reviewed by the Editorial Board of the Journal. These abstracts were presented at the annual meet of ISNACC and selected by the organizers and the scientific committee of the Society]